Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial

Peddie, Meredith C; Bone, Julia L; Rehrer, Nancy J; Skeaff, C Murray; Gray, Andrew R; Perry, Tracy L

doi:10.3945/ajcn.112.051763

Cited by 431Physical Activity and HealthDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial

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Peddie, Meredith C, Bone, Julia L, Rehrer, Nancy J, Skeaff, C Murray, Gray, Andrew R, Perry, Tracy L·2013·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.112.051763

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Abstract

Background Sedentary behavior is a risk factor for cardiometabolic disease. Regularly interrupting sedentary behavior with activity breaks may lower this risk.Objective We compared the effects of prolonged sitting, continuous physical activity combined with prolonged sitting, and regular activity breaks on postprandial metabolism.Design Seventy adults participated in a randomized crossover study. The prolonged sitting intervention involved sitting for 9 h, the physical activity intervention involved walking for 30 min and then sitting, and the regular-activity-break intervention involved walking for 1 min 40 s every 30 min. Participants consumed a meal-replacement beverage at 60, 240, and 420 min.Results The plasma incremental area under the curve (iAUC) for insulin differed between interventions (overall P < 0.001). Regular activity breaks lowered values by 866.7 IU · L(-1) · 9 h(-1) (95% CI: 506.0, 1227.5 IU · L(-1) · 9 h(-1); P < 0.001) when compared with prolonged sitting and by 542.0 IU · L(-1) · 9 h(-1) (95% CI: 179.9, 904.2 IU · L(-1) · 9 h(-1); P = 0.003) when compared with physical activity. Plasma glucose iAUC also differed between interventions (overall P < 0.001). Regular activity breaks lowered values by 18.9 mmol · L(-1) · 9 h(-1) (95% CI: 10.0, 28.0 mmol · L(-1) · 9 h(-1); P < 0.001) when compared with prolonged sitting and by 17.4 mmol · L(-1) · 9 h(-1) (95% CI: 8.4, 26.3 mmol · L(-1) · 9 h(-1); P < 0.001) when compared with physical activity. Plasma triglyceride iAUC differed between interventions (overall P = 0.023). Physical activity lowered values by 6.3 mmol · L(-1) · 9 h(-1) (95% CI: 1.8, 10.7 mmol · L(-1) · 9 h(-1); P = 0.006) when compared with regular activity breaks.Conclusion Regular activity breaks were more effective than continuous physical activity at decreasing postprandial glycemia and insulinemia in healthy, normal-weight adults. This trial was registered with the Australian New Zealand Clinical Trials registry as ACTRN12610000953033.

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Replacing SB by LIPA also had as strong an effect as replacing it with MVPA.
“In addition, replacing SB by LIPA also had as strong an effect as replacing it with MVPA (Table 4), as it has been observed experimentally [43–45].”
From Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach (2015) · cites this paper as [44]

