The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*
Abstract
BACKGROUND: Patients with sepsis syndrome commonly have low serum selenium levels. Several randomized controlled trials have examined the efficacy of selenium supplementation on mortality in patients with sepsis. OBJECTIVE: To determine the efficacy and safety of high-dose selenium supplementation compared to placebo for the reduction of mortality in patients with sepsis. SOURCES OF DATA: We searched Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, SciFinder, and Clinicaltrials.gov. SELECTION CRITERIA: Randomized controlled parallel group trials comparing selenium supplementation in doses greater than daily requirement to placebo on the outcome of mortality in patients with sepsis syndrome. DATA COLLECTION AND ANALYSIS: Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. The primary outcome was mortality; secondary outcomes were ICU length of stay, nosocomial pneumonia, and adverse events. Trial authors were contacted for additional or clarifying information. RESULTS: Nine trials enrolling a total of 792 patients were included. Selenium supplementation in comparison to placebo was associated with lower mortality (odds ratio, 0.73; 95% CI, 0.54, 0.98; p = 0.03; I = 0%). Among patients receiving and not receiving selenium, there was no difference in ICU length of stay (mean difference, 2.03; 95% CI, -0.51, 4.56; p = 0.12; I = 0%) or nosocomial pneumonia (odds ratio, 0.83; 95% CI, 0.28, 2.49; p = 0.74; I = 56%). Significant heterogeneity among trials in adverse event reporting precluded pooling of results. CONCLUSIONS: In patients with sepsis, selenium supplementation at doses higher than daily requirement may reduce mortality. We observed no impact of selenium on ICU length of stay or risk of nosocomial pneumonia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Three meta-analyses showed a beneficial effect of selenium supplementation on mortality in septic patients.
“Three meta-analyses showed a beneficial effect of selenium supplementation on mortality in septic patients [72,73,74].”
From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [72]
Analysis of 15 RCTs showed a significant reduction of infectious complications and mortality with provision of a combination of antioxidant micronutrients.
“On the basis of the analysis of 15 RCTs (286), showing a significant reduction of infectious complications and of mortality, the 2016 ASPEN guidelines (43) recommend the provision of a combination of antioxidant micronutrients”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [286]
Critically ill patients exhibit low circulating ascorbic acid concentrations.
“Ascorbic acid (vitamin C): Critically ill patients exhibit low circulating ascorbic acid concentrations (286).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [286]
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · see citing works
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163 · see citing works
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563 · see citing works
Burk, R. F., & Hill, K. (2005) · Annual review of nutrition · doi:10.1146/annurev.nutr.24.012003.132120 · Cited by 591 · see citing works
Selenium, the Thyroid, and the Endocrine System
Köhrle, J., Jakob, F. J., Contempré, B., & Dumont, J. E. (2005) · Endocrine Reviews · doi:10.1210/er.2001-0034 · Cited by 527 · see citing works
Protection against reactive oxygen species by selenoproteins
Steinbrenner, H., & Sies, H. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.014 · Cited by 513 · see citing works
Angstwurm, M., Engelmann, L., Zimmermann, T. P., Lehmann, C., Spes, C. H., Abel, P., Strauß, R., Meier‐Hellmann, A., Insel, R., Radke, J., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000251124.83436.0e · Cited by 503 · see citing works
Trends in selenium biochemistry
Birringer, M., Pilawa, S., & Flohé, L. (2002) · Natural Product Reports · doi:10.1039/b205802m · Cited by 441 · see citing works
Heyland, D., Dhaliwal, R., Suchner, U., & Berger, M. (2005) · Intensive Care Medicine · doi:10.1007/s00134-004-2522-z · Cited by 420 · see citing works
Andrews, P. J. D., Avenell, A., Noble, D. W., Campbell, M. K., Croal, B. L., Simpson, W. G., Vale, L. D., Battison, C. G., Jenkinson, D. J., Cook, J. A., et al. (2011) · BMJ · doi:10.1136/bmj.d1542 · Cited by 379 · see citing works
Self-citationSelenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients
