Repeated spontaneous pregnancies in 45 X Turner syndrome
Abstract
In Brief BACKGROUND: Spontaneous pregnancy rarely occurs in women with Turner syndrome, and poor maternal outcomes are prominent in these women. CASES: We report two women with 45,X Turner syndrome who had a total of four spontaneous pregnancies. Maternal and fetal outcomes were good despite maternal comorbidities. Cesarean deliveries were performed in two of the pregnancies because of aortic dilatation and fetopelvic disproportion. Both cases were initially diagnosed as primary amenorrhea (absent pubarche and menarche with serological hypogonadism). CONCLUSION: Repeated spontaneous pregnancies occur in women with 45,X Turner syndrome. Poor maternal outcome is not the rule. Repeated spontaneous pregnancies with good maternal and fetal outcomes may occur in women with amenorrheal hypogonadal 45,X Turner syndrome.
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Accurate characterization of even low-level chromosomal mosaicism by assessing two cell lines (lymphocytes and buccal cells) may help to more precisely estimate fertility potential.
“Accurate characterization of even low-level chromosomal mosaicism by assessing two cell lines (lymphocytes and buccal cells) may help to more precisely estimate fertility potential.573-578”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [577]
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- Authors
- Mortensen, K. H., Rohde, M. D., Uldbjerg, N., & Gravholt, C. H.
- Affiliations
- Aarhus University Hospital (DK)
- Venue
- Obstetrics & Gynecology
- Published
- 2010-02
- Volume
- 115
- Issue
- 2
- Pages
- 446-449
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2063826445
- Cited by
- 52
- References
- 9
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
- Keywords
- Turner syndrome, spontaneous conception, recurrent pregnancy, maternal outcomes, fetal outcomes, aortic dilatation, cesarean section, primary amenorrhea, hypogonadism
- MeSH terms
- Adult, Female, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Outcome, Turner Syndrome, Primary Ovarian Insufficiency, Young Adult
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