Cited by 159Advanced Causal Inference TechniquesStatistical Methods in EpidemiologyMeta-analysis and systematic reviews

Estimating Direct Effects in Cohort and Case–Control Studies

Vansteelandt, Stijn·2009·Epidemiology

Abstract

Estimating the effect of an exposure on an outcome, other than through some given mediator, requires adjustment for all risk factors of the mediator that are also associated with the outcome. When these risk factors are themselves affected by the exposure, then standard regression methods do not apply. In this article, I review methods for accommodating this and discuss their limitations for estimating the controlled direct effect (ie, the exposure effect when controlling the mediator at a specified level uniformly in the population). In addition, I propose a powerful and easy-to-apply alternative that uses G-estimation in structural nested models to address these limitations both for cohort and case-control studies.

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Crossref · 10.1097/ede.0b013e3181b6f4c9

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Authors
Vansteelandt, S.
Affiliations
Ghent University (BE)
Corresponding author
Vansteelandt, Stijn
Venue
Epidemiology
Published
2009-11
Volume
20
Issue
6
Pages
851-860
ISSN
1044-3983 (ISSN-L)
OpenAlex
W1971464691
Cited by
159
References
22
Citations by year
2025: 6 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 15 · 2015: 7 · 2014: 12 · 2013: 8 · 2012: 17
FWCI
10.17
Type
journal article
Language
en
Open access
closed
Locations
  • Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Keywords
controlled direct effect, G-estimation, cohort studies, case-control study
MeSH terms
Humans, Risk Factors, Models, Statistical, Cohort Studies, Epidemiologic Research Design, Causality, Confounding Factors, Epidemiologic, Outcome Assessment, Health Care

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