Forceville, X., Vitoux, D., Gauzit, R., Combes, A., Lahilaire, P., & Chappuis, P. (1998) · Critical Care Medicine · doi:10.1097/00003246-199809000-00021 · Cited by 338 · see citing works
Selenoprotein Metabolism and Function: Evidence for More than One Function for Selenoprotein P
Burk, R. F., Hill, K. E., & Motley, A. K. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1517s · Cited by 287 · see citing works
Angstwurm, M., Schottdorf, J., Schopohl, J., & Gaertner, R. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00017 · Cited by 252 · see citing works
Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis
Manzanares, W., Dhaliwal, R., Jiang, X., Murch, L., & Heyland, D. K. (2012) · Critical Care · doi:10.1186/cc11316 · Cited by 234 · see citing works
Self-citationSelenium and selenoproteins in mammals: extraordinary, essential, enigmatic
Schomburg, L., Schweizer, U., & Köhrle, J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4114-z · Cited by 202 · see citing works
Forceville, X., Laviolle, B., Annane, D., Vitoux, D., Bleichner, G., Korach, J., Cantais, E., Georges, H., Soubirou, J.-L., Combes, A., et al. (2007) · Critical Care · doi:10.1186/cc5960 · Cited by 193 · see citing works
Sakr, Y. L., Reinhart, K., Bloos, F., Marx, G., Rußwurm, S., Bauer, M. W., & Brunkhorst, F. M. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem091 · Cited by 173 · see citing works
Self-citationHigh-dose selenium substitution in sepsis: a prospective randomized clinical trial
Valenta, J., Brodská, H., Drabek, T., Hendl, J., & Kazda, A. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2153-0 · Cited by 139 · see citing works
Effect of selenium supplementation on biochemical markers and outcome in critically ill patients
Mishra, V., Baines, M., Perry, S. E., McLaughlin, P. J., Carson, J., Wenstone, R., & Shenkin, A. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.10.003 · Cited by 134 · see citing works
Selenium supplementation for critically ill adults.
Avenell, A., Noble, D., Barr, J., & Engelhardt, T. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003703.pub2 · Cited by 123 · see citing works
Manzanares, W., Biestro, A., Torre, M., Galusso, F., Facchin, G., & Hardy, G. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2212-6 · Cited by 109 · see citing works
Self-citationMode of Action of Endotoxin: Role of Free Radicals and Antioxidants
Bhattacharyya, J., Biswas, S., & Datta, A. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043456098 · Cited by 109 · see citing works
Stoppe, C., Schälte, G., Rossaint, R., Coburn, M., Graf, B., Spillner, J., Marx, G., & Rex, S. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182190d48 · Cited by 85 · see citing works
Critically elucidating the role of selenium
Vincent, J., & Forceville, X. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3282f49afe · Cited by 84 · see citing works
The facts and controversies about selenium.
Dodig, S., & Čepelak, I. (2004) · PubMed · Cited by 64 · see citing works
The facts and controverses about selenium
Dodig, S., & Čepelak, I. (2004) · University of Zagreb University Computing Centre (SRCE) · Cited by 62 · see citing works
Practicalities of selenium supplementation in critically ill patients
Angstwurm, M. W., & Gaertner, R. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000222105.30795.7f · Cited by 55 · see citing works
Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?
Heyland, D. K. (2007) · Critical Care · doi:10.1186/cc5975 · Cited by 53 · see citing works
[Selenium administration in patients with sepsis syndrome. A prospective randomized study].
Zimmermann, T., Albrecht, S., Kühne, H., Vogelsang, U., Grützmann, R., & Kopprasch, S. (1997) · Medizinische Klinik · doi:10.1007/bf03041947 · Cited by 52 · see citing works
Seleno-enzymes and seleno-compounds: the two faces of selenium.
Forceville, X. (2006) · Critical Care · doi:10.1186/cc5109 · Cited by 48 · see citing works
Hardy, G., & Hardy, I. J. (2004) · Nutrition · doi:10.1016/j.nut.2004.03.014 · Cited by 39 · see citing works
Does early administration of selenium improve neurological outcome after cardiac arrest?
Reisinger, J., Höllinger, K., Lang, W., Steiner, C., Winter, T. C., Winter, A., Mori, M., Lindorfer, A., Kiblböck, D., & Siostrzonek, P. (2009) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2008.01.020 · Cited by 21 · see citing works
[Septic shock and selenium administration].
