The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1
Open accessAbstract
The placenta mediates maternal-fetal exchange and has historically been regarded as a passive conduit for nutrients. However, emerging evidence suggests that the placenta actively responds to nutritional and metabolic signals from the mother and the fetus. We propose that the placenta integrates a multitude of maternal and fetal nutritional cues with information from intrinsic nutrient-sensing signaling pathways to match fetal demand with maternal supply by regulating maternal physiology, placental growth, and nutrient transport. This process, which we have called placental nutrient sensing, ensures optimal allocation of resources between the mother and the fetus to maximize the chances for propagation of parental genes without jeopardizing maternal health. We suggest that these mechanisms have evolved because of the evolutionary pressures of maternal undernutrition, which result in decreased placental growth and down-regulation of nutrient transporters, thereby limiting fetal growth to ensure maternal survival. These regulatory loops may also function in response to maternal overnutrition, leading to increased placental growth and nutrient transport in cases of maternal obesity or gestational diabetes. Thus, placental nutrient sensing modulates maternal-fetal resource allocation to increase the likelihood of reproductive success. This model implies that the placenta plays a critical role in mediating fetal programming and determining lifelong health.
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Maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates.
“In addition, maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for the fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates (47, 144, 204, 522, 550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [144]
The responses of the placenta to environmental cues, such as hypoxia and nutrition, indicate that there is significant interaction between maternal nutrient availability and fetal demands for these resources in determining maternal-fetal nutrient allocation at the level of the placenta.
“The responses of the placenta to environmental cues, such as hypoxia and nutrition, indicate that there is significant interaction between maternal nutrient availability and fetal demands for these resources in determining maternal-fetal nutrient allocation at the level of the placenta (74,144).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [144]
This dynamic adaptation in placental phenotype optimises fetal fitness in the prevailing conditions while maintaining sufficient maternal resource for lactation and subsequent pregnancies.
“This dynamic adaptation in placental phenotype optimises fetal fitness in the prevailing conditions while maintaining sufficient maternal resource for lactation and subsequent pregnancies (144, 193).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [144]
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Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works
Living with the Past: Evolution, Development, and Patterns of Disease
Gluckman, P. D., & Hanson, M. A. (2004) · Science · doi:10.1126/science.1095292 · Cited by 1,917 · see citing works
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1029 · Cited by 1,277 · see citing works
Burton, G. J., Woods, A., Jauniaux, E. R. M., & Kingdom, J. C. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.009 · Cited by 1,190 · see citing works
Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress
Jauniaux, E., Watson, A. L., Hempstock, J., Bao, Y.-P., Skepper, J. N., & Burton, G. J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64849-3 · Cited by 1,057 · see citing works
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054 · see citing works
AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
Inoki, K., Kim, J., & Guan, K. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134537 · Cited by 800 · see citing works
Disruption of imprinting caused by deletion of the H19 gene region in mice
Leighton, P. A., Ingram, R. S., Eggenschwiler, J. T., Efstratiadis, A., & Tilghman, S. M. (1995) · Nature · doi:10.1038/375034a0 · Cited by 756 · see citing works
TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738 · see citing works
Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020311 · Cited by 659 · see citing works
Thorvaldsen, J. L., Duran, K. L., & Bartolomei, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.23.3693 · Cited by 648 · see citing works
Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum
MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621 · see citing works
Cardiovascular Function Before, During, and After the First and Subsequent Pregnancies
Clapp, J. F., & Capeless, E. L. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00738-8 · Cited by 535 · see citing works
Signalling to translation: How signal transduction pathways control the protein synthetic machinery
Proud, C. G. (2007) · Biochemical Journal · doi:10.1042/bj20070024 · Cited by 520 · see citing works
GSK-3: Functional Insights from Cell Biology and Animal Models
Kaidanovich‐Beilin, O., & Woodgett, J. R. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00040 · Cited by 487 · see citing works
Placental hormones and the control of maternal metabolism and fetal growth
Newbern, D., & Freemark, M. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32834c800d · Cited by 487 · cited 3× · see citing works
“There is a 60% increase in insulin secretion, which stimulates lipogenesis and reduces fatty acid oxidation, thereby promoting maternal lipid accumulation [8].”
