Cited by 65Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Pavlovian Conditioning With Ethanol: Sign‐Tracking (Autoshaping), Conditioned Incentive, and Ethanol Self‐Administration

Krank, Marvin D.·2003·Alcoholism: Clinical and Experimental Research

Abstract

Background: Conditioned incentive theories of addictive behavior propose that cues signaling a drug's reinforcing effects activate a central motivational state. Incentive motivation enhances drug‐taking and drug‐seeking behavior. We investigated the behavioral response to cues associated with ethanol and their interaction with operant self‐administration of ethanol. Methods: In two experiments, rats received operant training to press a lever for a sweetened ethanol solution. After operant training, the animals were given Pavlovian pairings of a brief and localized cue light with the sweetened ethanol solution (no lever present). Lever pressing for ethanol was then re‐established, and the behavioral effects of the cue light were tested during an ethanol self‐administration session. Results: The conditioned responses resulting from pairing cue lights with the opportunity to ingest ethanol had three main effects: (1) induction of operant behavior reinforced by ethanol, (2) stimulation of ethanol‐seeking behavior (magazine entries), and (3) signal‐directed behavior (i.e., autoshaping, or sign‐tracking). Signal‐directed behavior interacted with the other two effects in a manner predicted by the location of the cue light. These conditioned responses interact with operant responding for ethanol reinforcement. Conclusions: These findings demonstrate the importance of Pavlovian conditioning effects on ethanol self‐administration and are consistent with conditioned incentive theories of addictive behavior.

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Crossref · 10.1097/01.alc.0000092060.09228.de

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Authors
Krank, M. D.
Affiliations
Mount Allison University (CA)
Corresponding author
Krank, Marvin D.
Venue
Alcoholism: Clinical and Experimental Research
Publisher
Wiley
Published
2003-10
Volume
27
Issue
10
Pages
1592-1598
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
OpenAlex
W2078718526
Cited by
65
References
49
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
classical conditioning, ethanol self-administration, sign-tracking, autoshaping, incentive motivation, drug-seeking behavior, ethanol reinforcement, addictive behavior, rats
MeSH terms
Ethanol, Animals, Conditioning, Classical, Cues, Extinction, Psychological, Male, Motivation, Self Administration, Rats, Sprague-Dawley, Rats

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