Neuropathology of Parkinson disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium

McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,105 · see citing works

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004058 · Cited by 4,476 · see citing works

α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop

McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836 · see citing works

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529 · see citing works

Clinical diagnostic criteria for dementia associated with Parkinson’s disease

Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027 · see citing works

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,024 · see citing works

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737 · see citing works

Stages in the development of Parkinson’s disease-related pathology

Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works

α-synuclein locus duplication as a cause of familial Parkinson's disease

Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029 · see citing works

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Burré, J., Sharma, M., Tsetsenis, T., Buchman, V. L., Etherton, M. R., & Südhof, T. C. (2010) · Science · doi:10.1126/science.1195227 · Cited by 1,817 · see citing works

The substantia nigra of the human brain

Damier, P., Hirsch, É. C., Agid, Y., & Graybiel, A. M. (1999) · Brain · doi:10.1093/brain/122.8.1437 · Cited by 1,772 · see citing works

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

(1998) · Europe PMC (PubMed Central) · Cited by 1,594 · see citing works

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,501 · see citing works

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

Luk, K. C., Kehm, V. M., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M. ‐. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112457 · Cited by 1,087 · see citing works

Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder

Schenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996) · Neurology · doi:10.1212/wnl.46.2.388 · Cited by 1,083 · see citing works

A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly

Giasson, B. I., Murray, I. V. J., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008919200 · Cited by 1,080 · see citing works

The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity

Hansen, L., Salmon, D., Galasko, D., Masliah, E., Katzman, R., DeTeresa, R., Thal, L., Pay, M. M., Hofstetter, R., Klauber, M., et al. (1990) · Neurology · doi:10.1212/wnl.40.1.1 · Cited by 1,068 · see citing works

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M. T., Michel, P. P., Marquez, J., Prigent, A., Ruberg, M., Hirsch, É. C., & Agid, Y. (1997) · PubMed · Cited by 1,045 · see citing works

Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)

Papp, M. I., Kahn, J. E., & Lantos, P. L. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90219-0 · Cited by 991 · see citing works

Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria

Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972 · see citing works

Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

Boeve, B. F., Silber, M. H., Saper, C. B., Ferman, T. J., Dickson, D. W., Parisi, J. E., Benarroch, E. E., Ahlskog, J. E., Smith, G. E., Caselli, R., et al. (2007) · Brain · doi:10.1093/brain/awm056 · Cited by 959 · see citing works

A Clinicopathologic Study of 100 Cases of Parkinson's Disease

Hughes, A. J., Daniel, S. E., Blankson, S., & Lees, A. J. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540020018011 · Cited by 945 · see citing works

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q., & Lee, V. M.-Y. (2003) · Science · doi:10.1126/science.1082324 · Cited by 879 · see citing works

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal‐Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R., & McLean, P. J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-42 · Cited by 853 · see citing works

Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease

Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839 · see citing works

Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

Hughes, A. J., Daniel, S. E., & Lees, A. J. (2001) · Neurology · doi:10.1212/wnl.57.8.1497 · Cited by 807 · see citing works

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

Conway, K. A., Harper, J. D., & Lansbury, P. T. (2000) · Biochemistry · doi:10.1021/bi991447r · Cited by 786 · see citing works

Where Does Parkinson Disease Pathology Begin in the Brain?

Del Tredici, K., Rüb, U., de Vos, R. A. I., Bohl, J. R. E., & Braak, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.5.413 · Cited by 773 · see citing works

Dementia with Lewy bodies.