BackgroundInfluentialRegulation of Nutrient Transport across the Placenta
Lager, S., & Powell, T. L. (2012) · Journal of Pregnancy · doi:10.1155/2012/179827 · Cited by 456 · see citing works
Self-citationRegulation of supply and demand for maternal nutrients in mammals by imprinted genes
Reik, W., Constância, M., Fowden, A. L., Anderson, N. F., Dean, W., Ferguson‐Smith, A. C., Tycko, B., & Sibley, C. P. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00035.x · Cited by 409 · see citing works
Modulation of adipokines and cytokines in gestational diabetes and macrosomia
Atègbo, J.-M., Grissa, O., Yessoufou, A., Hichami, A., Dramane, K. L., Moutairou, K., Miled, A., Grissa, A., Jerbi, M., Tabka, Z., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0980 · Cited by 398 · see citing works
Peng, T., Golub, T. R., & Sabatini, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5575-5584.2002 · Cited by 397 · see citing works
Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388 · see citing works
Kovács, C. S., Lanske, B., Hunzelman, J. L., Guo, J., Karaplis, A. C., & Kronenberg, H. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15233 · Cited by 347 · see citing works
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine
Hanover, J. A., Krause, M., & Love, D. C. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.017 · Cited by 342 · see citing works
Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504468103 · Cited by 323 · see citing works
Physiological functions of imprinted genes
Tycko, B., & Morison, I. M. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10129 · Cited by 316 · see citing works
Regulation of supply and demand for maternal nutrients in mammals by imprinted genes
Reik, W., Constância, M., Fowden, A. L., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.033274 · Cited by 315 · see citing works
Jansson, N., Rosario, F. J., Gaccioli, F., Lager, S., Jones, H. N., Roos, S., Jansson, T., & Powell, T. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2667 · Cited by 305 · see citing works
Self-citationMaternal Undernutrition Influences Placental-Fetal Development1
Belkacemi, L., Nelson, D. M., Desai, M., & Ross, M. G. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.084517 · Cited by 299 · see citing works
Glazier, J. D., Cetin, I., Perugino, G., Ronzoni, S., Grey, A. M., Mahendran, D., Marconi, A. M., Pardi, G., & Sibley, C. P. (1997) · Pediatric Research · doi:10.1203/00006450-199710000-00016 · Cited by 287 · see citing works
Roos, S., Jansson, N., Palmberg, I., Säljö, K., Powell, T. L., & Jansson, T. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129676 · Cited by 283 · see citing works
Self-citationPlacental structure and inflammation in pregnancies associated with obesity
Roberts, K., Riley, S. C., Reynolds, R. M., Barr, S., Evans, M., Statham, A., Hor, K., Jabbour, H. N., Norman, J. E., & Denison, F. C. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.023 · Cited by 281 · see citing works
Highman, T. J., Friedman, J. E., Huston, L. P., Wong, W. W., & Catalano, P. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70540-x · Cited by 272 · see citing works
Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism
Catalano, P. M., Hoegh, A. M., Minium, J., Huston-Presley, L., Bernard, S. L., Kalhan, S. C., & Mouzon, S. H. (2006) · Diabetologia · doi:10.1007/s00125-006-0264-x · Cited by 271 · see citing works
Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.550004 · Cited by 265 · see citing works
Self-citationJansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116509 · Cited by 261 · see citing works
Self-citationCetin, I., Corbetta, C., Sereni, L. P., Marconi, A. M., Bozzetti, P., Pardi, G., & Battaglia, F. C. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90860-a · Cited by 259 · see citing works
Jansson, T., & Powell, T. L. (2006) · Placenta · doi:10.1016/j.placenta.2005.11.010 · Cited by 257 · see citing works
Self-citationAmino Acid Transporters in the Human Placenta
Jansson, T. (2001) · Pediatric Research · doi:10.1203/00006450-200102000-00003 · Cited by 245 · see citing works
Self-citationJansson, N., Greenwood, S. L., Johansson, B. R., Powell, T. L., & Jansson, T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021332 · Cited by 243 · see citing works
Self-citationJansson, T., Ekstrand, Y., Björn, C., Wennergren, M., & Powell, T. L. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2214 · Cited by 238 · see citing works
Self-citationPlacental Transport of Leucine and Lysine Is Reduced in Intrauterine Growth Restriction1
Jansson, T., Scholtbach, V., & Powell, T. L. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00011 · Cited by 235 · see citing works
Self-citationImprinted genes in the placenta – A review
Coan, P. M., Burton, G. J., & Ferguson‐Smith, A. C. (2005) · Placenta · doi:10.1016/j.placenta.2004.12.009 · Cited by 231 · see citing works
The H19 gene: regulation and function of a non-coding RNA
Gabory, A., Ripoche, M., Yoshimizu, T., & Dandolo, L. (2006) · Cytogenetic and Genome Research · doi:10.1159/000090831 · Cited by 227 · see citing works
Maternal vasodilation in pregnancy: the emerging role of relaxin
Conrad, K. P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00156.2011 · Cited by 222 · see citing works
Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control
Longo, L. D. (1983) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1983.245.5.r720 · Cited by 221 · see citing works
Jansson, T., Ylvén, K., Wennergren, M., & Powell, T. L. (2002) · Placenta · doi:10.1053/plac.2002.0826 · Cited by 218 · see citing works
Self-citationHuman placental growth hormone causes severe insulin resistance in transgenic mice
Barbour, L. A., Shao, J., Qiao, L., Pulawa, L. K., Jensen, D. R., Bartke, A., Garrity, M., Draznin, B., & Friedman, J. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.121256 · Cited by 214 · see citing works
Blood glucose and oxygen tension levels in small-for-gestational-age fetuses
Economides, D. L., & Nicolaides, K. H. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90453-5 · Cited by 208 · see citing works
Barbour, L. A., Shao, J., Qiao, L., Leitner, W., Anderson, M., Friedman, J. E., & Draznin, B. (2004) · Endocrinology · doi:10.1210/en.2003-1297 · Cited by 208 · see citing works
Mirlesse, V., Frankenne, F., Alsat, E., Poncelet, M., Hennen, G., & Evain-Brion, D. (1993) · Pediatric Research · doi:10.1203/00006450-199310000-00011 · Cited by 202 · see citing works
Adiponectin in Human Cord Blood: Relation to Fetal Birth Weight and Gender
Sivan, E., Mazaki‐Tovi, S., Pariente, C., Efraty, Y., Schiff, E., Hemi, R., & Kanety, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031174 · Cited by 202 · see citing works
Zhao, Y., Altman, B. J., Coloff, J. L., Herman, C. E., Jacobs, S. R., Wieman, H. L., Wofford, J. A., DiMascio, L. N., Ilkayeva, O., Kelekar, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00153-07 · Cited by 193 · see citing works
Rosario, F. J., Kanai, Y., Powell, T. L., & Jansson, T. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238014 · Cited by 185 · see citing works
Self-citationCord Blood Leptin and Insulin-Like Growth Factor Levels are Independent Predictors of Fetal Growth
Christou, H. A., Connors, J. M., Ziotopoulou, M., Hatzidakis, V., Papathanassoglou, E. D. E., Ringer, S. A., & Mantzoros, C. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7217 · Cited by 185 · see citing works
Placental nutrient supply and fetal growth
Desforges, M., & Sibley, C. P. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082765md · Cited by 182 · see citing works
Burton, G. J., & Fowden, A. L. (2012) · Placenta · doi:10.1016/j.placenta.2011.11.013 · Cited by 177 · see citing works
Human Placental Growth Hormone—A Review
Lacroix, M. C., Guibourdenche, J., Frendo, J., MULLER, F. M., & Evain‐Brion, D. (2002) · Placenta · doi:10.1053/plac.2002.0811 · Cited by 177 · see citing works
Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176 · see citing works
Self-citationRole of placental nutrient sensing in developmental programming
JANSSON, T., & POWELL, T. L. (2013) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182993a2e · Cited by 172 · see citing works
Self-citationLowe, L. P., Metzger, B. E., Lowe, W. L., Dyer, A. R., McDade, T. W., & McIntyre, D. H. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1662 · Cited by 172 · see citing works
Jones, H. N., Jansson, T., & Powell, T. L. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2009 · Cited by 168 · cited 2× · see citing works
“Moreover, the activation of trophoblast system A activity by IL-6, leptin, and oleic acid appears to involve the transcription factor STAT-3 [49, 52, 53], indicating that there are common pathways to integrate and ‘‘sense’’ different maternal metabolic cues.”
