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Cited by 53Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorElectroconvulsive Therapy Studies

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Increased Reactivity of the Mesolimbic Reward System after Ketamine Injection in Patients with Treatment-resistant Major Depressive Disorder

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Sterpenich, Virginie, Vidal, Sonia, Hofmeister, Jeremy, Michalopoulos, Giorgio, Bancila, Victor, Warrot, Delphine, Dayer, Alexandre, Desseilles, Martin, Aubry, Jean-Michel, Kosel, Markus, Schwartz, Sophie, Vutskits, Laszlo·2019·Anesthesiology
DOI 10.1097/aln.0000000000002667
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Abstract

Editor’s Perspective: What We Already Know about This Topic: What This Article Tells Us That Is New: Background: Ketamine rapidly improves maladaptive mood states in major depressive disorder, and some of the neural substrates underlying this therapeutic effect have been identified. This study aimed to identify functional changes within neural networks that may underlie the impact of ketamine on both reward and emotional processing in patients with treatment-resistant major depression. Methods: Ten adult patients with a Montgomery–Åsberg Depression Rating Scale score above 25 were enrolled to receive a single intravenous administration of ketamine (0.5 mg/kg). Patients’ performance along with related neural network activations were analyzed in a game-like reward task and in an emotional judgment task using functional magnetic resonance imaging 1 day before and 1 and 7 days after ketamine administration. Results: A significant correlation (R 2 = 0.46, P = 0.03) between the improvement of depression scores and the enhanced reaction time for positive items was found in the game-like reward task 1 day after ketamine administration. This enhanced sensitivity for rewarded items was accompanied by increased activity of reward-related brain regions, including the orbitofrontal cortex, ventral striatum, and the ventral tegmental area, an effect that persisted up to 1 week after ketamine injection. In the emotional judgment task, it was found that ketamine rapidly modified local brain activities in response to emotionally negative, positive, or neutral stimuli in the amygdala, insula, anterior cingulate cortex, and in the ventral tegmental area. Conclusions: Single bolus ketamine administration rapidly triggers lasting changes in mesolimbic neural networks to improve pathologic reward and emotional processing in patients with major depressive disorder.