Physical Activity and Public Health: Updated Recommendation for Adults from the American College of Sports Medicine and the American Heart Association
HASKELL, W. L., LEE, I.-M., PATE, R. R., POWELL, K. E., BLAIR, S. N., FRANKLIN, B. A., MACERA, C. A., HEATH, G. W., THOMPSON, P. D., & BAUMAN, A. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180616b27 · Cited by 4,616 · see citing works
Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
Nordestgaard, B. G., Benn, M., Schnohr, P., & Tybjærg-Hansen, A. (2007) · JAMA · doi:10.1001/jama.298.3.299 · Cited by 2,058 · see citing works
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
Bansal, S., Buring, J. E., Rifai, N., Mora, S., Sacks, F. M., & Ridker, P. M. (2007) · JAMA · doi:10.1001/jama.298.3.309 · Cited by 1,619 · see citing works
Breaks in Sedentary Time
Healy, G. N., Dunstan, D. W., Salmon, J., Cerin, E., Shaw, J. E., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-2046 · Cited by 1,465 · see citing works
Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06
Healy, G. N., Matthews, C. E., Dunstan, D. W., Winkler, E. A. H., & Owen, N. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq451 · Cited by 1,368 · see citing works
Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
Dunstan, D. W., Kingwell, B. A., Larsen, R., Healy, G. N., Cerin, E., Hamilton, M. T., Shaw, J. E., Bertovic, D. A., Zimmet, P. Z., Salmon, J., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1931 · Cited by 1,203 · see citing works
DECLINING RATES OF PHYSICAL ACTIVITY IN THE UNITED STATES: What Are the Contributors?
Brownson, R. C., Boehmer, T. K., & Luke, D. A. (2005) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.26.021304.144437 · Cited by 952 · see citing works
Television Viewing and Risk of Type 2 Diabetes, Cardiovascular Disease, and All-Cause Mortality: A Meta-analysis
Grøntved, A. (2011) · JAMA · doi:10.1001/jama.2011.812 · Cited by 873 · see citing works
Television Viewing Time and Mortality: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
Dunstan, D. W., Barr, E. L. M., Healy, G. N., Salmon, J., Shaw, J. E., Balkau, B., Magliano, D. J., Cameron, A. J., Zimmet, P. Z., & Owen, N. (2010) · Circulation · doi:10.1161/circulationaha.109.894824 · Cited by 825 · see citing works
Is Nondiabetic Hyperglycemia a Risk Factor for Cardiovascular Disease?: A Meta-analysis of Prospective Studies
Levitan, E. B., Song, Y., Ford, E. S., & Liu, S. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.19.2147 · Cited by 668 · see citing works
Amount of time spent in sedentary behaviors and cause-specific mortality in US adults
Matthews, C. E., George, S. M., Moore, S. C., Bowles, H. R., Blair, A., Park, Y., Troiano, R. P., Hollenbeck, A., & Schatzkin, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.019620 · Cited by 655 · see citing works
Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low‐intensity activity
Bey, L., & Hamilton, M. T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045591 · Cited by 509 · see citing works
Exercise-induced increase in muscle insulin sensitivity
Holloszy, J. O. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00123.2005 · Cited by 494 · see citing works
Postprandial plasma lipoprotein changes in human subjects of different ages.
Cohn, J. S., McNamara, J. R., Cohn, S. D., Ordovás, J. M., & Schaefer, E. J. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38520-5 · Cited by 448 · see citing works
A1C level and future risk of diabetes: a systematic review
Zhang, X., Gregg, E. W., Williamson, D. F., Barker, L. E., Thomas, W., Bullard, K. M., Imperatore, G., Williams, D. E., & Albright, A. L. (2010) · Diabetes Care · doi:10.2337/dc09-1939 · Cited by 422 · see citing works
Insulin and Risk of Cardiovascular Disease
Ruige, J. B., Assendelft, W. J., Dekker, J. M., Kostense, P. J., Heine, R. J., & Bouter, L. M. (1998) · Circulation · doi:10.1161/01.cir.97.10.996 · Cited by 393 · see citing works
Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake
Stephens, B. R., Granados, K. E., Zderic, T. W., Hamilton, M. T., & Braun, B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.08.014 · Cited by 233 · see citing works
