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Cited by 697

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Sarcopenia in older adults

Open access
Walston, Jeremy D.·2012·Current Opinion in Rheumatology
DOI 10.1097/bor.0b013e328358d59b
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Abstract

PURPOSE OF REVIEW: Sarcopenia, or the decline of skeletal muscle tissue with age, is one of the most important causes of functional decline and loss of independence in older adults. The purpose of this article is to review the current definitions of sarcopenia, its potential causes and clinical consequences, and the potential for intervention. RECENT FINDINGS: Although no consensus diagnosis has been reached, sarcopenia is increasingly defined by both loss of muscle mass and loss of muscle function or strength. Its cause is widely regarded as multifactorial, with neurological decline, hormonal changes, inflammatory pathway activation, declines in activity, chronic illness, fatty infiltration, and poor nutrition, all shown to be contributing factors. Recent molecular findings related to apoptosis, mitochondrial decline, and the angiotensin system in skeletal muscle have highlighted biological mechanisms that may be contributory. Interventions in general continue to target nutrition and exercise. SUMMARY: Efforts to develop a consensus definition are ongoing and will greatly facilitate the development and testing of novel interventions for sarcopenia. Although pharmaceutical agents targeting multiple biological pathways are being developed, adequate nutrition and targeted exercise remain the gold standard for therapy.

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Citations

Cites

Research works printed but not linked: 25

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Metadata

Authors
Walston, J. D.
Venue
Current Opinion in Rheumatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-11
Volume
24
Issue
6
Pages
623-627
ISSN
1040-8711 (ISSN-L)
DOI
10.1097/bor.0b013e328358d59b
OpenAlex
W1999765859
Cited by
697
References
10
FWCI
10.38
Type
journal article
Language
en
Open access
green

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