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Cited by 173Physical Activity and HealthBlood Pressure and Hypertension StudiesCardiovascular and exercise physiology

Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes

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Dempsey, Paddy C., Sacre, Julian W., Larsen, Robyn N., Straznicky, Nora E., Sethi, Parneet, Cohen, Neale D., Cerin, Ester, Lambert, Gavin W. +3 more·2016·Journal of Hypertension
DOI 10.1097/hjh.0000000000001101
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Abstract

OBJECTIVE: Prolonged sitting is increasingly recognized as a ubiquitous cardiometabolic risk factor, possibly distinct from lack of physical exercise. We examined whether interrupting prolonged sitting with brief bouts of light-intensity activity reduced blood pressure (BP) and plasma noradrenaline in type 2 diabetes (T2D). METHODS: In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men; mean ± SD; 62 ± 6 years) consumed standardized meals during 3 × 8 h conditions: uninterrupted sitting (SIT); sitting + half-hourly bouts of walking (3.2 km/h for 3-min) (light-intensity walking); and sitting + half-hourly bouts of simple resistance activities for 3 min (SRAs), each separated by 6-14 days washout. Resting seated BP was measured hourly (mean of three recordings, ≥20-min postactivity). Plasma noradrenaline was measured at 30-min intervals for the first hour after meals and hourly thereafter. RESULTS: Compared with SIT, mean resting SBP and DBP were significantly reduced (P < 0.001) for both light-intensity walking (mean ± SEM; -14 ± 1/-8 ± 1 mmHg) and SRA (-16 ± 1/-10 ± 1 mmHg), with a more pronounced effect for SRA (P < 0.05 versus light-intensity walking). Similarly, mean plasma noradrenaline was significantly reduced for both light-intensity walking (-0.3 ± 0.1 nmol/l) and SRA (-0.6 ± 0.1 nmol/l) versus SIT, with SRA lower than light-intensity walking (P < 0.05). Mean resting heart rate was lowered by light-intensity walking (-3 ± 1 bpm; P < 0.05), but not SRA (-1 ± 1 bpm). CONCLUSION: Interrupting prolonged sitting with brief bouts of light-intensity walking or SRA reduces resting BP and plasma noradrenaline in adults with T2D, with SRA being more effective. Given the ubiquity of sedentary behaviors and poor adherence to structured exercise, this approach may have important implications for BP management in patients with T2D.

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Authors
Dempsey, P. C., Sacre, J. W., Larsen, R. N., Straznicky, N. E., Sethi, P., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., & Dunstan, D. W.
Affiliations
Baker Heart and Diabetes Institute (AU)
Corresponding author
Dempsey, Paddy C.
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-12
Volume
34
Issue
12
Pages
2376-2382
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/hjh.0000000000001101
OpenAlex
W2515936183
Cited by
173
References
37
Citations by year
2026: 12 · 2025: 15 · 2024: 21 · 2023: 14 · 2022: 25 · 2021: 19 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 16 · 2016: 1 · 2014: 1
FWCI
13.40
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Journal of Hypertension (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion)
  • Apollo
Funders
  • American Heart Association
  • State Government of Victoria
  • Australian Research Council (FT140100085)
  • National Health and Medical Research Council (1081734)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
prolonged sitting, sedentary behavior, type 2 diabetes, resting blood pressure, plasma norepinephrine, resting heart rate, blood pressure control
MeSH terms
Aged, Blood Pressure, Diabetes Mellitus, Type 2, Female, Heart Rate, Humans, Male, Middle Aged, Norepinephrine, Obesity, Posture, Rest, Walking, Cross-Over Studies, Resistance Training

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