Studies of Tissue Permeability
Holloszy, J. O., & NARAHARA, H. T. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97170-x · Cited by 222 · see citing works
Physical inactivity amplifies the sensitivity of skeletal muscle to the lipid-induced downregulation of lipoprotein lipase activity
Zderic, T. W., & Hamilton, M. T. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00925.2005 · Cited by 174 · see citing works
Moderate exercise, postprandial lipemia, and skeletal muscle lipoprotein lipase activity
Herd, S. L., Kiens, B., Boobis, L., & Hardman, A. E. (2001) · Metabolism · doi:10.1053/meta.2001.24199 · Cited by 152 · see citing works
Stability of plasma analytes after delayed separation of whole blood: implications for epidemiological studies
Clark, S., Youngman, L. D., Palmer, A., Parish, S., Peto, R., & Collins, R. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg023 · Cited by 142 · see citing works
The use of baseline covariates in crossover studies
Kenward, M. G., & Roger, J. (2009) · Biostatistics · doi:10.1093/biostatistics/kxp046 · Cited by 138 · see citing works
Role of local contractile activity and muscle fiber type on LPL regulation during exercise
Hamilton, M. T., Etienne, J., McClure, W. C., Pavey, B. S., & Holloway, A. K. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.6.e1016 · Cited by 132 · see citing works
Accumulating short bouts of brisk walking reduces postprandial plasma triacylglycerol concentrations and resting blood pressure in healthy young men
Miyashita, M., Burns, S. F., & Stensel, D. J. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26493 · Cited by 127 · see citing works
Fat as a fuel: emerging understanding of the adipose tissue–skeletal muscle axis
Frayn, K. N. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02128.x · Cited by 121 · see citing works
Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure
Magkos, F., Tsekouras, Y., Kavouras, S. A., Mittendorfer, B., & Sidossis, L. S. (2007) · Clinical Science · doi:10.1042/cs20070134 · Cited by 107 · see citing works
Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity
Bey, L., Akunuri, N., Zhao, P., Hoffman, E. P., Hamilton, D. G., & Hamilton, M. T. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00001.2002 · Cited by 106 · see citing works
Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk
Gerich (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s8216 · Cited by 101 · see citing works
Physical activity and postprandial lipidemia: Are energy expenditure and lipoprotein lipase activity the real modulators of the positive effect?
Peddie, M. C., Rehrer, N. J., & Perry, T. L. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.002 · Cited by 75 · see citing works
Self-citation
Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states
Gill, J. M. R., Herd, S. L., Vora, V., & Hardman, A. E. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0788-9 · Cited by 70 · see citing works
Exaggerated postprandial lipaemia and lower post-heparin lipoprotein lipase activity in middle-aged men
Jackson, K. G., KNAPPER-FRANCIS, J. M. E., Morgan, L., WEBB, D. H., Zampelas, A., & Williams, C. M. (2003) · Clinical Science · doi:10.1042/cs20030134 · Cited by 34 · see citing works
High Stability of Markers of Cardiovascular Risk in Blood Samples
Giltay, E. J., Geleijnse, J. M., Schouten, E. G., Katan, M., & Kromhout, D. (2003) · Clinical Chemistry · doi:10.1373/49.4.652 · Cited by 33 · see citing works
Impact of age and menopausal status on the postprandial triacylglycerol response in healthy women
Jackson, K. G., Abraham, E. C., Smith, A. M., Murray, P., O’Malley, B., Williams, C. M., & Minihane, A. M. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.06.030 · Cited by 29 · see citing works
Stability of insulin in normal whole blood.
Walters, E. J., Henley, R., & Barnes, I. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.1.224a · Cited by 14 · see citing works
Monitoring therapy with insulin in ketoacidotic patients by quantifying 3-hydroxybutyrate with a commercial kit.
Mercer, D., Losos, F. J., Mason, L. A., & Kessler, G. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.1.224 · Cited by 9 · see citing works

