Desflurane selectively suppresses long-latency cortical neuronal response to flash in the rat

Hudetz, Anthony G.; Vizuete, Jeannette A.; Imas, Olga A.

doi:10.1097/aln.0b013e3181ab671e

Cited by 68Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity ResearchNeural dynamics and brain function

Desflurane selectively suppresses long-latency cortical neuronal response to flash in the rat

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Hudetz, Anthony G., Vizuete, Jeannette A., Imas, Olga A.·2009·Anesthesiology

DOI 10.1097/aln.0b013e3181ab671ePMC PMC2761678

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Abstract

Background: The effect of inhalational anesthetics on sensory-evoked unit activity in the cerebral cortex has been controversial. Desflurane has desirable properties for in vivo neurophysiologic studies, but its effect on cortical neuronal activity and neuronal responsiveness is not known. The authors studied the effect of desflurane on resting and visual evoked unit activity in rat visual cortex in vivo. Methods: Desflurane was administered to adult albino rats at steady-state concentrations at 2%, 4%, 6%, and 8%. Flashes from a light emitting diode were delivered to the left eye at 5-s intervals. Extracellular unit activity within the right visual cortex was recorded using a 49-electrode array. Individual units were identified using principal components analysis. Results: At 2% desflurane, 578 active units were found. Of these, 75% increased their firing rate in response to flash. Most responses contained early (0-100 ms) and late (150-1000 ms) components. With increasing desflurane concentration, the number of units active at baseline decreased (-13%), the number of early-responding units increased (+31%), and number of late-responding units decreased (-15%). Simultaneously, baseline firing rate decreased (-77%), the early response was unchanged, and the late response decreased (-60%). Conclusions: The results indicate that visual cortex neurons remain responsive to flash stimulation under desflurane anesthesia, but the long-latency component of their response is attenuated in a concentration-dependent manner. Suppression of the long-latency response may be related to a loss of corticocortical feedback and loss of consciousness.

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Basic science studies of neural spike activity focusing on visual-evoked potentials confirmed the preferential susceptibility of long-latency potentials to anesthesia.
“This has been explicitly confirmed in more detailed basic science studies of neural spike activity, with a specific focus on visual-evoked potentials (Hudetz et al., 2009).”
From Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) · cites this paper as Hudetz et al., 2009
The Discussion (Mechanism anesthesia) reports that desflurane attenuated the long-latency neuronal response to flash while initial visual-cortex reactivity persisted. But the Discussion (Early response to flash) distinguishes the study’s intracortical unit recordings from visual-evoked potentials; the study does not establish preferential suppression of the potentials themselves. (LLM, conf=0.84)
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Authors: Hudetz, A. G., Vizuete, J. A., & Imas, O. A.
Affiliations: Professor of Anesthesiology, Physiology, and Biophysics.
Marquette University (US)
Medical College of Wisconsin (US)
ORCID: Hudetz, Anthony G.
Venue: Anesthesiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-08-01
Volume: 111
Issue: 2
Pages: 231-239
ISSN: 0003-3022 (ISSN-L)
DOI: 10.1097/aln.0b013e3181ab671e
PMC: PMC2761678
OpenAlex: W1994450638
Cited by: 68
References: 62
Citations by year: 2024: 4 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 5
FWCI: 5.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Anesthesiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
e-Publications@Marquette (Marquette University) (submittedVersion)
Funders: National Institute of General Medical Sciences (R01GM056398, R01 GM-56398)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: desflurane, inhalational anesthetics, visual cortex, flash stimulation, loss of consciousness
MeSH terms: Desflurane, Animals, Data Interpretation, Statistical, Dose-Response Relationship, Drug, Evoked Potentials, Visual, Isoflurane, Functional Laterality, Male, Neurons, Photic Stimulation, Visual Cortex, Rats, Sprague-Dawley, Anesthetics, Inhalation, Principal Component Analysis, Rats

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Desflurane selectively suppresses long-latency cortical neuronal response to flash in the rat

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