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Cited by 133Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressClinical Nutrition and Gastroenterology

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Vitamin C supplementation in the critically ill patient

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Berger, Mette M., Oudemans-van Straaten, Heleen M.·2015·Current Opinion in Clinical Nutrition and Metabolic Care
DOI 10.1097/mco.0000000000000148
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Abstract

PURPOSE OF REVIEW: Vitamin C is not only an essential nutrient involved in many anabolic pathways, but also an important player of the endogenous antioxidant defense. Low plasma levels are very common in critical care patients and may reflect severe deficiency states. RECENT FINDINGS: Vitamin C scavenges reactive oxygen species such as superoxide and peroxynitrite in plasma and cells (preventing damage to proteins, lipids and DNA), prevents occludin dephosphorylation and loosening of the tight junctions. Ascorbate improves microcirculatory flow impairment by inhibiting tumor-necrosis-factor-induced intracellular adhesion molecule expression, which triggers leukocyte stickiness and slugging. Clinical trials in sepsis, trauma and major burns testing high-dose vitamin C show clinical benefit. Restoration of normal plasma levels in inflammatory patients requires the administration of 3 g/day for several days, which is 30 times the daily recommended dose. SUMMARY: The recent research on the modulation of oxidative stress and endothelial protection offer interesting therapeutic perspectives, based on the biochemical evidence, with limited or even absent side-effects.

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Metadata

Authors
Berger, M. M., & Oudemans-van Straaten, H. M.
Affiliations
Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author
Berger, Mette M.
ORCID
Berger, Mette M.
Venue
Current Opinion in Clinical Nutrition and Metabolic Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-03
Volume
18
Issue
2
Pages
193-201
ISSN
1363-1950 (ISSN-L)
DOI
10.1097/mco.0000000000000148
OpenAlex
W2314267398
Cited by
133
References
6
Citations by year
2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 22 · 2018: 18 · 2017: 11 · 2016: 13
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
vitamin C, vitamin C supplementation, critically ill patients, oxidative stress, antioxidant defense, reactive oxygen species, superoxide, peroxynitrite, tight junctions, microcirculation, leukocyte adhesion, sepsis, trauma (physical injury), burns, high-dose vitamin C, plasma vitamin C levels, endothelial protection
MeSH terms
Ascorbic Acid, Ascorbic Acid Deficiency, Burns, Critical Care, Humans, Vitamins, Wounds and Injuries, Critical Illness, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Nutrition Therapy

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