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Cited by 157Intensive Care Unit Cognitive DisordersRespiratory Support and MechanismsCOVID-19 and Mental Health

Psychiatric Symptoms in Acute Respiratory Distress Syndrome Survivors: A 1-Year National Multicenter Study

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Huang, Minxuan, Parker, Ann M., Bienvenu, O. Joseph, Dinglas, Victor D., Colantuoni, Elizabeth, Hopkins, Ramona O., Needham, Dale M.·2016·Critical Care Medicine
DOI 10.1097/ccm.0000000000001621PMC PMC4833555
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Abstract

OBJECTIVE: To evaluate prevalence, severity, and co-occurrence of and risk factors for depression, anxiety, and posttraumatic stress disorder symptoms over the first year after acute respiratory distress syndrome. DESIGN: Prospective longitudinal cohort study. SETTINGS: Forty-one Acute Respiratory Distress Syndrome Network hospitals across the United States. PATIENTS: Six hundred ninety-eight acute respiratory distress syndrome survivors. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Psychiatric symptoms were evaluated by using the Hospital Anxiety and Depression Scale and Impact of Event Scale-Revised at 6 and 12 months. Adjusted prevalence ratios for substantial symptoms (binary outcome) and severity scores were calculated by using Poisson and linear regression, respectively. During 12 months, a total of 416 of 629 patients (66%) with at least one psychiatric outcome measure had substantial symptoms in at least one domain. There was a high and almost identical prevalence of substantial symptoms (36%, 42%, and 24% for depression, anxiety, and posttraumatic stress disorder) at 6 and 12 months. The most common pattern of co-occurrence was having symptoms of all three psychiatric domains simultaneously. Younger age, female sex, unemployment, alcohol misuse, and greater opioid use in the ICU were significantly associated with psychiatric symptoms, whereas greater severity of illness and ICU length of stay were not associated. CONCLUSIONS: Psychiatric symptoms occurred in two thirds of acute respiratory distress syndrome survivors with frequent co-occurrence. Sociodemographic characteristics and in-ICU opioid administration, rather than traditional measures of critical illness severity, should be considered in identifying the patients at highest risk for psychiatric symptoms during recovery. Given high co-occurrence, acute respiratory distress syndrome survivors should be simultaneously evaluated for a full spectrum of psychiatric sequelae to maximize recovery.

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  • As many as 66% of acute respiratory distress syndrome survivors report clinically important depression, anxiety, and PTSD symptoms at 1 year post-discharge.

    “As many as 66% of acute respiratory distress syndrome (ARDS) survivors report clinically important symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD) at 1 year post-discharge.5–8”

    From Effects of mindfulness training programmes delivered by a self-directed mobile app and by telephone compared with an education programme for survivors of critical illness: A pilot randomised clinical trial (2019) · cites this paper as [5]

    The Results (Individual Psychiatric Domains and their Co-occurrence) report that 416 of 629 survivors (66%) had substantial symptoms in at least one of the three domains during one-year follow-up, not specifically at the 12-month assessment. The same section reports 53% with symptoms in at least one domain at six months and says results were similar at 12 months. Thus the source supports the symptom types and 66% figure, but not the claim's single-time-point framing. (LLM, conf=0.90)

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Research works printed but not linked: 2

  1. [14]Babor T Higgins-Biddle J Saunders J Monteiro M AUDIT: The Alcohol Use Disorder Identification Test: Guidelines for Use in Primary Care 2001
  2. [17]Weiss DS The Impact of Event Scale – Revised Wilson JP Keane TM Assessing Psychological Trauma and PTSD: A Practitioner’s Handbook Second New York Guilford Press 2004 168 89

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Authors
Huang, M., Parker, A. M., Bienvenu, O. J., Dinglas, V. D., Colantuoni, E., Hopkins, R. O., & Needham, D. M.
Affiliations
  • Brigham Young University (US)
  • National Heart, Lung, and Blood Institute (US)
ORCID
Venue
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-05
Volume
44
Issue
5
Pages
954-965
ISSN
0090-3493 (ISSN-L)
DOI
10.1097/ccm.0000000000001621
PMC
PMC4833555
OpenAlex
W2314180516
Cited by
157
References
49
Citations by year
2026: 8 · 2025: 10 · 2024: 23 · 2023: 13 · 2022: 15 · 2021: 18 · 2020: 12 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 9
FWCI
17.59
Type
journal article
Language
en
Open access
Locations
  • Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hr56170-19-0-1)
  • U.S. Public Health Service (HHSN 268200536179C, HHSN268200536165C, HHSN268200536175C)
  • National Heart, Lung, and Blood Institute (N01 HR056170, 5T32HL00753432, T32HL007534, R01HL091760)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Keywords
acute respiratory distress syndrome, depression, anxiety, post-traumatic stress disorder, risk factors, alcohol abuse, unemployment, sociodemographic factors, critical illness severity, ICU length of stay, long-term recovery
MeSH terms
Adult, Age Factors, Aged, Analgesics, Opioid, Anxiety, Depression, Female, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Quality of Life, Respiratory Distress Syndrome, Risk Factors, Severity of Illness Index, Sex Factors, Socioeconomic Factors, Stress Disorders, Post-Traumatic

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