Flagged first, then by citations

1 of the 36 references couldn’t be matched to a known paper.

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Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis
Patterson, R., McNamara, E., Tainio, M., de Sá, T. H., Smith, A. D., Sharp, S. J., Edwards, P., Woodcock, J., Brage, S., & Wijndaele, K. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0380-1 · Cited by 1,423 · see citing works
Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach
Chastin, S. F. M., Palarea-Albaladejo, J., Dontje, M. L., & Skelton, D. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139984 · Cited by 1,034 · see citing works
Patterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults
Diaz, K. M., Howard, V. J., Hutto, B., Colabianchi, N., Vena, J. E., Safford, M. M., Blair, S. N., & Hooker, S. P. (2017) · Annals of Internal Medicine · doi:10.7326/m17-0212 · Cited by 533 · see citing works
Exercise and physical activity recommendations for people with cerebral palsy
Verschuren, O. W., Peterson, M. D., Balemans, A. C. J., & Hurvitz, E. A. (2016) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13053 · Cited by 440 · see citing works
Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities
Dempsey, P. C., Larsen, R. N., Sethi, P., Sacre, J. W., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2336 · Cited by 405 · see citing works
Physiology of sedentary behavior
Pinto, A. J., Bergouignan, A., Dempsey, P. C., Roschel, H., Owen, N. G., Gualano, B., & Dunstan, D. W. (2023) · Physiological Reviews · doi:10.1152/physrev.00022.2022 · Cited by 400 · see citing works
Meta‐analysis of the relationship between breaks in sedentary behavior and cardiometabolic health
Chastin, S. F. M., Egerton, T., Leask, C., & Stamatakis, E. (2015) · Obesity · doi:10.1002/oby.21180 · Cited by 363 · see citing works
Breaking up prolonged sitting with light-intensity walking improves postprandial glycemia, but breaking up sitting with standing does not
Bailey, D. P., & Locke, C. D. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.03.008 · Cited by 358 · see citing works
Effects of interrupting prolonged sitting with physical activity breaks on blood glucose, insulin and triacylglycerol measures: A systematic review and meta-analysis
Loh, R., Stamatakis, E., Folkerts, D., Allgrove, J. E., & Moir, H. J. (2020) · Sports Medicine · doi:10.1007/s40279-019-01183-w · Cited by 326 · see citing works
Interventions with potential to reduce sedentary time in adults: systematic review and meta-analysis
Martin, A., Fitzsimons, C., Jepson, R., Saunders, D. H., van der Ploeg, H. P., Teixeira, P. J., Gray, C. M., & Mutrie, N. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-094524 · Cited by 326 · see citing works
The Effects of Breaking up Prolonged Sitting Time
Benatti, F. B., & Ried‐Larsen, M. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000654 · Cited by 312 · see citing works
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Objectively measured sedentary behaviour and health and development in children and adolescents: systematic review and meta‐analysis
Cliff, D. P., Hesketh, K. D., Vella, S. A., Hinkley, T., Tsiros, M. D., Ridgers, N. D., Carver, A., Veitch, J., Parrish, A., Hardy, L. L., et al. (2016) · Obesity Reviews · doi:10.1111/obr.12371 · Cited by 306 · see citing works
Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial
Edwardson, C. L., Yates, T. E., Biddle, S., Davies, M. J., Dunstan, D. W., Esliger, D., Gray, L. J., Jackson, B., O'Connell, S. E., Waheed, G., et al. (2018) · BMJ · doi:10.1136/bmj.k3870 · Cited by 272 · see citing works
Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms
Carter, S. E., Hartman, Y., Holder, S. M., Thijssen, D. H. J., & Hopkins, N. D. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000106 · Cited by 271 · see citing works
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Alternating Bouts of Sitting and Standing Attenuate Postprandial Glucose Responses
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Regular walking breaks prevent the decline in cerebral blood flow associated with prolonged sitting
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Patterns of Sedentary Behavior in US Middle-Age and Older Adults: The REGARDS Study
DIAZ, K. M., HOWARD, V. J., HUTTO, B., COLABIANCHI, N., VENA, J. E., BLAIR, S. N., & HOOKER, S. P. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000792 · Cited by 170 · see citing works
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“Experimental studies have shown that by comparison with sitting that has been interrupted with small amounts of activity, sitting continuously for prolonged periods has acute detrimental effects on blood pressure and lipid metabolism [10–12] and on postprandial glucose control [13,14], with some effects persisting for…”
Background
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Graves, L., Murphy, R., Shepherd, S. O., Cabot, J., & Hopkins, N. D. (2015) · BMC Public Health · doi:10.1186/s12889-015-2469-8 · Cited by 168 · see citing works