Forceville, X., Aouizerate, P., & Guizard, M. (2001) · PubMed · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Self-citationSurviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652 · see citing works
Self-citationESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
Self-citationRegulation of Selenium Metabolism and Transport
Burk, R. F., & Hill, K. E. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034250 · Cited by 662 · see citing works
Duntas, L., & Benvenga, S. (2015) · Endocrine · doi:10.1007/s12020-014-0477-6 · Cited by 379 · see citing works
Nutrition in the acute phase of critical illness
Casaer, M. P., & Van den Berghe, G. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1304623 · Cited by 335 · see citing works
Bloos, F., Trips, E., Nierhaus, A., Briegel, J., Heyland, D. K., Jaschinski, U., Moerer, O., Weyland, A., Marx, G., Gründling, M., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.2514 · Cited by 268 · see citing works
Self-citationToxicology and pharmacology of synthetic organoselenium compounds: an update
Nogueira, C. W., Barbosa, N. V., & da Rocha, J. B. T. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03003-5 · Cited by 242 · see citing works
Antioxidant Vitamins and Trace Elements in Critical Illness
Koekkoek, W. A. C. (., & van Zanten, A. R. H. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616653832 · Cited by 203 · see citing works
Selenium and Human Health: Witnessing a Copernican Revolution?
Jabłońska, E., & Vinceti, M. (2015) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2015.1055163 · Cited by 149 · see citing works
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147 · see citing works
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.05.002 · Cited by 150 · see citing works
Nutrition in Sepsis: A Bench-to-Bedside Review.
De Waele, E., Malbrain, M. L. N. G., & Spapen, H. (2020) · Nutrients · doi:10.3390/nu12020395 · Cited by 140 · see citing works
Role of divalent metals in infectious disease susceptibility and outcome
Weiss, G., & Carver, P. L. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.01.018 · Cited by 123 · see citing works
Wischmeyer, P. E. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2017.08.008 · Cited by 111 · see citing works
Manzanares, W., Lemieux, M., Elke, G., Langlois, P. L., Bloos, F., & Heyland, D. K. (2016) · Critical Care · doi:10.1186/s13054-016-1529-5 · Cited by 100 · see citing works
“Conversely to previous findings regarding IV high-dose Se monotherapy [8, 9], we did not find an overall effect of Se on infectious complications in the critically ill, although parenteral Se without an initial bolus significantly reduced infections.”
ResultSelf-citationMetabolic resuscitation in sepsis: a necessary step beyond the hemodynamic?
Leite, H. P., & de Lima, L. F. P. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.05.37 · Cited by 82 · see citing works
Selenium supplementation in critically ill patients: A systematic review and meta-analysis
Landucci, F., Mancinelli, P., De Gaudio, A. R., & Virgili, G. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.08.017 · Cited by 76 · see citing works
DGEM-Leitlinie: „Klinische Ernährung in der Intensivmedizin“
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2018) · Aktuelle Ernährungsmedizin · doi:10.1055/a-0713-8179 · Cited by 76 · see citing works
Trace Elements in Parenteral Nutrition: Considerations for the Prescribing Clinician
Jin, J., Mulesa, L., & Rouillet, M. C. (2017) · Nutrients · doi:10.3390/nu9050440 · Cited by 70 · see citing works
Micronutrient Deficiencies in Medical and Surgical Inpatients
Berger, M. M., Pantet, O., Schneider, A. G., & Ben‐Hamouda, N. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8070931 · Cited by 70 · see citing works
The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin
Ghashut, R. A., McMillan, D. C., Kinsella, J., Vasilaki, A. T., Talwar, D. K., & Duncan, A. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.02.010 · Cited by 68 · see citing works
