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Cited by 180Exercise and Physiological ResponsesT-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Aerobic fitness is associated with lower proportions of senescent blood T-cells in man

Spielmann, Guillaume, McFarlin, Brian K., O’Connor, Daniel P., Smith, Paula J.W., Pircher, Hanspeter, Simpson, Richard J.·2011·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2011.07.226
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Abstract

Senescent T-cells accumulate with age, lowering the naïve T-cell repertoire and increasing host infection risk. As this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (VO(2max)) and the age-related accumulation of senescent T-cells. Blood lymphocytes from 102 healthy males (18-61 yr) were analyzed for KLRG1, CD57, CD28, CD45RA, CD45RO surface expression on CD4+ and CD8+ T-cells by 4-color flow cytometry. Advancing age (yr) was positively associated with the proportion (%) of senescent (KLRG1+/CD57+; KLRG1+/CD28-) CD4+ (B=1.00; 1.02) and CD8+ (B=0.429; 1.02) T-cells and inversely associated with naïve (KLRG1-/CD28+) CD4+ (B=-1.000) and CD8+ (B=-0.993) T-cells. VO(2max) was inversely associated with senescent CD4+ (B=-0.97) and CD8+ (B=-0.240). Strikingly, age was no longer associated with the proportions of senescent or naïve T-cells after adjusting for VO(2max), while the association between VO(2max) and these T-cell subsets withstood adjustment for age, BMI and percentage body fat. Ranking participants by age-adjusted VO(2max) revealed that the highest tertile had 17% more naïve CD8+ T-cells and 57% and 37% less senescent CD4+ and CD8+ T-cells, respectively, compared to the lowest tertile. VO(2max) was not associated with latent cytomegalovirus (CMV), Epstein-Barr virus (EBV) or herpes simplex virus-1 (HSV-1) infection, indicating that the moderating associations of VO(2max) were not confounded by persistent viral infections. This is the first study to show that aerobic fitness is associated with a lower age-related accumulation of senescent T-cells, highlighting the beneficial effects of maintaining a physically active lifestyle on the aging immune system.

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  • Fitter individuals exhibit a smaller age-associated decline in naive T cells and a smaller accumulation of late-stage differentiated T cells.

    “Thus, it was concluded that fitter individuals exhibit a smaller age-associated decline in naïve T cells and a smaller accumulation of late-stage differentiated T cells.”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Spielmann et al. 2011

  • The age-associated decrease in naive T cells and increase in late-stage differentiated T cells did not withstand statistical adjustment for cardiorespiratory fitness, suggesting ageing may be secondary to fitness in shaping the T cell repertoire.

    “Fascinatingly, the age-associated decrease in the proportion of naïve T cells and increase in the proportion of late-stage differentiated T cells, did not withstand statistical adjustment for cardiorespiratory fitness, suggesting that ageing may be secondary to fitness in shaping the T cell repertoire.”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Spielmann et al. 2011

  • In active individuals or those exposed to moderate-to-high volumes of exercise over a short period, exercise likely exerts an anti-immunosenescence effect in a dose-dependent manner until a certain threshold.

    “When examining individuals described as being active or those who have been exposed to moderate-to-high volumes of exercise over a short period of the lifespan (e.g., young adults), it is likely that exercise exerts an anti-immunosenescence effect in a dose-dependent manner until a certain threshold (Brown et al. 2014; Spielmann et al. 2011).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Spielmann et al. 2011

  • The percentage of the CD4+ and CD8+ T cell pool comprising late-stage differentiated T cells was inversely correlated with cardiorespiratory fitness in 102 males aged 18-61 years.

    “One of the first papers leading to, and providing experimental evidence for the hypothesis that “exercise makes immunological space”, showed that the percentage of the CD4+ and CD8+ T cell pool comprising late-stage differentiated T cells was inversely correlated with cardiorespiratory fitness (i.e., ) in 102 males aged 18–61 years (Spielmann et al. 2011).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Spielmann et al. 2011

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Authors
Spielmann, G., McFarlin, B. K., O’Connor, D. P., Smith, P. J. W., Pircher, H., & Simpson, R. J.
Affiliations
  • Edinburgh Napier University (GB)
  • University of Houston (US)
  • University of Freiburg (DE)
Corresponding author
Simpson, Richard J.
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2011-11
Volume
25
Issue
8
Pages
1521-1529
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2011.07.226
OpenAlex
W2079360446
Cited by
180
References
59
Citations by year
2026: 16 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 19 · 2021: 24 · 2020: 17 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 6
FWCI
8.43
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
cardiorespiratory fitness, VO2max, senescent T cells, T cell senescence, naive T cells, CD4+ T cells, CD8+ T cells, aging immune system, KLRG1, CD57, CD28, physical activity, lifestyle factors, viral infection
MeSH terms
Adolescent, Adult, Antigens, Surface, Body Composition, Cytomegalovirus Infections, Flow Cytometry, Herpes Simplex, Humans, Male, Middle Aged, Monocytes, Motor Activity, Physical Fitness, Regression Analysis, T-Lymphocytes, Anaerobic Threshold, Exercise, Body Mass Index, Cellular Senescence, Epstein-Barr Virus Infections, Young Adult

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