Understanding how opioids contribute to reward and analgesia

The Integrative Action of the Nervous System.

Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136 · see citing works

Molecular mechanisms of nociception

Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · see citing works

Sensory Mechanisms of the Spinal Cord

Willis, W. D., & Coggeshall, R. E. (1978) · Springer eBooks · doi:10.1007/978-1-4757-1688-7 · Cited by 1,456 · see citing works

THE MECHANISM OF PLACEBO ANALGESIA

Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094 · see citing works

Wall and Melzack's Textbook of Pain

McMahon, S. B., & Koltzenburg, M. (2005) · Cited by 1,014 · see citing works

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

Jessell, T. M., & Iversen, L. L. (1977) · Nature · doi:10.1038/268549a0 · Cited by 970 · see citing works

State-dependent opioid control of pain

Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946 · see citing works

Central nervous system mechanisms of pain modulation

Fields, H. L., Basbaum, A. I., & Heinricher, M. M. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50012-6 · Cited by 757 · see citing works

P AIN M ECHANISMS : Labeled Lines Versus Convergence in Central Processing

Craig, A. D. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131022 · Cited by 749 · see citing works

TREATMENT OF EXCESSIVE AXILLARY SWEATING

Gibbs, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91979-5 · Cited by 560 · see citing works

Opioid modulation of taste hedonics within the ventral striatum

Kelley, A. E., Bakshi, V. P., Haber, S. N., Steininger, T. L., Will, M. J., & Zhang, M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00751-5 · Cited by 526 · see citing works

The Midbrain Periaqueductal Gray as a Coordinator of Action in Response to Fear and Anxiety

Fanselow, M. S. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3302-3_10 · Cited by 405 · see citing works

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Kelley, A. E., Baldo, B. A., & Pratt, W. E. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20769 · Cited by 352 · see citing works

The Midbrain Periaqueductal Gray Matter

Depaulis, A., & Bandler, R. J. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3302-3 · Cited by 317 · see citing works

Psychological Mechanisms of Pain and Analgesia

Price, D. D. (1999) · Cited by 306 · see citing works

The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia

Benedetti, F. (1996) · Pain · doi:10.1016/0304-3959(95)00179-4 · Cited by 296 · see citing works

The role of dopamine in the nucleus accumbens in analgesia

Altier, N., & Stewart, J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00298-2 · Cited by 273 · see citing works

Pain-Induced Analgesia Mediated by Mesolimbic Reward Circuits

Gear, R. W., Aley, K. O., & Levine, J. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07175.1999 · Cited by 269 · see citing works

Conditioned Fear‐Induced Opiate Analgesia: A Competing Motivational State Theory of Stress Analgesia^a

FANSELOW, M. S. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb14617.x · Cited by 238 · see citing works

The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues

Yun, I. A., Wakabayashi, K. T., Fields, H. L., & Nicola, S. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5282-03.2004 · Cited by 238 · see citing works

Acute pain in an emergency clinic: Latency of onset and descriptor patterns related to different injuries

Melzack, R., Wall, P. D., & Ty, T. C. (1982) · Pain · doi:10.1016/0304-3959(82)90078-1 · Cited by 236 · see citing works

Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin

Yoshimura, M., & North, R. A. (1983) · Nature · doi:10.1038/305529a0 · Cited by 231 · see citing works

Encoding of Palatability and Appetitive Behaviors by Distinct Neuronal Populations in the Nucleus Accumbens

Taha, S. A., & Fields, H. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3975-04.2005 · Cited by 217 · see citing works

Central pharmacology of nociceptive transmission

Yaksh, T. L. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50030-8 · Cited by 182 · see citing works

Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord

Glaum, S., Miller, R., & Hammond, D. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04965.1994 · Cited by 152 · see citing works

Pain and the Placebo: What We Have Learned

Hoffman, G. A., Harrington, A., & Fields, H. L. (2005) · Perspectives in biology and medicine · doi:10.1353/pbm.2005.0054 · Cited by 135 · see citing works

Firing of Nucleus Accumbens Neurons During the Consummatory Phase of a Discriminative Stimulus Task Depends on Previous Reward Predictive Cues