Parenteral trace element provision: recent clinical research and practical conclusions
Stehle, P., Stoffel‐Wagner, B., & Kuhn, K. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.53 · Cited by 54 · see citing works
Kagan, I., Cohen, J. D., Stein, M., Bendavid, I., Pinsker, D., Silva, V., Theilla, M., Anbar, R., Lev, S., Grinev, M., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3646-z · Cited by 52 · see citing works
Chelkeba, L., Ahmadi, A., Abdollahi, M., Najafi, A., Ghadimi, M. H., Mosaed, R., & Mojtahedzadeh, M. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0071-y · Cited by 51 · see citing works
Peterman, E., Sullivan, C., Goody, M. F., Rodríguez-Nunez, I., Yoder, J. A., & Kim, C. H. (2014) · Infection and Immunity · doi:10.1128/iai.02245-14 · Cited by 51 · see citing works
Selenium in Human Health and Disease: An Overview
Brigelius‐Flohé, R. (2018) · Molecular and integrative toxicology · doi:10.1007/978-3-319-95390-8_1 · Cited by 51 · see citing works
Iglesias, S., Leite, H. P., Paes, Â. T., de Oliveira, S., & Sarni, R. O. S. (2014) · Critical Care · doi:10.1186/cc13877 · Cited by 48 · see citing works
Emerging Therapeutic Targets of Sepsis-Associated Acute Kidney Injury
Swaminathan, S., Rosner, M. H., & Okusa, M. D. (2015) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2015.01.005 · Cited by 45 · see citing works
Schmidt, T., Pargger, H., Seeberger, E. E., Eckhart, F., von Felten, S., & Haberthür, C. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.04.019 · Cited by 41 · see citing works
Increased plasma selenium is associated with better outcomes in children with systemic inflammation
Leite, H. P., Nogueira, P. C. K., Iglesias, S., de Oliveira, S. V., & Sarni, R. O. S. (2014) · Nutrition · doi:10.1016/j.nut.2014.09.008 · Cited by 40 · see citing works
Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes
Lopes, E., Leite, H. P., & Konstantyner, T. (2019) · Translational research · doi:10.1016/j.trsl.2019.01.004 · Cited by 39 · see citing works
Pharmaconutrition With Selenium in Critically Ill Patients
Manzanares, W., Langlois, P. L., & Heyland, D. K. (2014) · Nutrition in Clinical Practice · doi:10.1177/0884533614561794 · Cited by 38 · see citing works
Self-citationThe truth about nutrition in the ICU
Singer, P., Doig, G. S., & Pichard, C. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-3162-y · Cited by 38 · see citing works
Fink, K., Moebes, M., Vetter, C., Bourgeois, N., Schmid, B., Bode, C., Helbing, T., & Busch, H.-J. (2015) · Critical Care · doi:10.1186/s13054-015-0774-3 · Cited by 34 · see citing works
Update on antioxidant micronutrients in the critically ill
Manzanares, W., Langlois, P. L., & Hardy, G. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32836599e5 · Cited by 35 · see citing works
Self-citationGolin, A., Tinkov, A. A., Aschner, M., Farina, M., & da Rocha, J. B. T. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127099 · Cited by 35 · see citing works
Stoppe, C., McDonald, B., Rex, S., Manzanares, W., Whitlock, R., Fremes, S., Fowler, R., Lamarche, Y., Meybohm, P., Haberthür, C., et al. (2014) · Trials · doi:10.1186/1745-6215-15-339 · Cited by 31 · see citing works
Self-citationSerum selenium and zinc levels in critically ill surgical patients
Jang, J. Y., Shim, H., Lee, S. H., & Lee, J. G. (2013) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.12.003 · Cited by 34 · see citing works
Costa, N., Gut, A., Pimentel, J. A. C., Cozzolino, S., Azevedo, P., Fernandes, A., Polegato, B., Tanni, S., Gaiolla, R., Zornoff, L., et al. (2014) · Critical Care · doi:10.1186/cc13860 · Cited by 26 · see citing works
Ling, L., Zhang, S., Zhi, L.-D., Li, H., Wen, Q.-K., Li, G., & Zhang, W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.042 · Cited by 31 · see citing works
Retractedvan Zanten, A. R. H. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000152 · Cited by 31 · see citing works
Laurent, M., Bastuji‐Garin, S., Plonquet, A., Bories, P.-N., Thuaut, A. L., Audureau, É., Lang, P.-O., Nakib, S., Liuu, É., Canouï‐Poitrine, F., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.01.012 · Cited by 31 · see citing works