BackgroundSelf-citationRoos, S., Lagerlöf, O., Wennergren, M., Powell, T. L., & Jansson, T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2009 · Cited by 168 · see citing works
Self-citationThe emerging role of mTORC1 signaling in placental nutrient-sensing
Jansson, T., Aye, I. L. M. H., & Goberdhan, D. C. I. (2012) · Placenta · doi:10.1016/j.placenta.2012.05.010 · Cited by 167 · see citing works
Self-citationControl of vascular resistance in the human placenta
Myatt, L. (1992) · Placenta · doi:10.1016/0143-4004(92)90057-z · Cited by 164 · see citing works
Maternal hormones linking maternal body mass index and dietary intake to birth weight
Jansson, N., Nilsfelt, A., Gellerstedt, M., Wennergren, M., Rossander-Hulthén, L., Powell, T. L., & Jansson, T. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1743 · Cited by 159 · see citing works
Self-citationThe Mechanisms and Regulation of Placental Amino Acid Transport to the Human Foetus
Cleal, J. K., & Lewis, R. M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01662.x · Cited by 157 · see citing works
Aye, I. L. M. H., Powell, T. L., & Jansson, T. (2012) · Placenta · doi:10.1016/j.placenta.2012.11.024 · Cited by 151 · see citing works
Self-citationLaviola, L., Perrini, S., Belsanti, G., Natalicchio, A., Montrone, C., Leonardini, A., Vimercati, A., Scioscia, M., Selvaggi, L. E., GIORGINO, R., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1332 · Cited by 151 · see citing works
Regulation of placental amino acid transporter activity by mammalian target of rapamycin
Roos, S., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00330.2008 · Cited by 150 · see citing works
Self-citationMalandro, M. S., Beveridge, M. J., Kilberg, M. S., & Novak, D. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c295 · Cited by 150 · see citing works
Plasma catecholamine responses to physiologic stimuli in normal human pregnancy
Barron, W. M., MUJAIS, S. K., Zinaman, M. J., Bravo, E. L., & Lindheimer, M. D. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90397-2 · Cited by 148 · see citing works
The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells
Kilberg, M. S., Balasubramanian, M. N., Fu, L., & Shan, J. (2012) · Advances in Nutrition · doi:10.3945/an.112.001891 · Cited by 143 · see citing works
Zhu, M. J., Ma, Y., Long, N. M., Du, M., & Ford, S. P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00309.2010 · Cited by 137 · see citing works
Sferruzzi‐Perri, A. N., Vaughan, O. R., Haro, M., Cooper, W. N., Musial, B., Charalambous, M., Pestana, D., Ayyar, S., Ferguson‐Smith, A. C., Burton, G. J., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-234823 · Cited by 134 · see citing works
Kavitha, J., Rosario, F. J., Nijland, M. J., McDonald, T. J., Wu, G., Kanai, Y., Powell, T. L., Nathanielsz, P. W., & Jansson, T. (2013) · The FASEB Journal · doi:10.1096/fj.13-242271 · Cited by 131 · see citing works
Self-citationMaternal serum adiponectin levels during human pregnancy
Mazaki‐Tovi, S., Kanety, H., Pariente, C., Hemi, R., Wiser, A., Schiff, E., & Sivan, E. (2007) · Journal of Perinatology · doi:10.1038/sj.jp.7211639 · Cited by 130 · see citing works
Jones, H. N., Jansson, T., & Powell, T. L. (2010) · Diabetes · doi:10.2337/db09-0824 · Cited by 130 · see citing works
Self-citationPlacental transport in response to altered maternal nutrition
Gaccioli, F., Lager, S., Powell, T. L., & Jansson, T. (2013) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000529 · Cited by 129 · see citing works
Self-citationKudo, Y., & Boyd, C. A. R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0405i.x · Cited by 121 · see citing works
Freemark, M. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091505 · Cited by 118 · see citing works
Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice
Sferruzzi-Perri, A. N., Vaughan, O. R., Coan, P. M., Suciu, M. C., Darbyshire, R., Constancia, M., Burton, G. J., & Fowden, A. L. (2011) · Endocrinology · doi:10.1210/en.2011-0240 · Cited by 115 · see citing works
Maternal-fetal resource allocation: Co-operation and conflict
Fowden, A. L., & Moore, T. (2012) · Placenta · doi:10.1016/j.placenta.2012.05.002 · Cited by 114 · see citing works
Karl, P. I. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041650111 · Cited by 112 · see citing works
Yung, H. W., Cox, M., van Patot, M. T., & Burton, G. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-190082 · Cited by 112 · see citing works
Kuruvilla, A. G., D'Souza, S. W., Glazier, J. D., Mahendran, D., Maresh, M., & Sibley, C. P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117386 · Cited by 107 · see citing works
Rosario, F. J., Schumacher, M. A., Jiang, J. X., Kanai, Y., Powell, T. L., & Jansson, T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226399 · Cited by 102 · see citing works
Self-citationAye, I. L. M. H., Jansson, T., & Powell, T. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.013 · Cited by 95 · see citing works
Self-citationSibley, C. P., Brownbill, P., Dilworth, M. R., & Glazier, J. D. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.020 · Cited by 95 · see citing works
Desoyé, G., Hahn, T., Hartmann, M., Blaschitz, A., Dohr, G., Kohnen, G., & Kaufmann, P. (1994) · Histochemistry and Cell Biology · doi:10.1007/bf00315915 · Cited by 93 · see citing works
Dilworth, M. R., Kusinski, L. C., Cowley, E. J., Ward, B. S., Husain, S. M., Constância, M., Sibley, C. P., & Glazier, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911710107 · Cited by 86 · see citing works