Nicola, S. M., Yun, I. A., Wakabayashi, K. T., & Fields, H. L. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00658.2003 · Cited by 131 · see citing works

Targeting Pain-Suppressed Behaviors in Preclinical Assays of Pain and Analgesia: Effects of Morphine on Acetic Acid-Suppressed Feeding in C57BL/6J Mice

Stevenson, G. W., Bilsky, E. J., & Negus, S. S. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.01.447 · Cited by 105 · see citing works

Endorphinergic modulation of neural reward systems indicated by behavioral changes

Dum, J., & Herz, A. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(84)90224-7 · Cited by 97 · see citing works

Conditional hypoalgesia is attenuated by Naltrexone applied to the periaqueductal gray

Helmstetter, F. J., & Landeira-Fernández, J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90343-a · Cited by 87 · see citing works

Endogenous opioids acting at a medullary μ-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray

Roychowdhury, S., & Fields, H. L. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00180-7 · Cited by 85 · see citing works

Microinfusion of mu but not delta or kappa opioid agonists into the basolateral amygdala results in inhibition of the tail flick reflex in pentobarbital-anesthetized rats.

Helmstetter, F. J., Bellgowan, P. S. F., & Poore, L. H. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12061-2 · Cited by 70 · see citing works

Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions

Abbadie, C., Lombard, M., Besson, J., Trafton, J. A., & Basbaum, A. I. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02242-4 · Cited by 68 · see citing works

Nocifensive responses to cutaneous thermal stimuli in the cat: stimulus-response profiles, latencies, and afferent activity

Casey, K. L., & Morrow, T. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.50.6.1497 · Cited by 61 · see citing works

Roles for Pain Modulatory Cells during Micturition and Continence

Baez, M. A., Brink, T. S., & Mason, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3536-04.2005 · Cited by 48 · see citing works

Opioid receptors in the ventral tegmental area contribute to stress-induced analgesia in the formalin test for tonic pain

Altier, N., & Stewart, J. (1996) · Brain Research · doi:10.1016/0006-8993(96)00121-7 · Cited by 42 · see citing works

Hypoalgesia elicited by a conditioned stimulus is blocked by a μ, but not a δ or a κ , opioid antagonist injected into the rostral ventromedial medulla

Foo, H., & Helmstetter, F. J. (1999) · Pain · doi:10.1016/s0304-3959(99)00125-6 · Cited by 35 · see citing works

Pain and emotion: a biopsychosocial review of recent research

Lumley, M. A., Cohen, J. L., Borszcz, G. S., Cano, A., Radcliffe, A. M., Porter, L. S., Schubiner, H., & Keefe, F. J. (2011) · Journal of Clinical Psychology · doi:10.1002/jclp.20816 · Cited by 836 · see citing works

A common neurobiology for pain and pleasure

Leknes, S., & Tracey, I. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2333 · Cited by 784 · see citing works

The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.

Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696 · see citing works

Music and social bonding: “self-other” merging and neurohormonal mechanisms

Tarr, B., Launay, J., & Dunbar, R. I. M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01096 · Cited by 548 · see citing works

Brain mediators of predictive cue effects on perceived pain

Atlas, L. Y., Bolger, N., Lindquist, M. A., & Wager, T. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0057-10.2010 · Cited by 389 · see citing works

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

Navratilova, E., Xie, J. Y., Okun, A., Qu, C., Eyde, N., Ci, S., Ossipov, M. H., King, T., Fields, H. L., & Porreca, F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214605109 · Cited by 313 · see citing works

Common brain mechanisms of chronic pain and addiction

Elman, I., & Borsook, D. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.027 · Cited by 303 · see citing works

Beyond happiness: Building a science of discrete positive emotions.

