The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Ventilation of patients with acute lung injury and acute respiratory distress syndrome: Has new evidence changed clinical practice?*
Abstract
OBJECTIVES: A recent randomized trial of mechanical ventilation in acute lung injury (ALI)/adult respiratory distress syndrome (ARDS) demonstrated a 22% relative reduction in mortality rate using 6 mL/kg predicted body weight tidal volume vs. 12 mL/kg predicted body weight tidal volume. We determined whether publication of these findings changed clinical practice. DESIGN: Retrospective cohort, 12 months before (Pre) and 12 months after publication (Post) of a randomized trial supporting the use of a 6 mL/kg predicted body weight tidal volume strategy. SETTING: Three tertiary care hospitals in northern New England. PATIENTS: From a sample of 943 patients receiving prolonged mechanical ventilation between 1998 and 1999 (Pre) and between 2000 and 2001 (Post), 300 patients meeting the American-European Consensus Conference definition of ALI or ARDS were selected for analysis. INTERVENTIONS: The tidal volume, tidal volume/kg predicted body weight, and proportion receiving tidal volume/kg > or =6 mL/kg and < or =12 mL/kg predicted body weight were recorded at noon the first day after the diagnosis of ALI or ARDS was established. MEASUREMENTS AND MAIN RESULTS: Pre and Post mean tidal volume (+/- sd) size and tidal volume size/kg predicted body weight were 759 +/- 158 mL (median 750 mL) vs. 639 +/- 138 mL (median 600 mL, p <.001) and 12.3 +/- 2.7 mL/kg (median 11.7 mL/kg) vs. 10.6 +/- 2.4 mL/kg (median 10.7 mL/kg, p <.001) respectively. Pre and Post plateau pressures and peak airway pressures were similar. CONCLUSION: Publication of a trial demonstrating large mortality reductions using small tidal volume was associated with significant reductions in tidal volume delivered to patients with ALI/ARDS. However, wide variation in practice persists, and the proportion of patients receiving tidal volumes within recommended limits (< or =8 mL/kg) remains modest.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
BROCHARD, L., ROUDOT-THORAVAL, F., ROUPIE, E., DELCLAUX, C., CHASTRE, J., FERNANDEZ-MONDÉJAR, E., CLÉMENTI, E., MANCEBO, J., FACTOR, P., MATAMIS, D., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9801044 · Cited by 800
Eichacker, P. Q., Gerstenberger, E. P., Banks, S. M., Cui, X., & Natanson, C. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-956oc · Cited by 423
Matchar, D. B., Samsa, G. P., Cohen, S. J., Oddone, E. Z., & Jurgelski, A. E. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01131-2 · Cited by 141 · cited 1×
“(19) found that the tidal volume decreased only modestly after publication of the ARDSNet trial (the reduction they found was even smaller than the reduction we identified); the trend toward smaller tidal volumes actually started before the ARDSNet results were published (we saw no evidence of this in our own study: T…”
Result
Cited by
de Jonge, E., Peelen, L., Keijzers, P. J., Joore, H., de Lange, D., van der Voort, P. H., Bosman, R. J., de Waal, R. A., Wesselink, R., & de Keizer, N. F. (2008) · Critical Care · doi:10.1186/cc7150 · Cited by 425
High Tidal Volume and Positive Fluid Balance Are Associated With Worse Outcome in Acute Lung Injury
Sakr, Y., Vincent, J.-L., Reinhart, K., Groeneveld, J., Michalopoulos, A., Sprung, C. L., Artigas, A., & Ranieri, V. M. (2005) · Chest · doi:10.1378/chest.128.5.3098 · Cited by 405
Needham, D. M., Colantuoni, E., Mendez-Tellez, P. A., Dinglas, V. D., Sevransky, J. E., Dennison Himmelfarb, C. R., Desai, S. V., Shanholtz, C., Brower, R. G., & Pronovost, P. J. (2012) · BMJ · doi:10.1136/bmj.e2124 · Cited by 353
Dahlem, P., & Randolph, A. G. (2015) · Pediatric and Neonatal Mechanical Ventilation · doi:10.1007/978-3-642-01219-8_49 · Cited by 304
Needham, D. M., Yang, T., Dinglas, V. D., Mendez-Tellez, P. A., Shanholtz, C., Sevransky, J. E., Brower, R. G., Pronovost, P. J., & Colantuoni, E. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201409-1598oc · Cited by 255
Metadata
- Authors
- Young, M. P., Manning, H. L., Wilson, D. L., Mette, S. A., Riker, R. R., Leiter, J. C., Liu, S. K., Bates, J. T., & Parsons, P. E.
- Venue
- Critical Care Medicine
- Published
- 2004-06
- Volume
- 32
- Issue
- 6
- Pages
- 1260-1265
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W1991696816
- Cited by
- 189
- References
- 6
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ventilation of patients with acute lung injury and acute respiratory distress syndrome: Has new evidence changed clinical practice?*. https://app.cochat.ai/papers/10.1097/01.ccm.0000127784.54727.56
- The paper
- Young, M. P., Manning, H. L., Wilson, D. L., Mette, S. A., Riker, R. R., Leiter, J. C., Liu, S. K., Bates, J. T., & Parsons, P. E. (2004). Ventilation of patients with acute lung injury and acute respiratory distress syndrome: Has new evidence changed clinical practice?*. Critical Care Medicine. https://doi.org/10.1097/01.ccm.0000127784.54727.56
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