Leptin Receptor in Human Term Placenta: in Situ Hybridization and Immunohistochemical Localization
Bodner, J., Ebenbichler, C. F., Wolf, H. J., Müller‐Holzner, E., Stanzl, U., Gander, R., Huter, O., & Patsch, J. R. (1999) · Placenta · doi:10.1053/plac.1999.0431 · Cited by 85 · see citing works
Godfrey, K. M., Matthews, N., Glazier, J. D., Jackson, A. A., Wilman, C., & Sibley, C. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5132 · Cited by 85 · see citing works
Expression and regulation of 4F2hc and hLAT1 in human trophoblasts
Okamoto, Y., Sakata, M., Ogura, K., Yamamoto, T., Yamaguchi, M., Tasaka, K., Kurachi, H., Tsurudome, M., & Murata, Y. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2002.282.1.c196 · Cited by 79 · see citing works
Pastore, M. B., Jobe, S. O., Ramadoss, J., & Magness, R. R. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1299597 · Cited by 77 · see citing works
Gaccioli, F., White, V., Capobianco, E., Powell, T. L., Jawerbaum, A., & Jansson, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109702 · Cited by 76 · see citing works
Self-citationMaternal amino acid supplementation for intrauterine growth restriction
Rozance, P. J. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s162 · Cited by 76 · see citing works
Adiponectin Inhibits Insulin Function in Primary Trophoblasts by PPARα-Mediated Ceramide Synthesis
Aye, I. L. M. H., Gao, X., Weintraub, S. T., Jansson, T., & Powell, T. L. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1401 · Cited by 75 · see citing works
Self-citationMaternal corticosterone regulates nutrient allocation to fetal growth in mice
Vaughan, O. R., Sferruzzi‐Perri, A. N., & Fowden, A. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239426 · Cited by 75 · see citing works
Roberts, C. T., Owens, J. A., & Sferruzzi-Perri, A. N. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.002 · Cited by 74 · see citing works
Godfrey, K. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3320 · Cited by 72 · see citing works
von Versen‐Höynck, F., Rajakumar, A., Parrott, M. S., & Powers, R. W. (2009) · Placenta · doi:10.1016/j.placenta.2009.01.004 · Cited by 71 · see citing works
Human placental amino acid transporter genes: expression and function
Kudo, Y., & Boyd, C. A. R. (2002) · Reproduction · doi:10.1530/rep.0.1240593 · Cited by 71 · see citing works
Cetin, I., Marconi, A. M., Corbetta, C., Lanfranchi, A. K., Baggiani, A., Battaglia, F. C., & Pardi, G. (1992) · Early Human Development · doi:10.1016/0378-3782(92)90136-5 · Cited by 70 · see citing works
Angiolini, E., Coan, P. M., Sandovici, I., Iwajomo, O. H., Peck, G., Burton, G. J., Sibley, C. P., Reik, W., Fowden, A. L., & Constância, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-175273 · Cited by 64 · see citing works
Lager, S., Gaccioli, F., Ramirez, V. I., Jones, H. N., Jansson, T., & Powell, T. L. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m033050 · Cited by 61 · see citing works
Self-citationIncreased maternofetal calcium flux in parathyroid hormone‐related protein‐null mice
Bond, H., Dilworth, M. R., Baker, B., Cowley, E. J., Jimenez, A. R., Boyd, R. D. H., Husain, S. M., Ward, B. S., Sibley, C. P., & Glazier, J. D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.149104 · Cited by 60 · see citing works
Strid, H., Bucht, E., Jansson, T., Wennergren, M., & Powell, T. L. (2003) · Placenta · doi:10.1053/plac.2002.0941 · Cited by 60 · see citing works
Self-citationScott, P.-A., Tremblay, A., Brochu, M., & St‐Louis, J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00736.2007 · Cited by 59 · see citing works
Corcoran, J. J., Nicholson, C., Sweeney, M., Charnock, J. C., Robson, S. C., Westwood, M., & Taggart, M. J. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat095 · Cited by 59 · see citing works
Ma, Y., Zhu, M. J., Uthlaut, A. B., Nijland, M. J., Nathanielsz, P. W., Hess, B. W., & Ford, S. P. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.007 · Cited by 58 · see citing works
Spatial Polarization of Insulin-Like Growth Factor Receptors on the Human Syncytiotrophoblast
Fang, J., Furesz, T. C., Laurent, R. S., Smith, C. H., & Fant, M. E. (1997) · Pediatric Research · doi:10.1203/00006450-199702000-00017 · Cited by 55 · see citing works
Zhu, M. J., Du, M., Nijland, M. J., Nathanielsz, P. W., Hess, B. W., Moss, G. E., & Ford, S. P. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.001 · Cited by 54 · see citing works
Adiponectin Enhances Mouse Fetal Fat Deposition
Qiao, L., Yoo, H. S., Madon, A., Kinney, B., Hay, W. W., & Shao, J. (2012) · Diabetes · doi:10.2337/db12-0055 · Cited by 53 · see citing works
Street, M. E., Viani, I., Ziveri, M. A., Volta, C., Smerieri, A., & Bernasconi, S. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0752 · Cited by 50 · see citing works
Arroyo, J. A., Brown, L. D., & Galan, H. L. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.031 · Cited by 47 · see citing works
Audette, M. C., Challis, J. R. G., Jones, R. L., Sibley, C. P., & Matthews, S. G. (2011) · Endocrinology · doi:10.1210/en.2011-0104 · Cited by 47 · see citing works
Smerieri, A., Petraroli, M., Ziveri, M. A., Volta, C., Bernasconi, S., & Street, M. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029562 · Cited by 46 · see citing works
Strid, H., Care, A. D., Jansson, T., & Powell, T. L. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750517 · Cited by 43 · see citing works
Self-citationZhu, M. J., Du, M., Hess, B. W., Nathanielsz, P. W., & Ford, S. P. (2007) · Placenta · doi:10.1016/j.placenta.2007.05.004 · Cited by 41 · see citing works
