Depressive Symptoms and Clinical Status During the Treatment of Adolescent Suicide Attempters (TASA) Study
Open accessAbstract
Objective To examine the course of depression during the treatment of adolescents with depression who had recently attempted suicide.Method Adolescents (N = 124), ages 12 to 18 years, with a 90-day history of suicide attempt, a current diagnosis of depressive disorder (96.0% had major depressive disorder), and a Children's Depression Rating Scale-Revised (CDRS-R) score of 36 or higher, entered a 6-month treatment with antidepressant medication, cognitive-behavioral therapy focused on suicide prevention, or their combination (Comb), at five academic sites. Treatment assignment could be either random or chosen by study participants. Intent-to-treat, mixed effects regression models of depression and other relevant ratings were estimated. Improvement and remission rates were computed with the last observation carried forward.Results Most patients (n = 104 or 84%) chose treatment assignment, and overall, three fourths (n = 93) received Comb. In Comb, CDRS-R declined from a baseline adjusted mean of 49.6 (SD 12.3) to 38.3 (8.0) at week 12 and to 27.0 (10.1) at week 24 (p < .0001), with a Clinical Global Impression -defined improvement rate of 58.0% at week 12 and 72.2% at week 24 and a remission (CDRS-R ≤ 28) rate of 32.5% at week 12 and 50.0% at week 24. The CDRS-R and the Scale for Suicidal Ideation scores were correlated at baseline (r = 0.43, p < .0001) and declined in parallel.Conclusions When vigorously treated with a combination of medication and psychotherapy, adolescents with depression who have recently attempted suicide show rates of improvement and remission of depression that seem comparable to those observed in nonsuicidal adolescents with depression.
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- Authors
- Vitiello, B., Brent, D. A., Greenhill, L. L., Emslie, G., Wells, K., Walkup, J. T., Stanley, B., Bukstein, O., Kennard, B. D., Compton, S., Coffey, B., Cwik, M. F., Posner, K., Wagner, A., March, J. S., Riddle, M., Goldstein, T., Curry, J., Capasso, L., Mayes, T., Shen, S., Gugga, S. S., Turner, J. B., Barnett, S., & Zelazny, J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Vitiello, Benedetto
- ORCID
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 48
- Issue
- 10
- Pages
- 997-1004
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC2889199
- OpenAlex
- W2032874227
- Cited by
- 72
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Funders
- U.S. Department of Health and Human Services
- Eli Lilly and Company
- Pfizer
- Johns Hopkins University
- University of Pittsburgh
- Shire
- National Institutes of Health
- National Institute of Mental Health (MH66750, U10MH066762, U10MH066778, U10MH066750, MH66769, MH66762, MH66778, U10MH066775, U10MH066769, MH66775)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- adolescent depression, suicide attempters, major depressive disorder, antidepressants, cognitive behavioral therapy, suicide prevention, combination therapy, depression remission, suicidal ideation, Children's Depression Rating Scale-Revised
- MeSH terms
- Adolescent, Antidepressive Agents, Child, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Interview, Psychological, Male, Suicide, Attempted, Cognitive Behavioral Therapy, Dysthymic Disorder, Secondary Prevention
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