Glucose, Glycation, and RAGE: Implications for Amplification of Cellular Dysfunction in Diabetic Nephropathy

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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RAGE Mediates a Novel Proinflammatory Axis

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S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles

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Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

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Advanced protein glycosylation in diabetes and aging

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Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

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Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases

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Endothelial dysfunction in diabetes

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Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

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The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

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Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

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Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

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Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

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The S100 family of EF-hand calcium-binding proteins: functions and pathology

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Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications

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The S100 protein family: History, function, and expression

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Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

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Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

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End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions

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Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

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Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker

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Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

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Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

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RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy

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Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

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Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

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Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

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N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins

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Expression of Advanced Glycation End Products and Their Cellular Receptor RAGE in Diabetic Nephropathy and Nondiabetic Renal Disease

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Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes.

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Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

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Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice

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Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

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Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.

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Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors

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Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat

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Antibodies against Vascular Endothelial Growth Factor Improve Early Renal Dysfunction in Experimental Diabetes

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Nε-(Carboxymethyl)lysine Protein Adduct Is a Major Immunological Epitope in Proteins Modified with Advanced Glycation End Products of the Maillard Reaction

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Breakers of advanced glycation end products restore large artery properties in experimental diabetes

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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.

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Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

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Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

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Advanced glycation end products increase retinal vascular endothelial growth factor expression.

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Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex

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Rage and arthritis: The G82S polymorphism amplifies the inflammatory response

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Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

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The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

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The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation

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Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

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Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

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An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness

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Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

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Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products.

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Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

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Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

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Receptor for Advanced Glycation End Products Mediates Inflammation and Enhanced Expression of Tissue Factor in Vasculature of Diabetic Apolipoprotein E–Null Mice

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The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

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Total, LDL, and HDL Cholesterol Decrease With Age in Older Men and Women

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Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation

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Increased transcapillary escape rate of albumin in Type 1 (insulin-dependent) diabetic patients with microalbuminuria

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Glycation induces expansion of the molecular packing of collagen

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AGEs induce oxidative stress and activate protein kinase C-βIIin neonatal mesangial cells

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Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen.

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Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

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Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors.

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Polyamine depletion arrests cell cycle and induces inhibitors p21 Waf1/Cip1 , p27 Kip1 , and p53 in IEC-6 cells

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Increased collagen-linked pentosidine levels and advanced glycosylation end products in early diabetic nephropathy.

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The dark side of glucose

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Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease.

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CD36, serves as a receptor for advanced glycation endproducts (AGE)

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Upregulation of Mesangial Growth Factor and Extracellular Matrix Synthesis by Advanced Glycation End Products Via a Receptor-Mediated Mechanism

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Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.

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