Strakovsky, R. S., Zhou, D., & Pan, Y. (2010) · Journal of Nutrition · doi:10.3945/jn.110.127803 · Cited by 39 · see citing works
Alsat, E., Mirlesse, V., Frankenne, F., Poncelet, M., Hennen, G. P., & Evain‐Brion, D. (1993) · Placenta · doi:10.1016/s0143-4004(05)80469-2 · Cited by 34 · see citing works
Tavaré, J. M., & Holmes, C. H. (1989) · Cellular Signalling · doi:10.1016/0898-6568(89)90020-x · Cited by 32 · see citing works
Altitude and fetal growth: current knowledge and future directions
Zamudio, S., & MOORE, L. G. (2000) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.2000.00155.x · Cited by 28 · see citing works
Fang, J., Mao, D., Smith, C. H., & Fant, M. E. (2006) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2006.08.002 · Cited by 28 · see citing works
Sideri, M. G., de Virgiliis, G., Rainoldi, R., & Remotti, G. (1984) · Springer eBooks · doi:10.1007/978-1-4684-1191-1_3 · Cited by 22 · see citing works
l-Methionine Placental Uptake: Characterization and Modulation in Gestational Diabetes Mellitus
Araújo, J. R., Correia‐Branco, A., Ramalho, C. M. A., Gonçalves, P., Pinho, M. J., Keating, E., & Martel, F. (2013) · Reproductive Sciences · doi:10.1177/1933719113488442 · Cited by 21 · see citing works
Acharya, G., Albrecht, C., Benton, S. J., Cotechini, T., Dechend, R., Dilworth, M. R., Duttaroy, A. K., Grotmol, T., Heazell, A. E. P., Jansson, T., et al. (2011) · Placenta · doi:10.1016/j.placenta.2011.11.015 · Cited by 9 · see citing works
Self-citationMehta, A. R., & Mehta, P. R. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.151332 · Cited by 6 · see citing works
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Catalano, P. M., & Shankar, K. (2017) · BMJ · doi:10.1136/bmj.j1 · Cited by 1,306 · see citing works
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470 · see citing works
Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
Dimasuay, K. G., Boeuf, P., Powell, T. L., & Jansson, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00012 · Cited by 258 · see citing works
Self-citationHemochorial placentation: development, function, and adaptations†
Soares, M. J., Varberg, K. M., & Iqbal, K. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy049 · Cited by 194 · see citing works
Reversing the Effects of Maternal Obesity
Schubert, C. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.136119 · Cited by 170 · see citing works
Aye, I. L. M. H., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515484112 · Cited by 163 · see citing works
Self-citationColson, A., Sonveaux, P., Debiève, F., & Sferruzzi-Perri, A. N. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa053 · Cited by 145 · see citing works
Regulation of Placental Amino Acid Transport and Fetal Growth
Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.008 · Cited by 130 · see citing works
Self-citationShao, X., Cao, G., Chen, D., Liu, J., Yu, B., Liu, M., Li, Y., Cao, B., Sadovsky, Y., & Wang, Y. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017092118 · Cited by 129 · see citing works
Gerhardt, K. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.142240 · Cited by 126 · see citing works
Albers, R. E., Kaufman, M. R., Natale, B. V., Keoni, C., Kulkarni-Datar, K. S., Min, S., Williams, C. R., Natale, D. R. C., & Brown, T. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-39426-5 · Cited by 110 · see citing works
Rosario, F. J., Dimasuay, K. G., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Clinical Science · doi:10.1042/cs20150554 · Cited by 102 · see citing works
Self-citationHiggins, J., Vaughan, O. R., de Liger, E. F., Fowden, A. L., & Sferruzzi-Perri, A. N. (2015) · The Journal of Physiology · doi:10.1113/jp271057 · Cited by 102 · see citing works
Chen, S., Sun, F.-Z., Huang, X.-Y., Wang, X., Tang, N., Zhu, B., & Li, B. (2015) · Scientific Reports · doi:10.1038/srep10596 · Cited by 94 · see citing works
Nutrient sensor signaling pathways and cellular stress in fetal growth restriction
Hart, B. G., Morgan, E., & Alejandro, E. U. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0059 · Cited by 90 · see citing works
Gaccioli, F., Aye, I. L. M. H., Roos, S., Lager, S., Ramirez, V. I., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0054-8 · Cited by 85 · see citing works
Self-citationFetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene
López‐Tello, J., Yong, H. E. J., Sandovici, I., Dowsett, G. K. C., Christoforou, E. R., Salazar‐Petres, E., Boyland, R., Napso, T., Yeo, G. S. H., Lam, B., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.007 · Cited by 83 · see citing works
Tain, Y., & Hsu, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040841 · Cited by 79 · see citing works
Díaz, P., Harris, J., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00385.2015 · Cited by 72 · see citing works
Self-citationNovel roles of mechanistic target of rapamycin signaling in regulating fetal growth†
Gupta, M. B., & Jansson, T. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy249 · Cited by 69 · see citing works
Self-citationLarson, K., Bundy, A. N., & Roemmich, J. N. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108373 · Cited by 69 · see citing works
Chassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 66 · see citing works
Self-citationPlacental imprinting variation associated with assisted reproductive technologies and subfertility
Litzky, J. F., Deyssenroth, M. A., Everson, T. M., Armstrong, D. A., Lambertini, L., Chen, J., & Marsit, C. J. (2017) · Epigenetics · doi:10.1080/15592294.2017.1336589 · Cited by 66 · see citing works
