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Cited by 86Sleep and related disordersTreatment of Major DepressionSleep and Wakefulness Research

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effects of Sertraline on Sleep Architecture in Patients With Depression

Jindal, Ripu D., Friedman, Edward S., Berman, Susan R., Fasiczka, Amy L., Howland, Robert H., Thase, Michael E.·2003·Journal of Clinical Psychopharmacology
DOI 10.1097/01.jcp.0000095345.32154.9a
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Abstract

Previous studies indicate that selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, fluvoxamine, citalopram and paroxetine, suppress rapid eye movement sleep, and increased nocturnal arousals. There has been no published report of the impact of sertraline on the sleep of depressed patients. This study examines such effects. Forty-seven patients with major depressive disorder, randomized to double-blind treatment with sertraline or placebo, completed sleep studies before and after 12 weeks of pharmacotherapy. Groups were compared using multivariate analyses of covariance and/or analyses of covariance to examine 4 empirically defined sets of sleep measures. Compared to the placebo-treated group, patients who received sertraline experienced an increase in delta wave sleep in the first sleep cycle and prolonged rapid eye movement (REM) sleep latency. Although, sertraline therapy decreased the average number of REM periods (from 3.86 to 2.40), the activity of both REM period 1 and REM period 2 was significantly increased. Aside from an increase in sleep latency, sertraline therapy was not associated with a worsening of measures of sleep continuity. There was also no significant difference between the groups on a measure of subjective sleepiness. These findings are both similar and different from those observed in previous studies of other SSRIs. The increase in delta sleep ratio and consolidation of REM sleep may have some other clinical implications. However, th…

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  • There is a risk that a patient with depression and insomnia will not be able to stop combination treatment with benzodiazepines and SSRI/SNRI after 14-28 days and will develop dependence.

    “However, there is a related risk that the patient suffering from depression and insomnia will not be able to stop such treatment after 14 -28 days of therapy and will develop a dependence [21, 22].”

    From Effects of Antidepressants on Sleep (2017) · cites this paper as [21]

  • Sertraline (mean 142mg) suppressed REM sleep and increased sleep latency (although not significantly), compared to placebo.

    “(Jindal et al., 2003) found that sertraline (mean 142mg) suppressed REM sleep and increased sleep latency (although not significantly), compared to placebo.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Jindal et al., 2003

  • In RCTs, prolonged sleep latency and reduced sleep time have been noted with sertraline, fluoxetine, fluvoxamine and paroxetine, particularly when compared to placebo and against sedative TCAs.

    “In RCTs, prolonged sleep latency and reduced sleep time have been noted with sertraline (Jindal et al., 2003), fluoxetine (Gillin et al., 1997), fluvoxamine (Wilson et al., 2000) and paroxetine (Hicks et al., 2002), particularly when compared to placebo and against the sedative TCAs.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Jindal et al., 2003

Citations

Cites

  • REM sleep and the early development of posttraumatic stress disorder

    Mellman, T. A., Bustamante, V., Fins, A. I., Pigeon, W. R., & Nolan, B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1696 · Cited by 414 · cited 1×

    “For example, a recent study has demonstrated a pattern of fragmented REM sleep (ie, an increase in the total number of REM periods in a night) early in the development of posttraumatic stress disorder.(36) It would be interesting to see if sertraline therapy leads to consolidation of REM sleep in such patients and if…”
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Metadata

Authors
Jindal, R. D., Friedman, E. S., Berman, S. R., Fasiczka, A. L., Howland, R. H., & Thase, M. E.
Affiliations
University of Pittsburgh (US)
Corresponding author
Jindal, Ripu D.
ORCID
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-12
Volume
23
Issue
6
Pages
540-548
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/01.jcp.0000095345.32154.9a
OpenAlex
W2074779611
Cited by
86
References
1
Citations by year
2026: 9 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
3.63
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH041884, MH30915)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sertraline, sleep architecture, major depressive disorder, selective serotonin reuptake inhibitors, REM sleep, REM latency, delta sleep, sleep continuity, subjective sleepiness, insomnia, antidepressant side effects
MeSH terms
Adult, Major Depressive Disorder, Double-Blind Method, Electroencephalography, Female, Humans, Male, Middle Aged, Sleep, Polysomnography, Selective Serotonin Reuptake Inhibitors, Sertraline

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