Osteopontin characterizes bile duct–associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

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Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice

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Immunoregulatory Roles of Osteopontin in Diseases

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Targeted Macrophage CRISPR‐Cas13 mRNA Editing in Immunotherapy for Tendon Injury

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Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming

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Immunobiology of primary sclerosing cholangitis

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Zonation, Zonation, Zonation: The Real Estate of the Liver

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Communication initiated by hepatocytes: The driver of HSC activation and liver fibrosis

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Myeloid cells in chronic liver inflammation

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Reviewing the function of macrophages in liver disease

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Molecular Mechanisms of Fibrosis in Cholestatic Liver Diseases and Regenerative Medicine-Based Therapies

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PPARα agonist ameliorates cholestatic liver injury by regulating hepatic macrophage homeostasis

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Macrophage heterogeneity in liver fibrosis

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STING promotes homeostatic maintenance of tissues and confers longevity with agingPreprint

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SPP1-mediated crosstalk between macrophage and fibroblasts promotes benign airway stenosis

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Organokine-Mediated Crosstalk: A Systems Biology Perspective on the Pathogenesis of MASLD—A Narrative Review

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Osteopontin: an indispensable component in common liver, pancreatic, and biliary related disease

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Macrophages make a difference in cholestatic liver diseases – but how?

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IL-22 supports long-term expansion of mouse and human hepatocytes

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Bile duct-associated macrophages enter the spotlight in inflammatory cholestatic liver disease

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Macrophages in Autoimmune Liver Diseases: From Immune Homeostasis to Precision-Targeted Therapy

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Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

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Single cell atlas decodes the molecular dynamics of scar repair after human rotator cuff tear

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The pan-PPAR agonist lanifibranor reduces portal pressure independent of fibrosis reduction through the splanchnic vasculature

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The pro-fibrogenic role of SPP1+ macrophages in medical implant fibrosis: mechanisms and therapeutic opportunities

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Stard1 promotes cholestatic liver injury and disease progression by sensitizing to bile acid hepatotoxicity

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Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGFβ1 expression

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Macrophage signaling associates with fibrogenic program activation in periductal fibroblasts in pediatric primary sclerosing cholangitis

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Targeting osteopontin to treat primary sclerosing cholangitis

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Single-cell RNA sequencing and functional analysis reveal the role of altered glycosylation levels of hepatic macrophages in liver cirrhosis

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Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression

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Deficiency of osteopontin in gut epithelial cells enhances intestinal integrity by promoting gut renewal through the JAK3/STAT4 pathway in acetaminophen (APAP)-induced acute liver injury

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Multi-omics characterization of healthy and PSC human liver – what we knew and what we have learned

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NicheSphere reveals Spp1⁺ macrophages as central hubs coordinating fibrotic remodeling in myeloproliferative neoplasmsPreprint

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Serum osteopontin levels predict short-term outcomes in patients with hepatitis B-related acute-on-chronic liver failure

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Additional file 3 of Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis

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Additional file 4 of Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis

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Additional file 1 of Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis

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Additional file 2 of Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis

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Loss of β-catenin in cholangiocytes promotes hepatocyte reprogramming and vascular remodeling during murine cholestasis

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Conserved Ductular Reaction Mechanisms in Biliary Atresia and Primary Sclerosing Cholangitis Derived From Single-Cell and Spatial Transcriptomics

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Peeling back the layers: Resident Kupffer cell plasticity shapes hepatic defense lines in tuberculosis granulomas

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The biliary tree: A new frontier in mucosal immunology?

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Can we cure primary biliary cholangitis?

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Interleukin-8–driven monocyte activation in primary sclerosing cholangitis: Insights from single-cell analysis and humanized immune system mice

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Label-Free Urinary Proteomics Uncovers Immune-Related Non-Invasive Biomarkers for Primary Biliary Cholangitis

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Multi-omics mapping of PSC genetic risk to a high TWAS-active JAML+ lipid-associated macrophage program: bridging single-cell heterogeneity, spatial fibrotic niches, and machine learning selection

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Context-Dependent Roles of Liver Macrophages in MASH

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Disrupted copper homeostasis promotes osteopontin-mediated hepatocyte–stellate cell crosstalk in Wilson disease

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Multidimensional regulation of hepatic macrophages in chronic liver disease: from metabolic reprogramming to intercellular and interorgan crosstalk

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Ductular reaction as a spatial fibrogenic niche: cholangiocyte–macrophage–fibroblast crosstalk in chronic liver disease

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Spatial organization of fibroblast subpopulations and niches across acute repair and chronic fibrotic remodeling of the human myocardiumPreprint

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NicheSphere reveals an Spp1-centered multicellular niche in myeloproliferative neoplasm-associated fibrosis

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SPP1+ macrophages in fibrosis

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Targeting osteopontin to treat primary sclerosing cholangitis

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Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis

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Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

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Macrophage signaling associates with fibrogenic program activation in periductal fibroblasts in pediatric primary sclerosing cholangitis

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