The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy
Behura, S. K., Dhakal, P., Kelleher, A. M., Balboula, A. Z., Patterson, A. L., & Spencer, T. E. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104468 · Cited by 63 · see citing works
Capobianco, E., Fornes, D. D., Linenberg, I. M., Powell, T. L., Jansson, T., & Jawerbaum, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.020 · Cited by 59 · see citing works
Self-citationZhang, S., Cheng, Z., Zhang, T., Ding, Y., Zhu, H., Wang, L., & Sun, H. (2025) · Nature Communications · doi:10.1038/s41467-025-56552-z · Cited by 53 · see citing works
Wankhade, U. D., Thakali, K. M., & Shankar, K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.001 · Cited by 48 · see citing works
Aye, I. L. M. H., Jansson, T., & Powell, T. L. (2015) · Physiological Reports · doi:10.14814/phy2.12594 · Cited by 44 · see citing works
Self-citationChortarea, S., Gupta, G. S., Saarimäki, L. A., Netkueakul, W., Manser, P., Aengenheister, L., Wichser, A., Fortino, V., Wick, P., Greco, D., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108015 · Cited by 42 · see citing works
Placenta plays a critical role in maternal–fetal resource allocation
Jansson, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613437113 · Cited by 40 · see citing works
Self-citationLi, B., Chen, S., Tang, N., Xiao, X., Huang, J., Jiang, F., Huang, X.-Y., Sun, F.-Z., & Wang, X. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.136051 · Cited by 39 · see citing works
Day, P. E., Ntani, G., Crozier, S., Mahon, P. A., Inskip, H. M., Cooper, C. C., Harvey, N. C., Godfrey, K. M., Hanson, M. A., Lewis, R. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143653 · Cited by 38 · see citing works
Litzky, J. F., Deyssenroth, M. A., Everson, T. M., Lester, B. M., Lambertini, L., Chen, J., & Marsit, C. J. (2018) · Pediatric Research · doi:10.1038/pr.2018.27 · Cited by 36 · see citing works
Duan, Y., Sun, F., Que, S., Li, Y., Yang, S., & Liu, G. (2017) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2017.01.002 · Cited by 32 · see citing works
Comparative transcriptomic analysis of human placentae at term and preterm delivery†
Paquette, A. G., Brockway, H., Price, N. D., & Muglia, L. J. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox163 · Cited by 32 · see citing works
Brockway, H., Kallapur, S. G., Buhimschi, I. A., Buhimschi, C. S., Ackerman, W. E., Muglia, L. J., & Jones, H. N. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225062 · Cited by 33 · see citing works
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health
Cleal, J. K., Poore, K. R., & Lewis, R. M. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101095 · Cited by 33 · see citing works
Yung, H. W., Zhao, X., Glover, L., Burrin, C., Pang, P., Jones, C. J. P., Gill, C. A., Duhig, K. E., Olovsson, M. H., Chappell, L. C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105911 · Cited by 32 · see citing works
Karimi‐Zarchi, M., Zanbagh, L., Javaheri, A., Tabatabaei, R. S., Abbasi, H., Meibodi, B., Hadadan, A., Bahrami, R., Mirjalili, S. R., & Neámatzadeh, H. (2020) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2020.1745970 · Cited by 30 · see citing works
Obesity downregulates lipid metabolism genes in first trimester placenta
Rasool, A., Mahmoud, T. G., Mathyk, B. A., Kaneko-Tarui, T., Roncari, D., White, K. O., & O’Tierney-Ginn, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-24040-9 · Cited by 30 · see citing works
Díaz, P., Dimasuay, K. G., Koele‐Schmidt, L., Jang, B., Barbour, L. A., Jansson, T., & Powell, T. L. (2017) · Placenta · doi:10.1016/j.placenta.2017.05.016 · Cited by 30 · see citing works
Self-citationChin, E. H., Schmidt, K. L., Martel, K. M., Wong, C. K., Hamden, J. E., Gibson, W. T., Soma, K. K., & Christians, J. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174030 · Cited by 28 · see citing works
Yang, X., Zhou, Y., Li, H., Song, F., Li, J., Zhang, Y. J., Lin, Y., Zhang, H., Fan, J., & Wu, W. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30774 · Cited by 27 · see citing works
TFEB safeguards trophoblast syncytialization in humans and mice
Zheng, W., Zhang, Y., Xu, P., Wang, Z., Shao, X., Chen, C., Cai, H., Wang, Y., Sun, M.-A., Deng, W., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404062121 · Cited by 26 · see citing works
Assumpção, R. P., Mucci, D. D. B., da Fonseca, F. C. P., Marcondes, H., Sardinha, F. L. C., Citelli, M., & do Carmo, M. G. T. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.08.011 · Cited by 26 · see citing works
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
Menendez-Montes, I., Escobar, B., Gómez, M. J., Albendea-Gomez, T., Palacios, B., Bonzón‐Kulichenko, E., Izquierdo-García, J. L., Alonso, A. V., Ferrarini, A., Jiménez‐Borreguero, L. J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102124 · Cited by 26 · see citing works
Maternal Underweight and Obesity Are Associated with Placental Pathologies in Human Pregnancy
Scott, H., Grynspan, D., Anderson, L. N., & Connor, K. L. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00983-2 · Cited by 28 · see citing works
Sferruzzi-Perri, A. N. (2018) · Placenta · doi:10.1016/j.placenta.2018.01.005 · Cited by 24 · see citing works
Castillo‐Castrejón, M., Jansson, T., & Powell, T. L. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2019 · Cited by 25 · see citing works
Self-citationCastillo‐Castrejón, M., Yamaguchi, K., Rodel, R. L., Erickson, K., Kramer, A. W., Hirsch, N. M., Rolloff, K. P., Jansson, T., Barbour, L. A., & Powell, T. L. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111319 · Cited by 24 · see citing works