Kim, Y., Kim, D. C., Cho, E., Ko, S., Kwon, W., Suh, G., & Shin, H.-K. (2014) · Journal of Inflammation · doi:10.1186/s12950-014-0036-1 · Cited by 28 · see citing works
Aisa-Álvarez, A., Pérez-Torres, I., Guarner‐Lans, V., Manzano-Pech, L., Cruz-Soto, R., Márquez-Velasco, R., Cásarez-Alvarado, S., Franco-Granillo, J., Núñez-Martínez, M. E., & Soto, M. E. (2023) · Cells · doi:10.3390/cells12091330 · Cited by 28 · see citing works
Sherlock, L. G., Sjostrom, K., Lei, S., Delaney, C. A., Tipple, T. E., Krebs, N. F., Nozik‐Grayck, E., & Wright, C. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.595282 · Cited by 27 · see citing works
Brodska, H. L., Valenta, J., Malíčková, K., Kohout, P., Kazda, A., & Drábek, T. (2015) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2015.02.005 · Cited by 27 · see citing works
Kwon, W., Suh, G., Kim, K. S., Jung, Y., Kim, S. H., Kim, J. S., & You, K. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001422 · Cited by 21 · see citing works
Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis
Reitsema, V. A., Star, B. S., de Jager, V. D., van Meurs, M., Henning, R. H., & Bouma, H. R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7537 · Cited by 27 · see citing works
The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome
Forceville, X. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31829106e5 · Cited by 26 · see citing works
Woth, G., Nagy, B., Mérei, Á., Ernyey, B., Vincze, R., Kaurics, Z., Lantos, J., Bogár, L., & Mühl, D. (2014) · Journal of critical care · doi:10.1016/j.jcrc.2014.04.010 · Cited by 23 · see citing works
Plasma glutathione reductase activity and prognosis of septic shock.
Kim, J. S., Kwon, W., Suh, G., Kim, K. S., Jung, Y., Kim, S. H., & Lee, S. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2015.07.044 · Cited by 20 · see citing works
Emerging therapies for the treatment of sepsis
Vincent, J. (2015) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000210 · Cited by 23 · see citing works
Redox-Active Selenium in Health and Disease: A Conceptual Review
Lipiński, B. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557517666161104125022 · Cited by 22 · see citing works
Manzanares, W., Moreira, E., & Hardy, G. (2020) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2020.110989 · Cited by 20 · see citing works
Self-citationLin, Y., Alhaskawi, A., Chen, L., & Moqbel, S. A. A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1695992 · Cited by 21 · see citing works
Zakharova, V., Pletjushkina, O. Y., Zinovkin, R. A., Popova, E. N., & Chernyak, B. V. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25626 · Cited by 20 · see citing works
Freitas, R. G. B. D. O. N., Nogueira, R. J. N., Cozzolino, S., Vasques, A., & Hessel, G. (2017) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2017.03.007 · Cited by 18 · see citing works
Selenium status in neonates with connatal infection
Wiehe, L., Cremer, M., Wisniewska, M. J., Becker, N., Rijntjes, E., Martitz, J., Hybsier, S., Renko, K., Bührer, C., & Schomburg, L. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002208 · Cited by 19 · see citing works
Jaff, S., Zeraattalab-Motlagh, S., Khosroshahi, R. A., Gubari, M. I. M., Mohammadi, H., & Djafarian, K. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01075-w · Cited by 16 · see citing works
Uzzan, M., Kirchgesner, J., Poupon, J., Corcos, O., Pingenot, I., & Joly, F. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.05.008 · Cited by 17 · see citing works
Serum selenium in critically ill patients: Profile and supplementation in a depleted region
Broman, L., Bernardson, A., Bursell, K., Wernerman, J., Fläring, U., & Tjäder, I. (2020) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13573 · Cited by 11 · see citing works
Safabakhsh, M., Imani, H., Shahinfar, H., Mohammadpour, M., Rohani, P., & Shab‐Bidar, S. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.03.030 · Cited by 18 · see citing works
Supplementation with selenium and coenzyme Q10 in critically ill patients.