Revenge of the “sit” II: does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity?
Voss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164 · see citing works
Sitting Less and Moving More: Improved Glycaemic Control for Type 2 Diabetes Prevention and Management
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Sedentary behaviour is a key determinant of metabolic inflexibility
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Take a Stand!–a multi-component intervention aimed at reducing sitting time among office workers–a cluster randomized trial
Danquah, I. H., Kloster, S., Holtermann, A., Aadahl, M., Bauman, A. E., Ersbøll, A. K., & Tolstrup, J. S. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw009 · Cited by 131 · see citing works
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Henson, J. J., Dunstan, D. W., Davies, M. J., & Yates, T. E. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2759 · Cited by 113 · see citing works
Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?
Pinto, A. J., Roschel, H., Pinto, A. L. D. S., Lima, F. R., Pereira, R. M. R., Silva, C. A., Bonfá, E., & Gualano, B. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.001 · Cited by 112 · see citing works
The association between time spent in sedentary behaviors and blood pressure: A systematic review and meta-analysis
Lee, P. H., & Wong, F. K. Y. (2015) · Sports Medicine · doi:10.1007/s40279-015-0322-y · Cited by 102 · see citing works
What is the metabolic and energy cost of sitting, standing and sit/stand transitions?
Júdice, P. B., Hamilton, M. T., Sardinha, L. B., Zderic, T. W., & Silva, A. M. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3279-5 · Cited by 104 · see citing works
Biomarkers associated with sedentary behaviour in older adults: A systematic review
Wirth, K., Klenk, J., Brefka, S., Dallmeier, D., Kathrin, F., Figuls, M. R. I., Tully, M. A., Giné‐Garriga, M., Caserotti, P., Salvà, A., et al. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.002 · Cited by 102 · see citing works
The efficacy of motivational counselling and SMS reminders on daily sitting time in patients with rheumatoid arthritis: a randomised controlled trial
Thomsen, T., Aadahl, M., Beyer, N., Hetland, M. L., Løppenthin, K. B., Midtgaard, J., Christensen, R., Østergaard, M., Jennum, P., & Esbensen, B. A. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210953 · Cited by 100 · see citing works
Intermittent walking, but not standing, improves postprandial insulin and glucose relative to sustained sitting: A randomised cross-over study in inactive middle-aged men
Pulsford, R. M., Blackwell, J. R., Hillsdon, M. M., & Kos, K. (2016) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2016.08.012 · Cited by 103 · see citing works
Sedentary behavior patterns and the risk of non-communicable diseases and all-cause mortality: A systematic review and meta-analysis
Wu, J., Fu, Y., Chen, D., Zhang, H., Xue, E., Shao, J., Tang, L., Zhao, B., Lai, C., & Ye, Z. (2023) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2023.104563 · Cited by 110 · see citing works
From Sedentary Time to Sedentary Patterns: Accelerometer Data Reduction Decisions in Youth
Chinapaw, M. J. M., de Niet, M., Verloigne, M., Bourdeaudhuij, I. D., Brug, J., & Altenburg, T. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111205 · Cited by 100 · see citing works
The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults
Altenburg, T. M., Rotteveel, J., Dunstan, D. W., Salmon, J., & Chinapaw, M. J. M. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00662.2013 · Cited by 99 · see citing works
What Is the Effect on Obesity Indicators from Replacing Prolonged Sedentary Time with Brief Sedentary Bouts, Standing and Different Types of Physical Activity during Working Days? A Cross-Sectional Accelerometer-Based Study among Blue-Collar Workers
Gupta, N., Heiden, M., Aadahl, M., Korshøj, M., Jørgensen, M. B., & Holtermann, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154935 · Cited by 97 · see citing works
Gender and Age Differences in Hourly and Daily Patterns of Sedentary Time in Older Adults Living in Retirement Communities
Bellettiere, J., Carlson, J., Rosenberg, D. E., Singhania, A., Natarajan, L., Berardi, V., LaCroix, A. Z., Sears, D. D., Moran, K., Crist, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136161 · Cited by 92 · see citing works
Effectiveness of intervention strategies exclusively targeting reductions in children’s sedentary time: a systematic review of the literature
Altenburg, T. M., Holthe, J. K.-V., & Chinapaw, M. J. M. (2016) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-016-0387-5 · Cited by 88 · see citing works
Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults
Duvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., Giesbrecht, T., Moonen‐Kornips, E., Hulsbosch, M. M., Willems, P. J. B., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00353 · Cited by 89 · see citing works
Accelerometer‐Derived Pattern of Sedentary and Physical Activity Time in Persons with Mobility Disability: National Health and Nutrition Examination Survey 2003 to 2006