Shiota, M. N., Campos, B., Oveis, C., Hertenstein, M. J., Simon-Thomas, E. R., & Keltner, D. J. (2017) · American Psychologist · doi:10.1037/a0040456 · Cited by 279 · see citing works

Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain

Woo, C.-W., Roy, M., Buhle, J. T., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002036 · Cited by 263 · see citing works

Pain and suicidality: Insights from reward and addiction neuroscience

Elman, I., Borsook, D., & Volkow, N. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.003 · Cited by 220 · see citing works

Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways

Jhou, T. C., Good, C. H., Rowley, C. S., Xu, S., Wang, H., Burnham, N. W., Hoffman, A. F., Lupica, C. R., & Ikemoto, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3634-12.2013 · Cited by 198 · see citing works

The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context

Ellingsen, D., Leknes, S., Løseth, G. E., Wessberg, J., & Olausson, H. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01986 · Cited by 201 · see citing works

Synchrony as an Adaptive Mechanism for Large‐Scale Human Social Bonding

Launay, J., Tarr, B., & Dunbar, R. (2016) · Ethology · doi:10.1111/eth.12528 · Cited by 202 · see citing works

Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction

Jarcho, J. M., Mayer, E. A., Jiang, Z. K., Feier, N. A., & London, E. D. (2012) · Pain · doi:10.1016/j.pain.2012.01.002 · Cited by 160 · see citing works

Evaluation of reward from pain relief

Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12095 · Cited by 147 · see citing works

Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State

Goffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 142 · see citing works

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Burkett, J. P., Spiegel, L. L., Inoue, K., Murphy, A. Z., & Young, L. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.117 · Cited by 133 · see citing works

The Recurrent Pain and Sexual Sequelae of Provoked Vestibulodynia: A Perpetuating Cycle

Basson, R. J. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02803.x · Cited by 115 · see citing works

Lost but making progress—Where will new analgesic drugs come from?

Borsook, D., Hargreaves, R. J., Bountra, C., & Porreca, F. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008320 · Cited by 112 · see citing works

Neuronal Decision-Making Circuits

Kristan, W. B. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.081 · Cited by 109 · see citing works

Placebo improves pleasure and pain through opposite modulation of sensory processing

Ellingsen, D., Wessberg, J., Eikemo, M., Liljencrantz, J., Endestad, T., Olausson, H., & Leknes, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305050110 · Cited by 110 · see citing works

Behavioral choice by presynaptic inhibition of tactile sensory terminals

Gaudry, Q., & Kristan, W. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2400 · Cited by 108 · see citing works

Pain and the context

Carlino, E., Frisaldi, E., & Benedetti, F. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.17 · Cited by 108 · see citing works

Brain activity of anandamide: a rewarding bliss?

Scherma, M., Masia, P., Satta, V., Fratta, W., Fadda, P., & Tanda, G. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0075-x · Cited by 105 · see citing works

Different contexts, different pains, different experiences

Carlino, E., & Benedetti, F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.053 · Cited by 107 · see citing works

Cerebral interactions of pain and reward and their relevance for chronic pain

Becker, S., Gandhi, W., & Schweinhardt, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.013 · Cited by 103 · see citing works

Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain

Zhang, H., Qian, Y., Li, C., Liu, D., Wang, L., Wang, X., Liu, M., Liu, H., Zhang, S., Guo, X.-Y., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1180 · Cited by 101 · see citing works

Craving of Prescription Opioids in Patients With Chronic Pain: A Longitudinal Outcomes Trial

Wasan, A. D., Ross, E. L., Michna, E., Chibnik, L. B., Greenfield, S. F., Weiss, R. D., & Jamison, R. N. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.10.010 · Cited by 100 · see citing works

The Conundrum of Opioid Tapering in Long-Term Opioid Therapy for Chronic Pain: A Commentary

Manhapra, A., Arias, A. J., & Ballantyne, J. C. (2018) · Substance Abuse · doi:10.1080/08897077.2017.1381663 · Cited by 98 · see citing works

Sodium channels in pain disorders: pathophysiology and prospects for treatment

Dib‐Hajj, S. D., Geha, P., & Waxman, S. G. (2017) · Pain · doi:10.1097/j.pain.0000000000000854 · Cited by 99 · see citing works

The Positive Consequences of Pain: A Biopsychosocial Approach

Bastian, B., Jetten, J., Hornsey, M. J., & Leknes, S. (2014) · Personality and Social Psychology Review · doi:10.1177/1088868314527831 · Cited by 91 · see citing works

Orbitofrontal cortex mediates pain inhibition by monetary reward

Becker, S., Gandhi, W., Pomares, F. B., Wager, T. D., & Schweinhardt, P. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw173 · Cited by 92 · see citing works

Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction

Ellingsen, D., Isenburg, K., Jung, C. J., Lee, J., Gerber, J. A., Mawla, I., Sclocco, R., Jensen, K. B., Edwards, R. R., Kelley, J. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc1304 · Cited by 83 · see citing works

Evidence for endogenous opioid release in the amygdala during positive emotion

Koepp, M. J., Hammers, A., LAWRENCE, A., Asselin, M., Grasby, P. M., & Bench, C. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.032 · Cited by 82 · see citing works

The role of hedonics in the Human Affectome

Becker, S., Bräscher, A., Bannister, S., Bensafi, M., Calma‐Birling, D., Chan, R. C. K., Eerola, T., Ellingsen, D., Ferdenzi, C., Hanson, J. L., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.003 · Cited by 81 · see citing works

Facets and mechanisms of adaptive pain behavior: predictive regulation and action

Morrison, I., Perini, I., & Dunham, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00755 · Cited by 74 · see citing works

Integrative Model of Human-Animal Interactions: A One Health–One Welfare Systemic Approach to Studying HAI

Leconstant, C., & Spitz, É. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.656833 · Cited by 71 · see citing works

Temporal mismatch between pain behaviour, skin Nerve Growth Factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain

Evans, L. J., Loescher, A. R., Boissonade, F. M., Whawell, S. A., Robinson, P. P., & Andrew, D. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-1 · Cited by 68 · see citing works

Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening

Negri, A., Rives, M., Caspers, M. J., Prisinzano, T. E., Javitch, J. A., & Filizola, M. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400019t · Cited by 65 · see citing works

Pain in Times of Stress.

Ahmad, A. H., & Zakaria, R. (2015) · Europe PMC (PubMed Central) · Cited by 63 · see citing works

Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain

Gomtsian, L., Bannister, K., Eyde, N., Robles, D., Dickenson, A. H., Porreca, F., & Navratilova, E. (2018) · Pain · doi:10.1097/j.pain.0000000000001355 · Cited by 63 · see citing works

The role of dopamine in the perceptual modulation of nociceptive stimuli by monetary wins or losses

Becker, S., Gandhi, W., Elfassy, N. M., & Schweinhardt, P. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12303 · Cited by 60 · see citing works

Reduced Basal Ganglia μ-Opioid Receptor Availability in Trigeminal Neuropathic Pain: A Pilot Study

DosSantos, M. F. H., Martikainen, I. K., Nascimento, T. D., Love, T., Deboer, M. D., Maslowski, E., Monteiro, A. A., Vincent, M. B., Zubieta, J.-K., & DaSilva, A. F. M. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-74 · Cited by 57 · see citing works

Preemptive Stimulation of AgRP Neurons in Fed Mice Enables Conditioned Food Seeking under Threat

Jikomes, N., Ramesh, R. N., Mandelblat-Cerf, Y., & Andermann, M. L. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.019 · Cited by 57 · see citing works

Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization

Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0368-z · Cited by 54 · see citing works

Involvement of the nucleus accumbens and dopamine system in chronic pain

Benarroch, E. E. (2016) · Neurology · doi:10.1212/wnl.0000000000003243 · Cited by 52 · see citing works

Pain: A Distributed Brain Information Network?

Mano, H., & Seymour, B. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002037 · Cited by 66 · see citing works

Lysergic Acid Diethylamide and Psilocybin for the Management of Patients with Persistent Pain: a Potential Role?

Whelan, A., & Johnson, M. I. (2018) · Pain Management · doi:10.2217/pmt-2017-0068 · Cited by 51 · see citing works

Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens

Su, C. H., D’amour, J. A., Lee, M. S., Lin, H.-Y., Manders, T. R., Xu, D., Eberle, S. E., Goffer, Y., Zou, A., Rahman, M., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0140-z · Cited by 51 · see citing works

Endogenous opiates and behavior: 2007

Bodnar, R. J. (2008) · Peptides · doi:10.1016/j.peptides.2008.09.007 · Cited by 51 · see citing works