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  1. 2005, Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication., Arch Gen Psychiatry, 62, 617, 10.1001/archpsyc.62.6.617 · DOI · Paper page
  2. 2012, A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression., Neuroimage, 61, 677, 10.1016/j.neuroimage.2012.04.005 · DOI
  3. 2015, Dimensional psychiatry: Reward dysfunction and depressive mood across psychiatric disorders., Psychopharmacology (Berl), 232, 331, 10.1007/s00213-014-3662-7 · DOI
  4. 2006, Emotional information processing in mood disorders: A review of behavioral and neuroimaging findings., Curr Opin Psychiatry, 19, 34, 10.1097/01.yco.0000191500.46411.00 · DOI · Paper page
  5. 2013, Emotional valence modulates brain functional abnormalities in depression: Evidence from a meta-analysis of fMRI studies., Neurosci Biobehav Rev, 37, 152, 10.1016/j.neubiorev.2012.11.015 · DOI · Paper page
  6. 2004, Antidepressants and the risk of suicidal behaviors., JAMA, 292, 338, 10.1001/jama.292.3.338 · DOI
  7. 2000, Antidepressant effects of ketamine in depressed patients., Biol Psychiatry, 47, 351, 10.1016/S0006-3223(99)00230-9 · DOI · Paper page
  8. 2006, A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression., Arch Gen Psychiatry, 63, 856, 10.1001/archpsyc.63.8.856 · DOI · Paper page
  9. 2015, The use of ketamine as an antidepressant: A systematic review and meta-analysis., Hum Psychopharmacol, 30, 152, 10.1002/hup.2475 · DOI · Paper page
  10. 2013, Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: A preliminary positron emission tomography study., Biol Psychiatry, 73, 1213, 10.1016/j.biopsych.2013.02.008 · DOI · Paper page
  11. 2014, Neural correlates of rapid antidepressant response to ketamine in bipolar disorder., Bipolar Disord, 16, 119, 10.1111/bdi.12118 · DOI
  12. 2014, Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression., Transl Psychiatry, 4, e469, 10.1038/tp.2014.105 · DOI · Paper page
  13. 2015, Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder., Transl Psychiatry, 5, e509, 10.1038/tp.2015.10 · DOI · Paper page
  14. 2017, Ketamine Treatment and Global Brain Connectivity in Major Depression., Neuropsychopharmacology, 42, 1210, 10.1038/npp.2016.186 · DOI · Paper page
  15. 2000, FMRI visualization of brain activity during a monetary incentive delay task., Neuroimage, 12, 20, 10.1006/nimg.2000.0593 · DOI · Paper page
  16. 2014, Ability to maintain internal arousal and motivation modulates brain responses to emotions., PLoS One, 9, e112999, 10.1371/journal.pone.0112999 · DOI
  17. 2002, Emotion and motivation: The role of the amygdala, ventral striatum, and prefrontal cortex., Neurosci Biobehav Rev, 26, 321, 10.1016/S0149-7634(02)00007-6 · DOI · Paper page
  18. 2002, Neural systems for recognizing emotion., Curr Opin Neurobiol, 12, 169, 10.1016/S0959-4388(02)00301-X · DOI · Paper page
  19. 2012, Evolution of human emotion: A view through fear., Prog Brain Res, 195, 431, 10.1016/B978-0-444-53860-4.00021-0 · DOI
  20. 2010, Dopaminergic reward system: A short integrative review., Int Arch Med, 3, 24, 10.1186/1755-7682-3-24 · DOI
  21. 2013, World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects., JAMA, 310, 2191, 10.1001/jama.2013.281053 · DOI · Paper page
  22. 2018, Efficacy and safety of a rapid intravenous injection of ketamine 0.5 mg/kg in treatment-resistant major depression: An open 4-week longitudinal study., J Clin Psychopharmacol, 38, 590, 10.1097/JCP.0000000000000960 · DOI
  23. 1979, A new depression scale designed to be sensitive to change., Br J Psychiatry, 134, 382, 10.1192/bjp.134.4.382 · DOI · Paper page
  24. 1960, A rating scale for depression., J Neurol Neurosurg Psychiatry, 23, 56, 10.1136/jnnp.23.1.56 · DOI · Paper page
  25. 1994, Measuring emotion: The self-assessment manikin and the semantic differential., J Behav Ther Exp Psychiatry, 25, 49, 10.1016/0005-7916(94)90063-9 · DOI · Paper page
  26. 2002, Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain., Neuroimage, 15, 273, 10.1006/nimg.2001.0978 · DOI · Paper page
  27. 2008, BOLD responses reflecting dopaminergic signals in the human ventral tegmental area., Science, 319, 1264, 10.1126/science.1150605 · DOI · Paper page
  28. 2001, Dissociation of reward anticipation and outcome with event-related fMRI., Neuroreport, 12, 3683, 10.1097/00001756-200112040-00016 · DOI · Paper page
  29. 2008, Neural responses to monetary incentives in major depression., Biol Psychiatry, 63, 686, 10.1016/j.biopsych.2007.07.023 · DOI · Paper page
  30. 2014, What can the monetary incentive delay task tell us about the neural processing of reward and punishment., NAN, 3:33–45
  31. 2011, Motivation and movement: The effect of monetary incentive on performance speed., Exp Brain Res, 209, 551, 10.1007/s00221-011-2583-5 · DOI
  32. 2004, Memory accessibility, mood regulation, and dysphoria: Difficulties in repairing sad mood with happy memories?, J Abnorm Psychol, 113, 179, 10.1037/0021-843X.113.2.179 · DOI
  33. 1994, Reward fails to alter response bias in depression., J Abnorm Psychol, 103, 460, 10.1037/0021-843X.103.3.460 · DOI
  34. 2014, A universal role of the ventral striatum in reward-based learning: Evidence from human studies., Neurobiol Learn Mem, 114, 90, 10.1016/j.nlm.2014.05.002 · DOI
  35. 2010, The neural code of reward anticipation in human orbitofrontal cortex., Proc Natl Acad Sci USA, 107, 6010, 10.1073/pnas.0912838107 · DOI · Paper page
  36. 2015, Reduction in ventral striatal activity when anticipating a reward in depression and schizophrenia: A replicated cross-diagnostic finding., Front Psychol, 6, 1280
  37. 2012, Long-term effects of nucleus accumbens deep brain stimulation in treatment-resistant depression: Evidence for sustained efficacy., Neuropsychopharmacology, 37, 1975, 10.1038/npp.2012.44 · DOI · Paper page
  38. 2005, Ketamine induces dopamine-dependent depression of evoked hippocampal activity in the nucleus accumbens in freely moving rats., J Neurosci, 25, 524, 10.1523/JNEUROSCI.3800-04.2005 · DOI
  39. 2013, Ketamine increases striatal dopamine release and hyperlocomotion in adult rats after postnatal functional blockade of the prefrontal cortex., Behav Brain Res, 256, 229, 10.1016/j.bbr.2013.08.017 · DOI
  40. 2007, Selective attention to emotional faces following recovery from depression., J Abnorm Psychol, 116, 80, 10.1037/0021-843X.116.1.80 · DOI · Paper page
  41. 2011, Neural mechanisms of the cognitive model of depression., Nat Rev Neurosci, 12, 467, 10.1038/nrn3027 · DOI · Paper page
  42. 2012, Cognitive mechanisms of treatment in depression., Neuropsychopharmacology, 37, 117, 10.1038/npp.2011.183 · DOI · Paper page

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Metadata

Authors
Sterpenich, V., Vidal, S., Hofmeister, J., Michalopoulos, G., Bancila, V., Warrot, D., Dayer, A., Desseilles, M., Aubry, J.-M., Kosel, M., Schwartz, S., & Vutskits, L.
Affiliations
University of Geneva (CH)
ORCID
Venue
Anesthesiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-06
Volume
130
Issue
6
Pages
923-935
ISSN
0003-3022 (ISSN-L)
DOI
10.1097/aln.0000000000002667
OpenAlex
W2937452922
Cited by
53
References
8
Citations by year
2026: 2 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 2
FWCI
3.72
Type
journal article
Language
en
Open access
Locations
  • Anesthesiology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • Repository of the University of Namur (submittedVersion, cc-by-nc-nd)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Université de Genève
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
ketamine, mesolimbic reward system, reward processing, emotional processing, orbitofrontal cortex, ventral striatum, ventral tegmental area, amygdala, emotional judgment, rapid-acting antidepressants, neuroplasticity, mood improvement, insula, anterior cingulate cortex
MeSH terms
Adult, Anesthetics, Dissociative, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Ketamine, Limbic System, Male, Middle Aged, Photic Stimulation, Pilot Projects, Reward, Depressive Disorder, Treatment-Resistant, Administration, Intravenous

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