Nonpharmacologic intervention and prevention strategies for depression during pregnancy and the postpartum

DIMIDJIAN, SONA; GOODMAN, SHERRYL

doi:10.1097/grf.0b013e3181b52da6

Cited by 99Maternal Mental Health During Pregnancy and PostpartumPregnancy-related medical researchTreatment of Major Depression

Nonpharmacologic intervention and prevention strategies for depression during pregnancy and the postpartum

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DIMIDJIAN, SONA, GOODMAN, SHERRYL·2009·Clinical Obstetrics & Gynecology

DOI 10.1097/grf.0b013e3181b52da6PMC PMC5805470

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Abstract

Perinatal depression is a serious and disabling disorder that has enduring consequences for both women and their children. Although efficacious pharmacologic strategies are available, many perinatal women are reluctant to continue or start antidepressant medications because of the concern about impact on the fetus or, later, the nursing infant. Weighing the costs and benefits of pharmacologic strategies often requires complex-decision making on the part of obstetric providers and patients. Nonpharmacologic intervention and prevention strategies offer the potential of beneficial outcomes without substantial risk profiles. This paper reviews the evidence base for nonpharmacologic intervention and prevention strategies for depression during pregnancy and the postpartum. The evidence base suggests that efficacious nonpharmacologic options are available for women during pregnancy and postpartum; however, important research questions remain.

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Psychotherapeutic interventions such as interpersonal psychotherapy and cognitive behavioral therapy are effective in treating perinatal depression and anxiety.
“Psychotherapeutic interventions such as interpersonal psychotherapy and cognitive behavioral therapy (CBT), which have been shown to be effective in treating perinatal depression and anxiety (28, 29), are preferred (27, 30, 31).”
From Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study (2022) · cites this paper as [29]
The Psychotherapy for Postpartum Depression section reports support for IPT and promising results for CBT, while noting that individual CBT has not been adequately investigated. The Psychotherapy for Antenatal Depression section reports improvement with IPT. These passages address depression, not the claimed effectiveness for perinatal anxiety (page numbers unavailable in our copy). (LLM, conf=0.87)
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Authors: DIMIDJIAN, S., & GOODMAN, S.
Affiliations: University of Colorado Boulder (US)
Emory University (US)
Corresponding author: DIMIDJIAN, SONA
ORCID: DIMIDJIAN, SONA
Venue: Clinical Obstetrics & Gynecology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-09
Volume: 52
Issue: 3
Pages: 498-515
ISSN: 0009-9201 (ISSN-L)
DOI: 10.1097/grf.0b013e3181b52da6
PMC: PMC5805470
OpenAlex: W1983494505
Cited by: 99
References: 53
Citations by year: 2026: 2 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 15
FWCI: 1.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Obstetrics & Gynecology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R34MH083866, MH 083866)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: perinatal depression, postpartum depression, antenatal depression, non-pharmacological treatment, depression prevention, maternal mental health, obstetric decision-making
MeSH terms: Depression, Female, Humans, Pregnancy, Pregnancy Complications, Psychotherapy, Cognitive Behavioral Therapy, Treatment Outcome, Depression, Postpartum

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Nonpharmacologic intervention and prevention strategies for depression during pregnancy and the postpartum

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