Psychological Processes in Chronic Pain: Influences of Reward and Fear Learning as Key Mechanisms – Behavioral Evidence, Neural Circuits, and Maladaptive Changes

Nees, F., & Becker, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.051 · Cited by 49 · see citing works

Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain

Botvinik‐Nezer, R., Petre, B., Čeko, M., Lindquist, M. A., Friedman, N. P., & Wager, T. D. (2024) · Nature Communications · doi:10.1038/s41467-024-50103-8 · Cited by 48 · see citing works

‘Naltrexone Blocks Endorphins Released when Dancing in Synchrony’

Tarr, B., Launay, J., Benson, C., & Dunbar, R. I. M. (2017) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-017-0067-y · Cited by 48 · see citing works

Altered prefrontal correlates of monetary anticipation and outcome in chronic pain

Martucci, K. T., Borg, N., MacNiven, K. H., Knutson, B. D., & Mackey, S. (2018) · Pain · doi:10.1097/j.pain.0000000000001232 · Cited by 42 · see citing works

Physical Pain as Pleasure: A Theoretical Perspective

Dunkley, C. R., Henshaw, C. D., Henshaw, S. K., & Brotto, L. A. (2019) · The Journal of Sex Research · doi:10.1080/00224499.2019.1605328 · Cited by 45 · see citing works

Methadone Antinociception Is Dependent on Peripheral Opioid Receptors

He, L., Kim, J., Ou, C. J., McFadden, W., van Rijn, R. M., & Whistler, J. L. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.09.011 · Cited by 42 · see citing works

Mechanisms for the Regulation of State Changes in the Central Nervous System

Pfaff, D. W., Kieffer, B. L., & Swanson, L. W. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.031 · Cited by 40 · see citing works

Behavioral and neurochemical analysis of ongoing bone cancer pain in rats

Remeniuk, B., Sukhtankar, D. D., Okun, A., Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2015) · Pain · doi:10.1097/j.pain.0000000000000218 · Cited by 40 · see citing works

Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction

Bodnar, R. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.04.008 · Cited by 39 · see citing works

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms

Cho, Y. W., Song, M. L., Earley, C. J., & Allen, R. P. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.024 · Cited by 38 · see citing works

Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain?

Nees, F., Becker, S., Millenet, S., Banaschewski, T., Poustka, L., Bokde, A. L. W., Bromberg, U., Büchel, C., Conrod, P., Desrivières, S., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000720 · Cited by 35 · see citing works

A Novel Role for the Periaqueductal Gray in Consummatory Behavior

Tryon, V. L., & Mizumori, S. J. Y. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00178 · Cited by 34 · see citing works

Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS)

Blum, K., Baron, D. A., McLaughlin, T., & Gold, M. S. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116733 · Cited by 38 · see citing works

Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain

Diaz, M. M., Caylor, J. R., Strigo, I. A., Lerman, I. R., Henry, B. L., López, E., Wallace, M. S., Ellis, R. J., Simmons, A. N., & Keltner, J. R. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.869215 · Cited by 35 · see citing works

Cognitive–Affective and Somatic Side Effects of Morphine and Pentazocine: Side-Effect Profiles in Healthy Adults

Riley, J. L., Hastie, B. A., Glover, T. L., Fillingim, R. B., Staud, R. M., & Campbell, C. M. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00680.x · Cited by 35 · see citing works

Cannabinoids, reward processing, and psychosis

Gunasekera, B., Diederen, K. M. J., & Bhattacharyya, S. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05801-2 · Cited by 33 · see citing works

Pharmacological Manipulation of the Rostromedial Tegmental Nucleus Changes Voluntary and Operant Ethanol Self-Administration in Rats

Fu, R., Zuo, W., Gregor, D. M., Li, J., Grech, D., & Ye, J.-H. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12974 · Cited by 33 · see citing works

Placebo analgesia: cognitive influences on therapeutic outcome

Watson, A., Power, A., Brown, C. A., El‐Deredy, W., & Jones, A. K. P. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3783 · Cited by 32 · see citing works

Neuroanatomical distribution of μ-opioid receptor mRNA and binding in monogamous prairie voles (Microtus ochrogaster) and non-monogamous meadow voles (Microtus pennsylvanicus)