McKeith, I. G. (2004) · Europe PMC (PubMed Central) · Cited by 756 · see citing works

Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry

Hamilton, R. L. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00269.x · Cited by 754 · see citing works

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

Murphy, D. D., Rueter, S. M., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03214.2000 · Cited by 753 · see citing works

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. ‐. (1998) · Annals of Neurology · doi:10.1002/ana.410440324 · Cited by 686 · see citing works

Pathology of Parkinson’s disease

Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 682 · see citing works

Proteasomal function is impaired in substantia nigra in Parkinson’s disease

McNaught, K. S. P., & Jenner, P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01701-8 · Cited by 653 · see citing works

α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

Chen, L., & Feany, M. Β. (2005) · Nature Neuroscience · doi:10.1038/nn1443 · Cited by 614 · see citing works

Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe

Harding, A., Broe, G. A., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf033 · Cited by 608 · see citing works

A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03090.2002 · Cited by 598 · see citing works

Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease

Hurtig, H., Trojanowski, J., Galvin, J., Ewbank, D., Schmidt, M., Lee, V., Clark, C., Glosser, G., Stern, M., Gollomp, S., et al. (2000) · Neurology · doi:10.1212/wnl.54.10.1916 · Cited by 596 · see citing works

The parkinson's complex: Parkinsonism is just the tip of the iceberg

Langston, J. W. (2006) · Annals of Neurology · doi:10.1002/ana.20834 · Cited by 585 · see citing works

Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.

Gibb, W. R. G., & Lees, A. J. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.5.388 · Cited by 574 · see citing works

α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

Ostrerova, N., Petrucelli, L., Farrer, M. J., Mehta, N., Choi, P., Hardy, J., & Wolozin, B. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05782.1999 · Cited by 560 · see citing works

Basal forebrain neurons in the dementia of Parkinson disease

Whitehouse, P. J., Hedreen, J. C., White, C. L., & Price, D. L. (1983) · Annals of Neurology · doi:10.1002/ana.410130304 · Cited by 535 · see citing works

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533 · see citing works

Frontotemporal Lobar Degeneration

Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 504 · see citing works

Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Li, W., West, N. C., Colla, E., Pletniková, O., Troncoso, J. C., Marsh, L., Dawson, T. M., Jäkälä, P., Hartmann, T., Price, D. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406976102 · Cited by 473 · see citing works

NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains

Wakabayashi, K., Hayashi, S., Yoshimoto, M., Kudo, H., & Takahashi, H. (2000) · Acta Neuropathologica · doi:10.1007/pl00007400 · Cited by 439 · see citing works

Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

Perrin, R. J., Woods, W. S., Clayton, D. F., & George, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004851200 · Cited by 432 · see citing works

Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair

Rubinsztein, D. C., DiFiglia, M., Heintz, N., Nixon, R. A., Qin, Z., Ravikumar, B., Stefanis, L., & Tolkovsky, A. M. (2005) · Autophagy · doi:10.4161/auto.1.1.1513 · Cited by 424 · see citing works

A Structural and Functional Role for 11-mer Repeats in α-Synuclein and Other Exchangeable Lipid Binding Proteins

Bussell, R., & Eliezer, D. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00520-5 · Cited by 418 · see citing works

Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome

Williams, D. R., Holton, J. L., Strand, C., Pittman, A. M., de Silva, R., Lees, A. J., & Révész, T. (2007) · Brain · doi:10.1093/brain/awm104 · Cited by 415 · see citing works

Lewy bodies are ubiquitinated

Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687787 · Cited by 409 · see citing works

Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease?

Kosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401 · see citing works

Olfactory dysfunction in Parkinson's disease.

Hawkes, C. H., Shephard, B. C., & Daniel, S. E. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.5.436 · Cited by 399 · see citing works

β-Synuclein Inhibits α-Synuclein Aggregation

Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., & Masliah, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00462-7 · Cited by 398 · see citing works

Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication

Fuchs, J., Nilsson, C., Kachergus, J. M., Munz, M., Larsson, E., Schüle, B., Langston, J. W., Middleton, F. A., Ross, O. A., Hulihan, M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000254458.17630.c5 · Cited by 397 · see citing works

Parkinson Disease Neuropathology

Apaydın, H., Ahlskog, J. E., Parisi, J. E., Boeve, B. F., & Dickson, D. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.102 · Cited by 397 · see citing works

