The intestinal microbiota and host immune interactions in the critically ill
Open accessAbstract
The gastrointestinal tract harbors a complex population of microbes that play a fundamental role in the development of the immune system and human health. Besides an important local contribution in the host defense against infections, it has become increasingly clear that intestinal bacteria also modulate immune responses at systemic sites. These new insights can be of profound clinical relevance especially for intensive care medicine where the majority of patients are treated with antibiotics, which have pervasive and long-term effects on the intestinal microbiota. Moreover, considerable progress has been made in defining the role of the intestinal microbiota in both health and disease. In this review, we highlight these aspects and focus on recent key findings addressing the role of intestinal microbiota in antimicrobial defense mechanisms and its impact on intestinal homeostasis in the critically ill.
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Self-citation
- Authors
- Schuijt, T. J., van der Poll, T., de Vos, W. M., & Wiersinga, W. J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Schuijt, Tim J.
- ORCID
- Wiersinga, W. Joost
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 21
- Issue
- 5
- Pages
- 221-229
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W1964968781
- Cited by
- 123
- References
- 81
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- ZonMw
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, critically ill patients, intensive care, antibiotics, antimicrobial defense, intestinal homeostasis, systemic immune response, gut-immune axis
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Drug Therapy, Humans, Immunity, Intestines, Critical Illness, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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