Inoue, K., Burkett, J. P., & Young, L. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.035 · Cited by 31 · see citing works

Docking and Free Energy Perturbation Studies of Ligand Binding in the Kappa Opioid Receptor

Goldfeld, D. A., Murphy, R. B., Kim, B., Wang, L., Beuming, T., Abel, R., & Friesner, R. A. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp5053612 · Cited by 31 · see citing works

Opioid modulation of song in male zebra finches (Taenopygia guttata)

Khurshid, N., Jayaprakash, N., Hameed, L. S., Mohanasundaram, S., & Iyengar, S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.003 · Cited by 31 · see citing works

Pleasure-Related Analgesia Activates Opioid-Insensitive Circuits

Kut, E., Candia, V., von Overbeck, J., Pok, J., Fink, D., & Folkers, G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3736-10.2011 · Cited by 30 · see citing works

The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain

Al‐Khrasani, M., Lackó, E., Riba, P., Király, K. P., Sobor, M., Tímár, J., Mousa, S. A., Schäfer, M., & Fürst, S. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.018 · Cited by 30 · see citing works

Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain

Giri, A. K., & Hruby, V. J. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.856879 · Cited by 28 · see citing works

Paradoxical surrogate markers of dental injury-induced pain in the mouse

Gibbs, J. L., Urban, R., & Basbaum, A. I. (2013) · Pain · doi:10.1016/j.pain.2013.04.018 · Cited by 28 · see citing works

Is Chronic Pain a Disease?

Ballantyne, J. C., & Sullivan, M. D. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.05.001 · Cited by 25 · see citing works

Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons

Amo, R., Uchida, N., & Watabe‐Uchida, M. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.019 · Cited by 23 · see citing works

AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain

Su, C. H., Lin, H. Y., Yang, R., Xu, D., Lee, M., Pawlak, N., Norcini, M., Sideris, A., Recio‐Pinto, E., Huang, D., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001336 · Cited by 24 · see citing works

Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons

Yang, J., Xiao, Y., Li, L., He, Q., Li, M., & Shu, Y. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00317 · Cited by 24 · see citing works

Virtual Reality as a Pain Distraction Modality for Experimentally Induced Pain in a Chronic Pain Population: An Exploratory Study

Brown, P., Powell, W. A., Dansey, N., Al‐Abbadey, M., Stevens, B., & Powell, V. (2021) · Cyberpsychology Behavior and Social Networking · doi:10.1089/cyber.2020.0823 · Cited by 23 · see citing works

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent µ-/δ-opioid receptor antagonist, regulates obese-related factors in mice

Marczak, E. D., Jinsmaa, Y., Myers, P. H., Blankenship, T., Wilson, R., Balboni, G., Salvadori, S., & Lazarus, L. H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.041 · Cited by 22 · see citing works

Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain

Martucci, K. T., MacNiven, K. H., Borg, N., Knutson, B. D., & Mackey, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45961-y · Cited by 20 · see citing works

Decision Points: The Factors Influencing the Decision to Feed in the Medicinal Leech

Gaudry, Q., & Kristan, W. B. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00101 · Cited by 22 · see citing works

Distraction from pain depends on task demands and motivation

Vogel, T. A., Falk, C. F., Otto, A. R., & Roy, M. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001041 · Cited by 21 · see citing works

Variation in the μ-opioid receptor gene (OPRM1) and experiences of felt security in response to a romantic partner’s quarrelsome behavior

Tchalova, K., Sadikaj, G., Moskowitz, D. S., Zuroff, D. C., & Bartz, J. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0600-4 · Cited by 21 · see citing works

Pain in an era of armed conflicts: prevention and treatment for warfighters and civilian casualties

George, E., Elman, I., Becerra, L., Berg, S., & Borsook, D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.002 · Cited by 18 · see citing works

Endogenous opioids and feeding behavior: A decade of further progress (2004–2014). A Festschrift to Dr. Abba Kastin

Bodnar, R. J. (2015) · Peptides · doi:10.1016/j.peptides.2015.03.019 · Cited by 18 · see citing works