Pathology and Biology of the Lewy Body

Pollanen, M. S., Dickson, D. W., & Bergeron, C. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199305000-00001 · Cited by 396 · see citing works

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

Irizarry, M. C., Growdon, W., Gómez‐Isla, T., Newell, K. L., George, J. M., Clayton, D. F., & Hyman, B. T. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199804000-00005 · Cited by 394 · see citing works

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

Ishizawa, T., Mattila, P. M., Davies, P., Wang, D., & Dickson, D. W. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.389 · Cited by 391 · see citing works

The pedunculopontine nucleus in Parkinson's disease

Zweig, R. M., Jankel, W. R., Hedreen, J. C., Mayeux, R. P., & Price, D. L. (1989) · Annals of Neurology · doi:10.1002/ana.410260106 · Cited by 388 · see citing works

Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease

Kalia, L. V., Lang, A. E., Hazrati, L., Fujioka, S., Wszołek, Z. K., Dickson, D. W., Ross, O. A., Deerlin, V. M. V., Trojanowski, J. Q., Hurtig, H. I., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2704 · Cited by 385 · see citing works

Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis

Zijlmans, J. C. M., Daniel, S. E., Hughes, A. J., Révész, T., & Lees, A. J. (2004) · Movement Disorders · doi:10.1002/mds.20083 · Cited by 384 · see citing works

Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease

Halliday, G. M., Blumbergs, P. C., Cotton, R. G. H., Blessing, W. W., & Geffen, L. B. (1990) · Brain Research · doi:10.1016/0006-8993(90)90733-r · Cited by 366 · see citing works

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364 · see citing works

When DLB, PD, and PSP masquerade as MSA

Koga, S., Aoki, N., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Josephs, K. A., Wszołek, Z. K., Langston, J. W., & Dickson, D. W. (2015) · Neurology · doi:10.1212/wnl.0000000000001807 · Cited by 361 · see citing works

Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of α-Synucleinopathy

Uchikado, H., Lin, W.-L., DeLucia, M. W., & Dickson, D. W. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000225908.90052.07 · Cited by 359 · see citing works

Accumulation of Phosphorylated α-Synuclein in Aging Human Brain

Saito, Y., Kawashima, A., Ruberu, N. N., Fujiwara, H., Koyama, S., Sawabe, M., Arai, T., Nagura, H., Yamanouchi, H., Hasegawa, M., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.6.644 · Cited by 351 · see citing works

Post mortem studies in Parkinson’s disease — is it possible to detect brain areas for specific symptoms?

Jellinger, K. A. (1999) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6360-3_1 · Cited by 349 · see citing works

Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study

Aarsland, D., Perry, R., Brown, A. D., Larsen, J. O., & Ballard, C. G. (2005) · Annals of Neurology · doi:10.1002/ana.20635 · Cited by 347 · see citing works

Diffuse lewy body disease in Japan

Kosaka, K. (1990) · Journal of Neurology · doi:10.1007/bf00314594 · Cited by 335 · see citing works

α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects

Bloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 330 · see citing works

Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra

Rinne, J. O., Rummukainen, J., Paljärvi, L., & Rinne, U. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260107 · Cited by 330 · see citing works

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

Duda, J. E., Giasson, B. I., Mabon, M. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Annals of Neurology · doi:10.1002/ana.10279 · Cited by 329 · see citing works

Facilitation at single synapses probed with optical quantal analysis

Oertner, T. G., Sabatini, B. L., Nimchinsky, E. A., & Svoboda, K. (2002) · Nature Neuroscience · doi:10.1038/nn867 · Cited by 324 · see citing works

α‐Synuclein pathology does not predict extrapyramidal symptoms or dementia

Parkkinen, L., Kauppinen, T., Pirttilä, T., Autere, J. M., & Alafuzoff, I. I. (2004) · Annals of Neurology · doi:10.1002/ana.20321 · Cited by 315 · see citing works

