Cited by 262Suicide and Self-Harm StudiesPersonality Disorders and PsychopathologyHomicide, Infanticide, and Child Abuse

The Treatment of Adolescent Suicide Attempters Study (TASA): Predictors of Suicidal Events in an Open Treatment Trial

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Brent, David A., Greenhill, Laurence L., Compton, Scott, Emslie, Graham, Wells, Karen, Walkup, John T., Vitiello, Benedetto, Bukstein, Oscar +17 more·2009·Journal of the American Academy of Child & Adolescent Psychiatry

Abstract

Objective To identify the predictors of suicidal events and attempts in adolescent suicide attempters with depression treated in an open treatment trial.Method Adolescents who had made a recent suicide attempt and had unipolar depression (n =124) were either randomized (n = 22) or given a choice (n = 102) among three conditions. Two participants withdrew before treatment assignment. The remaining 124 youths received a specialized psychotherapy for suicide attempting adolescents (n = 17), a medication algorithm (n = 14), or the combination (n = 93). The participants were followed up 6 months after intake with respect to rate, timing, and predictors of a suicidal event (attempt or acute suicidal ideation necessitating emergency referral).Results The morbid risks of suicidal events and attempts on 6-month follow-up were 0.19 and 0.12, respectively, with a median time to event of 44 days. Higher self-rated depression, suicidal ideation, family income, greater number of previous suicide attempts, lower maximum lethality of previous attempt, history of sexual abuse, and lower family cohesion predicted the occurrence, and earlier time to event, with similar findings for the outcome of attempts. A slower decline in suicidal ideation was associated with the occurrence of a suicidal event.Conclusions In this open trial, the 6-month morbid risks for suicidal events and for reattempts were lower than those in other comparable samples, suggesting that this intervention should be studied further. Important treatment targets include suicidal ideation, family cohesion, and sequelae of previous abuse. Because 40% of events occurred with 4 weeks of intake, an emphasis on safety planning and increased therapeutic contact early in treatment may be warranted.

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Authors
Brent, D. A., Greenhill, L. L., Compton, S., Emslie, G., Wells, K., Walkup, J. T., Vitiello, B., Bukstein, O., Stanley, B., Posner, K., Kennard, B. D., Cwik, M. F., Wagner, A., Coffey, B., March, J. S., Riddle, M., Goldstein, T., Curry, J., Barnett, S., Capasso, L., Zelazny, J., Hughes, J., Shen, S., Gugga, S. S., & Turner, J. B.
Affiliations
Johns Hopkins University (US)
Corresponding author
Brent, David A.
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2009-10
Volume
48
Issue
10
Pages
987-996
ISSN
0890-8567 (ISSN-L)
OpenAlex
W1966467955
Cited by
262
References
39
Citations by year
2026: 8 · 2025: 8 · 2024: 15 · 2023: 11 · 2022: 12 · 2021: 23 · 2020: 15 · 2019: 21 · 2018: 21 · 2017: 12 · 2016: 12 · 2015: 14 · 2014: 25 · 2013: 18 · 2012: 19
FWCI
16.22
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
National Institute of Mental Health (MH66750, U10MH066762, U10MH066778, U10MH066750, MH66769, MH66762, MH66778, U10MH066775, U10MH066769, MH66775)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
Keywords
suicide attempts, suicidal ideation, adolescent depression, suicide prevention, medication algorithm, family cohesion, sexual abuse history, household income, safety planning, treatment goals
MeSH terms
Adolescent, Algorithms, Antidepressive Agents, Child, Combined Modality Therapy, Major Depressive Disorder, Female, Humans, Interview, Psychological, Male, Personality Inventory, Suicide, Attempted, Cognitive Behavioral Therapy, Dysthymic Disorder, Secondary Prevention

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