Evidence for dopaminergic involvement in endogenous modulation of pain relief

Desch, S., Schweinhardt, P., Seymour, B., Flor, H., & Becker, S. (2023) · eLife · doi:10.7554/elife.81436 · Cited by 17 · see citing works

Efeitos da estimulação cerebral profunda bilateral do núcleo subtalâmico sobre a sensibilidade e a dor em indivíduos com doença de Parkinson idiopática

Cury, R. G. (2015) · doi:10.11606/t.5.2015.tde-26102015-150231 · Cited by 18 · see citing works

Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition

Becker, S., Gandhi, W., Kwan, S., Ahmed, A., & Schweinhardt, P. (2015) · eNeuro · doi:10.1523/eneuro.0029-15.2015 · Cited by 17 · see citing works

Opioid modulation of cell proliferation in the ventricular zone of adult zebra finches (Taenopygia guttata)

Khurshid, N., Hameed, L. S., Mohanasundaram, S., & Iyengar, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-146746 · Cited by 16 · see citing works

Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study

Luo, Y., Yan, C., Huang, T., Fan, M., Liu, L., Zhao, Z., Ni, K., Jiang, H., Huang, X., Lu, Z., et al. (2016) · Pain Practice · doi:10.1111/papr.12358 · Cited by 16 · see citing works

Suicide and the opioid overdose crisis among American Indian and Alaska Natives: a storm on two fronts demanding swift action

Ivanich, J., Weckstein, J., Nestadt, P. S., Cwik, M. F., Walls, M. L., Haroz, E. E., O’Keefe, V. M., Goklish, N. A., & Barlow, A. (2021) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2021.1955895 · Cited by 18 · see citing works

The brain in pain.

Ahmad, A. H., & Aziz, C. B. A. (2014) · Europe PMC (PubMed Central) · Cited by 16 · see citing works

Screening for Addictive Disorders Within a Workers’ Compensation Clinic: An Exploratory Study

Parhami, I., Hyman, M. H., Siani, A., Lin, S., Collard, M., Garcia, J., Casaus, L. R., TSUANG, J. W., & FONG, T. W. (2011) · Substance Use & Misuse · doi:10.3109/10826084.2011.629705 · Cited by 14 · see citing works

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

DaSilva, A. F. M., Nascimento, T. D., Love, T., DosSantos, M. F. H., Martikainen, I. K., Kaplan, C. M., Deboer, M. D., Lucas, S. R., Bender, M. A., Koeppe, R. A., et al. (2014) · Journal of Visualized Experiments · doi:10.3791/50682 · Cited by 14 · see citing works

Opioid receptor blockade inhibits self-disclosure during a closeness-building social interaction

Tchalova, K., & MacDonald, G. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104559 · Cited by 12 · see citing works

COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer Survivors With Chronic Pain

Yang, M., Baser, R. E., Khanin, R., Autuori, I., Li, Q. S., Panageas, K. S., Orlow, I., & Mao, J. J. J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.05.005 · Cited by 14 · see citing works

How Accurate Appraisal of Behavioral Costs and Benefits Guides Adaptive Pain Coping

Gandhi, W., Morrison, I., & Schweinhardt, P. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00103 · Cited by 14 · see citing works

Pain in critically ill patients with substance use disorder or long-term opioid use for chronic pain.

Drew, D. J., & Marie, B. S. (2011) · AACN Advanced Critical Care · doi:10.1097/nci.0b013e318220c504 · Cited by 12 · see citing works

Mu Opioid Receptor Mediated Analgesia and Reward

Fields, H. L. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-993-2_10 · Cited by 14 · see citing works

Understanding opioid reward

Fields, H. L., & Margolis, E. B. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.01.002 · Cited by 432 · see citing works

State-dependent opioid control of pain

Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946 · see citing works

Probing the role of striatal mu opioid receptors in behavior reinforcement

Johnson, D. A. (2020) · eScholarship (California Digital Library)

An endogenous opioid circuit determines state-dependent appetitive behaviorPreprint

Castro, D. C., Oswell, C. S., Zhang, E. T., Pedersen, C. E., Piantadosi, S. C., Rossi, M. A., Hunker, A. C., Guglin, A., Morón, J. A., Zweifel, L. S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.10.430657 · Cited by 2 · see citing works