Widespread Alterations of α-Synuclein in Multiple System Atrophy

Dickson, D. W., Liu, W.-K., Hardy, J., Farrer, M. J., Mehta, N. D., Uitti, R. J., Mark, M. H., Zimmerman, T., Golbe, L. I., Sage, J., et al. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65226-1 · Cited by 298 · see citing works

Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell

Berendse, H. W., Booij, J., Francot, C. M. J. E., Bergmans, P., Hijman, R., Stoof, J. C., & Wolters, E. C. (2001) · Annals of Neurology · doi:10.1002/ana.1049 · Cited by 298 · see citing works

Incidental Lewy body disease in a patient with REM sleep behavior disorder

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Parkinson disease and the gut: new insights into pathogenesis and clinical relevance

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Intestinal pathology and gut microbiota alterations in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

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Roles of Glutamate Receptors in Parkinson’s Disease

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Blinded RT‐QuIC Analysis of α‐Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients

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Copper and copper nanoparticles toxicity and their impact on basic functions in the body

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Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

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Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

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Modeling of presymptomatic and symptomatic stages of parkinsonism in mice

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Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

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The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses

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mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson’s disease

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Decreased AQP4 Expression Aggravates ɑ-Synuclein Pathology in Parkinson’s Disease Mice, Possibly via Impaired Glymphatic Clearance

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Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases

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Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models

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Parkinson’s disease: experimental models and reality

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Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges

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Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions

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Spatiotemporal EEG microstate analysis in drug-free patients with Parkinson's disease

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Molecular Imaging of the Dopamine Transporter

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MicroRNA Dysregulation in Parkinson’s Disease: A Narrative Review

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TREM2 deficiency aggravates α‐synuclein–induced neurodegeneration and neuroinflammation in Parkinson's disease models

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MRI biomarkers of motor and non-motor symptoms in Parkinson's disease

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The Cellular Environment Affects Monomeric α-Synuclein Structure

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The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury

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The Role of Diet and Dietary Patterns in Parkinson’s Disease

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Molecular chaperones and Parkinson's disease

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Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P)—A Clinical Challenge at the Boundaries of PSP and Parkinson's Disease (PD)

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NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective

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A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists

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Tau and MAPT genetics in tauopathies and synucleinopathies

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LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

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Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

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Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies

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Survey of Machine Learning Techniques in the Analysis of EEG Signals for Parkinson’s Disease: A Systematic Review

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The Basal Ganglia: More than just a switching device

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18F-AV-1451 in Parkinson’s Disease with and without dementia and in Dementia with Lewy Bodies

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Deep Learning Identifies Digital Biomarkers for Self-Reported Parkinson's Disease

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Lipid Nanoparticles: Promising Treatment Approach for Parkinson’s Disease

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Sedentary behavior and the biological hallmarks of aging

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Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism

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Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats

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Machine Learning Approaches for Detecting Parkinson’s Disease from EEG Analysis: A Systematic Review

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GLP-1 Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight

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Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson’s disease

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Automated Categorization of Parkinsonian Syndromes Using Magnetic Resonance Imaging in a Clinical Setting

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Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease

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Epigenetic modification in Parkinson’s disease

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Associations Between Diabetes Mellitus and Neurodegenerative Diseases

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Validation of differentially expressed brain‐enriched microRNAs in the plasma of PD patients

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The role of ferroptosis in neurodegenerative diseases

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IL‐1β/IL‐1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha‐Synuclein pathology in the olfactory bulb, substantia nigra and striatum

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Biomarker-guided decision making in clinical drug development for neurodegenerative disorders

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A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson’s disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study

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Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches

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Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson’s Disease

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The temporal onset of the core features in dementia with Lewy bodies

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Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease

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Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations

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PF-06649751 efficacy and safety in early Parkinson’s disease: a randomized, placebo-controlled trial

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The role of nutrition on Parkinson’s disease: a systematic review

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The Role of Magnetic Resonance Imaging for the Diagnosis of Atypical Parkinsonism

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Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease

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MPTP Mouse Model of Preclinical and Clinical Parkinson’s Disease as an Instrument for Translational Medicine

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Machine learning and deep learning for clinical data and PET/SPECT imaging in Parkinson's disease: a review

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Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model

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From the tyrosine hydroxylase hypothesis of Parkinson’s disease to modern strategies: a short historical overview

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Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype

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The Serotonergic Hypothesis for Depression in Parkinson's Disease: an Experimental Approach

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Emerging strategies, applications and challenges of targeting NAD+ in the clinic

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Classic and evolving animal models in Parkinson's disease

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Anti-Inflammatory Effects of Flavonoids in Common Neurological Disorders Associated with Aging

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Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

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Nanomaterials as Microglia Modulators in the Treatment of Central Nervous System Disorders

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Parkinson’s disease diagnosis using deep learning: A bibliometric analysis and literature review

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Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data

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Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”

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Microglial Turnover in Ageing-Related Neurodegeneration: Therapeutic Avenue to Intervene in Disease Progression

Azam, S., Haque, M. E., Kim, I., & Choi, D. (2021) · Cells · doi:10.3390/cells10010150 · Cited by 45 · see citing works

Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends

Moghaddasi, M., Oktay, B., Bingöl, A. B., Yanıkoglu, R., Muslu, M., Ozbolat, I. T., & Üstündağ, C. B. (2025) · Advanced Science · doi:10.1002/advs.202416085 · Cited by 45 · see citing works

Novel automated PD detection system using aspirin pattern with EEG signals

Barua, P. D., Doğan, Ş., Tuncer, T., Baygin, M., & Acharya, U. R. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104841 · Cited by 45 · see citing works

The Supplementary Motor Complex in Parkinson’s Disease

Rahimpour, S., Rajkumar, S., & Hallett, M. (2021) · Journal of Movement Disorders · doi:10.14802/jmd.21075 · Cited by 48 · see citing works

Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds

Silva, J. H. C. E., Ferreira, R. S., Pereira, É. P. L., Braga‐de‐Souza, S., de Almeida, M. M. A., dos Santos, C. C., Butt, A. M., Caiazzo, E., Capasso, R., da Silva, V. D. A., et al. (2020) · Molecules · doi:10.3390/molecules25153394 · Cited by 42 · see citing works

Regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases

Li, R., Wang, L., Duan, H., Zhang, Q., Guo, X., Wu, C., & Peng, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.937289 · Cited by 44 · see citing works

High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress

Bittencourt, A., Brum, P. O., Ribeiro, C. T., Gasparotto, J., Bortolin, R. C., de Vargas, A. R., Heimfarth, L., de Almeida, R. F., Moreira, J. C. F., de Oliveira, J., et al. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1831261 · Cited by 43 · see citing works

Diurnal rhythms across the human dorsal and ventral striatum

Ketchesin, K. D., Zong, W., Hildebrand, M. A., Seney, M. L., Cahill, K. M., Scott, M. R., Shankar, V. G., Glausier, J. R., Lewis, D. A., Tseng, G. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016150118 · Cited by 43 · see citing works

Effects of possible bisphenol A metabolites on rat spontaneous motor activity

Ishido, M., Masuo, Y., Terasaki, M., Edmonds, J., & Morita, M. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.07.1753

Neuropathology of α‐synuclein in Parkinson's disease

Choong, C., & Mochizuki, H. (2022) · Neuropathology · doi:10.1111/neup.12812 · Cited by 49 · see citing works

Neuropathology of Parkinson's Disease and ParkinsonismPreprint

Dickson, D. W. (2025) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041610 · Cited by 14 · see citing works

Neuropathology of Parkinson’s Disease

Jellinger, K. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-08046-8_2 · Cited by 30 · see citing works

Etiopathogenesis of Parkinson's Disease

Pardasani, V. (2026) · CRC Press eBooks · doi:10.1201/9781003505488-3 · Cited by 1 · see citing works