Self-citationMangwiro, Y. T. M., Cuffe, J. S. M., Mahizir, D., Anevska, K., Gravina, S., Romano, T., Moritz, K. M., Briffa, J. F., & Wlodek, M. E. (2019) · The Journal of Physiology · doi:10.1113/jp277227 · Cited by 24 · see citing works
Sun, L., Guo, Y., Fan, Y., Nie, H., Wang, R., & Wang, F. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.01.025 · Cited by 23 · see citing works
Thakali, K. M., Zhong, Y., Cleves, M., Andres, A., & Shankar, K. (2020) · Placenta · doi:10.1016/j.placenta.2020.02.018 · Cited by 26 · see citing works
Arias, A., Schander, J. A., Bariani, M. V., Correa, F., Rubio, A. P. D., Cella, M., Cymeryng, C. B., Wolfson, M. L., Franchi, A. M., & Aisemberg, J. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab006 · Cited by 21 · see citing works
The microbiome as a modulator of neurological health across the maternal-offspring interface
Orchanian, S. B., & Hsiao, E. Y. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184314 · Cited by 22 · see citing works
Moore, M., Avula, N., Jo, S., Beetch, M., & Alejandro, E. U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136918 · Cited by 21 · see citing works
Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview
Toschi, P., & Baratta, M. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.755034 · Cited by 21 · see citing works
Gibson, C. M. E., de Ruijter‐Villani, M., & Stout, T. A. E. (2017) · Placenta · doi:10.1016/j.placenta.2017.07.007 · Cited by 21 · see citing works
Litzky, J. F., & Marsit, C. J. (2019) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-019-01483-0 · Cited by 21 · see citing works
Hung, S.-C., Chan, T., Chan, H., Wu, C., Chan, M.-L., Jhuang, J., Tan, J.-Q., Mei, J.-B., Law, S., Ponnusamy, V. K., et al. (2024) · Antioxidants · doi:10.3390/antiox13081007 · Cited by 19 · see citing works
Liu, G., Deng, W., Cui, W., Xie, Q., Zhao, G., Wu, X., Lijuan, D., Chen, D., & Yu, B. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1560407 · Cited by 19 · see citing works
The energy resistance principle
Picard, M. A., & Murugan, N. J. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.002 · Cited by 17 · see citing works
Rogers, J. M., Heintz, M. M., Thompson, C. M., & Haws, L. C. (2023) · Birth Defects Research · doi:10.1002/bdr2.2185 · Cited by 19 · see citing works
Francis, E. C., Dabelea, D., Boyle, K. E., Jansson, T., & Perng, W. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab403 · Cited by 18 · see citing works
Self-citationChen, Z., He, M., Wang, H., Li, X., Qin, R., Ding, Y., Zhai, X., Zhu, J., Zhang, Q., Hu, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54258-2 · Cited by 17 · see citing works
Shokrollahi, B., Park, M., Jang, G.-S., Jin, S., Moon, S.-J., Um, K.-H., Jang, S.-S., & Baek, Y.-C. (2025) · Biology · doi:10.3390/biology14060645 · Cited by 16 · see citing works
Intrauterine growth restriction: screening and diagnosis using animal models
Felicioni, F., Santos, T. G., Paula, T. D. M. D. E., Chiarini‐Garcia, H., & de Almeida, F. R. C. L. (2019) · Animal Reproduction · doi:10.21451/1984-3143-ar2018-0127 · Cited by 16 · see citing works
Song, L., Yan, J., Wang, N., Wei, X., Luo, X. M., Meng, K., & Sun, B. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz213 · Cited by 15 · see citing works
Lactic Acid Transport Mediated by Aquaporin-9: Implications on the Pathophysiology of Preeclampsia
Medina, Y., Acosta, L. H., Reppetti, J., Corominas, A. I., Bustamante, J., Szpilbarg, N., & Damiano, A. E. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.774095 · Cited by 15 · see citing works
Metabolic control of feto–placental development and pregnancy outcomes
Gao, Y., Yu, X., Wang, Y., Wang, H., Wang, Y., & Shyh‐Chang, N. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01206-9 · Cited by 18 · see citing works
Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development
Marinello, W. P., & Patisaul, H. B. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.04.003 · Cited by 14 · see citing works
Ruebel, M. L., Borengasser, S. J., Zhong, Y., Kang, P., Faske, J. B., & Shankar, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216441 · Cited by 14 · see citing works
Widatalla, N., Khandoker, A. H., Alkhodari, M., Koide, K., Yoshida, C., Kasahara, Y., Kimura, Y., & Saito, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.964755 · Cited by 14 · see citing works
Ortiz-Román, M. I., Casiano-Muñiz, I. M., & Román, F. R. (2024) · Nanomaterials · doi:10.3390/nano14040373 · Cited by 13 · see citing works
Gardner, J. J., Cushen, S. C., da Silva, R. D. N. O., Bradshaw, J. L., Hula, N., Gorham, I. K., Tucker, S. M., Zhou, Z., Cunningham, R. L., Phillips, N., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00091.2024 · Cited by 12 · see citing works
The placental gateway of maternal transgenerational epigenetic inheritance
Sailasree, P., Srivastava, S., & Mishra, R. K. (2017) · Journal of Genetics · doi:10.1007/s12041-017-0788-5 · Cited by 12 · see citing works
Gaps in the knowledge of thyroid hormones and placental biology
Pereira‐Carvalho, D., Dias, A. F., Sferruzzi-Perri, A. N., & Ortiga-Carvalho, T. M. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac006 · Cited by 12 · see citing works
Environmental Forces that Shape Early Development: What We Know and Still Need to Know
Shankar, K., Pivik, R. T., Johnson, S. L., van Ommen, B., Demmer, E., & Murray, R. D. (2017) · Current Developments in Nutrition · doi:10.3945/cdn.117.001826 · Cited by 11 · see citing works
