The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure
Open accessAbstract
In Brief Objective: The HepatAssist liver support system is an extracorporeal porcine hepatocyte-based bioartificial liver (BAL). The safety and efficacy of the BAL were evaluated in a prospective, randomized, controlled, multicenter trial in patients with severe acute liver failure. Summary Background Data: In experimental animals with acute liver failure, we demonstrated beneficial effects of the BAL. Similarly, Phase I trials of the BAL in acute liver failure patients yielded promising results. Methods: A total of 171 patients (86 control and 85 BAL) were enrolled. Patients with fulminant/subfulminant hepatic failure and primary nonfunction following liver transplantation were included. Data were analyzed with and without accounting for the following confounding factors: liver transplantation, time to transplant, disease etiology, disease severity, and treatment site. Results: For the entire patient population, survival at 30 days was 71% for BAL versus 62% for control (P = 0.26). After exclusion of primary nonfunction patients, survival was 73% for BAL versus 59% for control (n = 147; P = 0.12). When survival was analyzed accounting for confounding factors, in the entire patient population, there was no difference between the 2 groups (risk ratio = 0.67; P = 0.13). However, survival in fulminant/subfulminant hepatic failure patients was significantly higher in the BAL compared with the control group (risk ratio = 0.56; P = 0.048). Conclusions: This is the first prospective, randomized, controlled trial of an extracorporeal liver support system, demonstrating safety and improved survival in patients with fulminant/subfulminant hepatic failure. A prospective randomized trial of the HepatAssist bioartificial liver support system was carried out in patients with fulminant/subfulminant hepatic failure and primary nonfunction following liver transplantation. Treated fulminant/subfulminant hepatic failure patients had improved survival compared with controls when the effect of confounding factors was accounted for in the data analysis.
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Cites
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Pilot–Controlled Trial of the Extracorporeal Liver Assist Device in Acute Liver Failure
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Self-citationHigh Volume Plasma Exchange in Fulminant Hepatic Failure
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EXTRACORPOREAL LIVER PERFUSION USING HUMAN AND PIG LIVERS FOR ACUTE LIVER FAILURE
Horslen, S. P., Hammel, J. M., Fristoe, L. W., Kangas, J. A., Collier, D. S., Sudan, D. L., Langnas, A. N., Dixon, R. S., Prentice, E. D., Shaw, B. W., et al. (2000) · Transplantation · doi:10.1097/00007890-200011270-00014 · Cited by 93
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Recent advances in three‐dimensional multicellular spheroid culture for biomedical research
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EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure
Wendon, J., Cordoba, J., Dhawan, A., Larsen, F. S., Manns, M., Nevens, F., Samuel, D., Simpson, K. J., Yaron, I., & Bernardi, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.003 · Cited by 917
Larsen, F. S., Schmidt, L. E., Bernsmeier, C., Rasmussen, A., Isoniemi, H., Patel, V. C., Triantafyllou, E., Bernal, W., Auzinger, G., Shawcross, D., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.018 · Cited by 659
Szczepiorkowski, Z. M., Winters, J. L., Bandarenko, N., Kim, H. C., Linenberger, M. L., Marques, M. B., Sarode, R., Schwartz, J., Weinstein, R., & Shaz, B. H. (2010) · Journal of Clinical Apheresis · doi:10.1002/jca.20240 · Cited by 508
Metadata
- Authors
- Demetriou, A. A., Brown, R. S., Busuttil, R. W., Fair, J., McGuire, B. M., Rosenthal, P., Am Esch, J. S., Lerut, J., Nyberg, S. L., Salizzoni, M., Fagan, E. A., de Hemptinne, B., Broelsch, C. E., Muraca, M., Salmeron, J. M., Rabkin, J. M., Metselaar, H. J., Pratt, D., De La Mata, M., McChesney, L. P., Everson, G. T., Lavin, P. T., Stevens, A. C., Pitkin, Z., & Solomon, B. A.
- Venue
- Annals of Surgery
- Published
- 2004-05
- Volume
- 239
- Issue
- 5
- Pages
- 660-670
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W1971200468
- Cited by
- 677
- References
- 13
- FWCI
- 31.31
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Demetriou, A. A., Brown, R. S., Busuttil, R. W., Fair, J., McGuire, B. M., Rosenthal, P., Am Esch, J. S., Lerut, J., Nyberg, S. L., Salizzoni, M., Fagan, E. A., de Hemptinne, B., Broelsch, C. E., Muraca, M., Salmeron, J. M., Rabkin, J. M., Metselaar, H. J., Pratt, D., De La Mata, M., . . . Solomon, B. A. (2004). Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure. Annals of Surgery. https://doi.org/10.1097/01.sla.0000124298.74199.e5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