Hargreaves, I. P., & Mantle, D. (2019) · British journal of hospital medicine · doi:10.12968/hmed.2019.80.10.589 · Cited by 14 · see citing works
Kong, L., Wu, Q. F., & Liu, B. (2021) · African Health Sciences · doi:10.4314/ahs.v21i1.36 · Cited by 15 · see citing works
Mousavi, M., Saghaleini, S., Mahmoodpoor, A., Ghojazadeh, M., & Mousavi, S. N. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.11.026 · Cited by 9 · see citing works
Forceville, X., Antwerpen, P. V., Annane, D., & Vincent, J. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8062 · Cited by 13 · see citing works
Forceville, X., Touati, S., Toumelin, P. L., Ducros, V., Laporte, F., Chancerelle, Y., & Agay, D. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.03.010 · Cited by 12 · see citing works
Major publications in the critical care pharmacotherapy literature: January–December 2013
Rech, M. A., Day, S. A., Kast, J. M., Donahey, E. E., Pajoumand, M., Kram, S. J., Erdman, M. J., Peitz, G. J., Allen, J. M., Palmer, A. E., et al. (2015) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp140241 · Cited by 10 · see citing works
Selenium pharmaconutrition in sepsis: to give or not to give? Is this still the question?
Manzanares, W., Langlois, P., & Hardy, G. (2013) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2013.05.010 · Cited by 9 · see citing works
Self-citationSerum trace elements levels in patients transferred from the intensive care unit to wards
Gündoğan, K., Günay, Y., Özer, N. T., Şahin, G. G., Mendil, N. Ö. A., Şahin, S., Temel, Ş., Güven, M., & Sungur, M. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.06.014 · Cited by 8 · see citing works
Pharmaconutrition with intravenous selenium in intensive care: The end of an era?
Langlois, P., Hardy, G., & Manzanares, W. (2018) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2017.07.018 · Cited by 7 · see citing works
Self-citationForceville, X., Laviolle, B., Gromadzińska, J., Boutten, A., Antwerpen, P. V., Plouvier, E., Annane, D., & Bellissant, É. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127031 · Cited by 7 · see citing works
Castel, T., Theron, M., Pichavant-Rafini, K., Guernec, A., Joublin-Delavat, A., Gueguen, B., & Léon, K. (2021) · Physiological Reports · doi:10.14814/phy2.14933 · Cited by 4 · see citing works
Prednisolone but not selenium and rtPA reduces edema and improves angiogenesis after burn in mice
Goertz, O., Over, H., von der Lohe, L., Lauer, H., Ring, A., Daigeler, A., Lehnhardt, M., & Kolbenschlag, J. (2016) · Burns · doi:10.1016/j.burns.2015.08.008 · Cited by 6 · see citing works
Erythrocyte and plasma selenium in children with acute inflammatory response.
de Almeida, C. B., Leite, H., Lopes, E., Konstantyner, T., & Franco, M. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127068 · Cited by 7 · see citing works
Drug-Induced “Suspended Animation”
Asfar, P., & Radermacher, P. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000985 · Cited by 5 · see citing works
Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
Liu, Y., Zhao, X., Xu, Z., Li, Z., & Wang, Y.-C. (2025) · Open Medicine · doi:10.1515/med-2025-1296 · Cited by 4 · see citing works
Berger, M. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27687-8_10 · Cited by 3 · see citing works
Impact of selenium status and supplementation on outcomes in critically ill patients
Tan, H.-H., Liang, Y.-C., Shao, Y.-C., Chen, C.-M., & Chou, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-19315-w · Cited by 6 · see citing works
Nutritional Therapy Related Complications in Hospitalized Adult Patients: A Korean Multicenter Trial
Seol, E., Kwon, K. S., Kim, J. G., Kim∥, J. T., Kim, J., Moon, S. M., Park, D. J., Park, J. H., Park, J. H., Park, J. Y., et al. (2019) · Journal of Clinical Nutrition · doi:10.15747/jcn.2019.11.1.12 · Cited by 3 · see citing works
Koszta, G., & Fülesdi, B. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29727 · Cited by 4 · see citing works
Yogaratnam, D., Miller, M. A., Ross, B., & DiNapoli, M. A., Jr. (2014) · Critical Care Nursing Clinics of North America · doi:10.1016/j.ccell.2014.02.004 · Cited by 3 · see citing works
Radke, D. I., Bogatsch, H., Engel, C., Bloos, F., Meybohm, P., Bauer, M. W., Homayr, A. L., Stoppe, C., Elke, G., Lindner, M., et al. (2025) · Journal of Intensive Care · doi:10.1186/s40560-025-00790-2 · Cited by 2 · see citing works
Self-citationThe Treatment of Sepsis: From Failed Therapies to New Possibilities
Chung, H., Rochwerg, B. N., & Fox‐Robichaud, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801078-5.00017-0 · Cited by 2 · see citing works
Wiedermann, C. J. (2014) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-014-0379-7 · Cited by 2 · see citing works
8 – Medical, Nursing, and Cosmetic Procedures
Beaufrère, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-7234-3832-8.00008-0 · Cited by 1 · see citing works
Critical care medicine 2013: a review and prospect.