Aldahmash, W., Harrath, A. H., Aljerian, K., Sabr, Y., & Alwasel, S. H. (2023) · Life · doi:10.3390/life13040993 · Cited by 11 · see citing works
Assessment of Placental Transport Function in Studies of Disease Programming
Sferruzzi-Perri, A. N. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_14 · Cited by 10 · see citing works
Gurner, K. H., Truong, T. T., Harvey, A. J., & Gardner, D. K. (2020) · Molecular Human Reproduction · doi:10.1093/molehr/gaaa072 · Cited by 11 · see citing works
Dhakal, P., Strawn, M., Samal, A., & Behura, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189693 · Cited by 11 · see citing works
Tong, W., Allison, B. J., Brain, K. L., Patey, O. V., Niu, Y., Botting, K. J., Ford, S. G., Garrud, T. A. C., Wooding, F. B. P., Lyu, Q., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287897 · Cited by 14 · see citing works
Influence of Maternal Diet and Environmental Factors on Fetal Development
Duttaroy, A. K. (2023) · Nutrients · doi:10.3390/nu15194094 · Cited by 10 · see citing works
McCoard, S. A., Haack, N. A., Heiser, A., & Maclean, P. H. (2023) · Theriogenology · doi:10.1016/j.theriogenology.2023.03.009 · Cited by 9 · see citing works
Tossetta, G., Campagna, R., Vignini, A., Maruotti, G. M., Motta, M., Murolo, C., Sarno, L., Grelloni, C., Cecati, M., Giannubilo, S. R., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020919 · Cited by 9 · see citing works
Embryotoxic effects of Poincianella ( Caesalpinia ) pyramidalis leaves on pregnant rats
Câmara, A. C. L., Gadelha, I. C. N., de Castro, M. B., Medeiros, R. M. T., Riet-Corrêa, F., & Soto‐Blanco, B. (2017) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638716682564 · Cited by 9 · see citing works
Schiera, G., Macajone, G., Volpes, S., Greco, L., Di Liegro, C. M., Serio, G., Caradonna, F., & Naselli, F. (2026) · Cells · doi:10.3390/cells15040366 · Cited by 8 · see citing works
Candia‐Rivera, D., & Chávez, M. (2025) · Experimental Physiology · doi:10.1113/ep092532 · Cited by 7 · see citing works
Akbar, A., DuVall, S. L., VanOrmer, M., Slotkowski, R., Hahka, T. M., Genaro‐Mattos, T. C., Korade, Ž., Hanson, C., Anderson‐Berry, A., & Thoene, M. K. (2023) · Nutrients · doi:10.3390/nu15112553 · Cited by 8 · see citing works
Placental Trophoblast-Inspired Lipid Bilayers for Cell-Free Investigation of Molecular Interactions
Bailey‐Hytholt, C. M., Shen, T., Nie, B., Tripathi, A., & Shukla, A. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c06197 · Cited by 8 · see citing works
Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
Kelly, A. C., Chan, J., Powell, T. L., Cox, L. A., Jansson, T., & Rosario, F. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1178533 · Cited by 10 · see citing works
Self-citationGouvêa, V. N., Smithyman, M. M., Hentz, F., Bagheri, N., & Batistel, F. (2024) · Journal of Animal Science · doi:10.1093/jas/skae305 · Cited by 7 · see citing works
Castro, M. D. L., dos Passos, R. R., Justina, V. D., do Amaral, W. N., & Giachini, F. R. C. (2023) · Placenta · doi:10.1016/j.placenta.2023.04.018 · Cited by 7 · see citing works
Joshi, N. P., Sahay, A. S., Mane, A. R., Sundrani, D. P., Randhir, K., Wagh, G. N., Thornburg, K. L. R., Powell, T. L., Yajnik, C. S., & Joshi, S. (2023) · Placenta · doi:10.1016/j.placenta.2023.07.001 · Cited by 7 · see citing works
Self-citationMaternal BMI and Diet Quality Modulate Pregnancy Oxidative and Inflammatory Homeostasis
Mandò, C., Novielli, C., Nuzzo, A. M., Parisi, F., Moretti, L., Lisso, F., Revelli, A., Savasi, V. M., Laoreti, A., Anelli, G. M., et al. (2025) · Nutrients · doi:10.3390/nu17162590 · Cited by 7 · see citing works
Mahindra, M. P., Jie, M., Mapindra, M. P., Rehman, S., Vaughan, O. R., Hillman, S. L., David, A. L., & Siassakos, D. M. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-08016-x · Cited by 6 · see citing works
The impact of obesity on placental vascular development and function
Ramanlal, I., James, J. L., & Boss, A. L. (2026) · Molecular Human Reproduction · doi:10.1093/molehr/gaag002 · Cited by 7 · see citing works
Spontaneous Preterm Birth: a Fetal-Maternal Metabolic Imbalance
Battat, T. L., & Erez, O. (2023) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000205 · Cited by 6 · see citing works
- Authors
- Díaz, P., Powell, T. L., & Jansson, T.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Díaz, Paula
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-10-01
- Volume
- 91
- Issue
- 4
- Pages
- 82-82
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- PMC
- PMC4435028
- OpenAlex
- W2151264384
- Cited by
- 158
- References
- 128
- Citations by year
- 2026: 19 · 2025: 16 · 2024: 11 · 2023: 18 · 2022: 11 · 2021: 14 · 2020: 8 · 2019: 12 · 2018: 12 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- National Institutes of Health (5r01hd068370-11, HD065007, HD068370)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989, DK089989)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071306, R01-HD068370, HD065007, R01HD065007, HD071306, HD 068370)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- placental development, nutrient transporters, maternal-fetal nutrient exchange, maternal undernutrition, maternal overnutrition, maternal obesity, gestational diabetes mellitus, fetal programming, evolutionary pressure, placenta
- MeSH terms
- Animals, Biological Transport, Female, Maternal-Fetal Exchange, Placenta, Pregnancy, Prenatal Nutritional Physiological Phenomena
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