Cited by 146Schizophrenia research and treatmentSubstance Abuse Treatment and OutcomesHomelessness and Social Issues

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Substance Use in Persons With Schizophrenia: Baseline Prevalence and Correlates From the NIMH CATIE Study

Swartz, Marvin S., Wagner, H Ryan, Swanson, Jeffrey W., Stroup, T Scott, McEvoy, Joseph P., Canive, Jose M., Miller, Del D., Reimherr, Fred, McGee, Mark, Khan, Ahsan, Van Dorn, Richard, Rosenheck, Robert A., Lieberman, Jeffrey A.·2006·Journal of Nervous & Mental Disease

DOI 10.1097/01.nmd.0000202575.79453.6e

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Abstract

This study examined baseline correlates of substance use in the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness project. Approximately 60% of the sample was found to use substances, including 37% with current evidence of substance use disorders. Users (with and without substance use disorders), compared with nonusers, were significantly more likely to be male, be African-American, have lower educational attainment, have a recent period of homelessness, report more childhood conduct problems, have a history of major depression, have lower negative symptom and higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. Individuals with comorbid substance use disorders were significantly more likely to be male, report more childhood conduct problems, have higher positive symptom scores on the Positive and Negative Syndrome Scale, and have a recent illness exacerbation. These analyses suggest that substance use disorders in schizophrenia are especially common among men with a history of childhood conduct disorder problems and that childhood conduct disorder problems are potent risk factors for substance use disorders in schizophrenia.

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Authors: Swartz, M. S., Wagner, H. R., Swanson, J. W., Stroup, T. S., McEvoy, J. P., Canive, J. M., Miller, D. D., Reimherr, F., McGee, M., Khan, A., Van Dorn, R., Rosenheck, R. A., & Lieberman, J. A.
Affiliations: Duke University (US)
University of North Carolina at Chapel Hill (US)
University of Iowa (US)
University of Utah (US)
Corresponding author: Swartz, Marvin S.
Wagner, H Ryan
Swanson, Jeffrey W.
McEvoy, Joseph P.
Rosenheck, Robert A.
ORCID: Swartz, Marvin S.
Wagner, H Ryan
Swanson, Jeffrey W.
Stroup, T Scott
McEvoy, Joseph P.
Miller, Del D.
Rosenheck, Robert A.
Lieberman, Jeffrey A.
Venue: Journal of Nervous & Mental Disease
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-03
Volume: 194
Issue: 3
Pages: 164-172
ISSN: 0022-3018 (ISSN-L)
DOI: 10.1097/01.nmd.0000202575.79453.6e
OpenAlex: W2093348590
Cited by: 146
References: 37
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 13
FWCI: 10.60
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Nervous and Mental Disease (publishedVersion)
PubMed (publishedVersion)
Funders: Eli Lilly and Company
Pfizer
University of Missouri
National Institutes of Health (n01mh90001-21-0-0)
National Institute of Mental Health (N01 MH90001)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Sociology and Political Science › Homelessness and Social Issues
Keywords: schizophrenia, substance use disorders, comorbidities, child conduct problems, risk factors, negative symptoms, positive symptoms, homelessness, major depressive disorder, African American men, educational attainment
MeSH terms: Cross-Sectional Studies, Double-Blind Method, Female, Humans, Male, Piperazines, Risk Factors, Schizophrenia, Schizophrenic Psychology, Sex Factors, Thiazoles, Antipsychotic Agents, United States, Multicenter Studies as Topic, Comorbidity, Prevalence, Randomized Controlled Trials as Topic, Treatment Outcome, Diagnosis, Dual (Psychiatry), Conduct Disorder, Substance-Related Disorders

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Substance Use in Persons With Schizophrenia: Baseline Prevalence and Correlates From the NIMH CATIE Study

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