Sarcopenia with limited mobility: an international consensus
Open accessAbstract
A consensus conference convened by the Society of Sarcopenia, Cachexia and Wasting Disorders has concluded that "Sarcopenia, ie, reduced muscle mass, with limited mobility" should be considered an important clinical entity and that most older persons should be screened for this condition. "Sarcopenia with limited mobility" is defined as a person with muscle loss whose walking speed is equal to or less than 1 m/s or who walks less than 400 m during a 6-minute walk, and who has a lean appendicular mass corrected for height squared of 2 standard deviations or more below the mean of healthy persons between 20 and 30 years of age of the same ethnic group. The limitation in mobility should not clearly be a result of otherwise defined specific diseases of muscle, peripheral vascular disease with intermittent claudication, central and peripheral nervous system disorders, or cachexia. Clinically significant interventions are defined as an increase in the 6-minute walk of at least 50 meters or an increase of walking speed of at least 0.1 m/s.
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Aging coupled with a sedentary lifestyle contributes to progressive reductions in skeletal muscle mass, strength, and quality.
“Aging coupled with a sedentary lifestyle contributes to a progressive reduction in skeletal muscle health characterized by declines in skeletal muscle mass, strength, and quality (1, 2).”
From Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age (2015) · cites this paper as [2]
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- Authors
- Morley, J. E., Abbatecola, A. M., Argiles, J. M., Baracos, V., Bauer, J., Bhasin, S., Cederholm, T., Stewart Coats, A. J., Cummings, S. R., Evans, W. J., Fearon, K., Ferrucci, L., Fielding, R. A., Guralnik, J. M., Harris, T. B., Inui, A., Kalantar-Zadeh, K., Kirwan, B.-A., Mantovani, G., Muscaritoli, M., Newman, A. B., Rossi-Fanelli, F., Rosano, G. M. C., Roubenoff, R., Schambelan, M., Sokol, G. H., Storer, T. W., Vellas, B., von Haehling, S., Yeh, S.-S., & Anker, S. D.
- Affiliations
- St. Louis VA Medical Center (US)
- Boston University (US)
- Kagoshima University (JP)
- ORCID
- Morley, John E.
- Abbatecola, Angela Marie
- Baracos, Vickie
- Bhasin, Shalender
- Cederholm, Tommy
- Cummings, Steven R.
- Evans, William J.
- Ferrucci, Luigi
- Fielding, Roger A.
- Guralnik, Jack M.
- Harris, Tamara B.
- Inui, Akio
- Kirwan, Bridget-Anne
- Newman, Anne B.
- Rosano, Giuseppe M.C.
- Roubenoff, Ronenn
- Storer, Thomas W.
- Vellas, Bruno
- Anker, Stefan D.
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 12
- Issue
- 6
- Pages
- 403-409
- ISSN
- 1525-8610 (ISSN-L)
- PMC
- PMC5100674
- OpenAlex
- W2048798480
- Cited by
- 1,125
- References
- 101
- Citations by year
- 2026: 35 · 2025: 62 · 2024: 71 · 2023: 113 · 2022: 90 · 2021: 88 · 2020: 89 · 2019: 62 · 2018: 97 · 2017: 101 · 2016: 61 · 2015: 70 · 2014: 73 · 2013: 51 · 2012: 55
- FWCI
- 40.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Medical Directors Association (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (Z01AG000015)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, limited mobility, muscle mass loss, walking speed, 6-minute walk test, older adults, screening, clinical definition, intervention outcomes, cachexia
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Muscle, Skeletal, Internationality, Mobility Limitation, Sarcopenia
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