Huang, W. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.12.51 · Cited by 3 · see citing works
Correction of Selenium status as a tool for preventive medicine
Mazilina, A. N., Skalny, A. V., Rakitskii, V. N., Rusanov, A. S., Chernova, L. N., & Tinkov, A. A. (2021) · Health Care of the Russian Federation · doi:10.47470/0044-197x-2021-65-5-447-453 · Cited by 2 · see citing works
Pathophysiology of sepsis-associated AKI [SA-AKI]
Doradla, L. P. S., & Prasad, N. (2016) · Clinical Queries Nephrology · doi:10.1016/j.cqn.2016.04.005 · Cited by 1 · see citing works
Pharmaconutrition としての微量元素・ビタミン投与の是非
智, 村., 和彦, 深., & 安原, 洋. (2017) · The Japanese Journal of SURGICAL METABOLISM and NUTRITION · doi:10.11638/jssmn.51.6_339 · Cited by 1 · see citing works
Early recognition and treatment of severe sepsis and septic shock in CAP
Jaehne, A. K., Jayaprakash, N., Hurst, G., Moore, S. C., Harrison, M. F., & Rivers, E. P. (2014) · European Respiratory Society eBooks · doi:10.1183/1025448x.10004313 · Cited by 1 · see citing works
Langlois, P., Manzanares, W., & Hardy, G. (2013) · Réanimation · doi:10.1007/s13546-013-0717-4
Self-citationMicronutrient Supplementation for Critically Ill Adults: Practical Application
Visser, J., & Blaauw, R. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8503-2_78-1
Moore, L. J., & Moore, F. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1121-9_9
Huang, T., Shyu, Y., Yuan, S., & Chen, P. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182a12289
Farmaconutrición parenteral con selenio en la sepsis
Langlois, P. L., Figliolino, L. F. D. O., Hardy, G., & Manzanares, W. (2014) · Medicina Intensiva · doi:10.1016/j.medin.2013.07.007 · Cited by 1 · see citing works
Self-citationKagan, I., & Singer, P. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107323919.011
Ghashut, R. A. (2015) · Enlighten: Theses (The University of Glasgow)
Fuller, J., Granton, J. T., & McConachie, I. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107323919.002
- Authors
- Alhazzani, W., Jacobi, J., Sindi, A., Hartog, C., Reinhart, K., Kokkoris, S., Gerlach, H., Andrews, P., Drabek, T., Manzanares, W., Cook, D. J., & Jaeschke, R. Z.
- Affiliations
- McMaster University (CA)
- Methodist Hospital (US)
- Jena University Hospital (DE)
- Western General Hospital (GB)
- Vivantes Klinikum (DE)
- University of Edinburgh (GB)
- Universidad de la República de Uruguay (UY)
- ORCID
- Venue
- Critical Care Medicine
- Published
- 2013-06
- Volume
- 41
- Issue
- 6
- Pages
- 1555-1564
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2071813212
- Cited by
- 118
- References
- 35
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 14 · 2015: 17 · 2014: 21 · 2013: 13
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- selenium supplementation, sepsis, mortality, serum selenium, ICU length of stay, nosocomial pneumonia, adverse events, critically ill patients
- MeSH terms
- Antioxidants, Cross Infection, Humans, Intensive Care Units, Length of Stay, Pneumonia, Selenium, Randomized Controlled Trials as Topic, Systemic Inflammatory Response Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