Manns, P. J., Ezeugwu, V. E., Armijo-Olivo, S. L., Vallance, J. K., & Healy, G. N. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13490 · Cited by 86 · see citing works
Efficacy of the ‘Stand and Move at Work’ Multicomponent Workplace Intervention to Reduce Sedentary Time and Improve Cardiometabolic Risk: A Group Randomized Clinical Trial
Pereira, M. A., Mullane, S. L., Toledo, M. J. L., Larouche, M. L., Rydell, S. A., Vuong, B., Feltes, L. H., Mitchell, N. R., de Brito, J. N., Hasanaj, K., et al. (2019) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-01033-3 · Cited by 87 · see citing works
Breaking up of prolonged sitting over three days sustains, but does not enhance, lowering of postprandial plasma glucose and insulin in overweight and obese adults
Larsen, R. N., Kingwell, B. A., Robinson, C., Hammond, L. J., Cerin, E., Shaw, J. E., Healy, G. N., Hamilton, M. T., Owen, N. G., & Dunstan, D. W. (2015) · Clinical Science · doi:10.1042/cs20140790 · Cited by 87 · see citing works
Sitting time and physical activity after stroke: physical ability is only part of the story
English, C., Healy, G. N., Coates, A. M., Lewis, L. K., Olds, T., & Bernhardt, J. A. (2015) · Topics in Stroke Rehabilitation · doi:10.1179/1945511915y.0000000009 · Cited by 83 · see citing works
Workplace interventions for increasing standing or walking for decreasing musculoskeletal symptoms in sedentary workers
Parry, S. P., Coenen, P., Shrestha, N., O’Sullivan, P., Maher, C. G., & Straker, L. M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012487.pub2 · Cited by 82 · see citing works
Motivational Counseling to Reduce Sitting Time
Aadahl, M., Linneberg, A. R., Møller, T. C., Rosenørn, S., Dunstan, D. W., Witte, D. R., & Jørgensen, T. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.06.020 · Cited by 77 · see citing works
Breaks in Sitting Time
Bhammar, D. M., Sawyer, B. J., Tucker, W. J., & Gaesser, G. A. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001315 · Cited by 79 · see citing works
Prolonged, uninterrupted sedentary behavior and glycemic biomarkers among US Hispanic/Latino adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Diaz, K. M., Goldsmith, J., Greenlee, H., Strizich, G., Qi, Q., Mossavar-Rahmani, Y., Vidot, D., Buelna, C., Brintz, C. E., Elfassy, T., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026858 · Cited by 64 · see citing works
Association of Accelerometer-Measured Sedentary Time and Physical Activity With Risk of Stroke Among US Adults
Hooker, S. P., Diaz, K. M., Blair, S. N., Colabianchi, N., Hutto, B., McDonnell, M. N., Vena, J. E., & Howard, V. J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.15385 · Cited by 79 · see citing works
Metabolic Effect of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks
Rafiei, H., Omidian, K., Myette‐Côté, É., & Little, J. P. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002431 · Cited by 73 · see citing works
Sedentary Behavior and Body Weight and Composition in Adults: A Systematic Review and Meta-analysis of Prospective Studies
Campbell, S., Brosnan, B. J., Chu, A. K. Y., Skeaff, C. M., Rehrer, N. J., Perry, T., & Peddie, M. C. (2017) · Sports Medicine · doi:10.1007/s40279-017-0828-6 · Cited by 73 · see citing works
Self-citation
The Effectiveness of Sedentary Behaviour Reduction Workplace Interventions on Cardiometabolic Risk Markers: A Systematic Review
Brierley, M. L., Chater, A., Smith, L. R., & Bailey, D. P. (2019) · Sports Medicine · doi:10.1007/s40279-019-01168-9 · Cited by 69 · see citing works
The effects of prolonged sitting, prolonged standing, and activity breaks on vascular function, and postprandial glucose and insulin responses: A randomised crossover trial
Peddie, M. C., Kessell, C., Bergen, T., Gibbons, T. D., Campbell, H. A., Cotter, J. D., Rehrer, N. J., & Thomas, K. N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244841 · Cited by 71 · see citing works
Self-citation
Activity trackers implement different behavior change techniques for activity, sleep, and sedentary behaviors
Duncan, M., Murawski, B., Short, C. E., Rebar, A. L., Schoeppe, S., Alley, S., Vandelanotte, C., & Kirwan, M. (2017) · Interactive Journal of Medical Research · doi:10.2196/ijmr.6685 · Cited by 68 · see citing works
Bouts and breaks in children's sedentary time: currently used operational definitions and recommendations for future research
Altenburg, T. M., & Chinapaw, M. J. M. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.04.019 · Cited by 67 · see citing works
Workplace building design and office‐based workers' activity: a study of a natural experiment
Jancey, J. M., McGann, S., Creagh, R., Blackford, K., Howat, P. A., & Tye, M. (2015) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.12464 · Cited by 66 · see citing works
Regular activity breaks combined with physical activity improve postprandial plasma triglyceride, nonesterified fatty acid, and insulin responses in healthy, normal weight adults: A randomized crossover trial
Homer, A. R., Fenemor, S. P., Perry, T., Rehrer, N. J., Cameron, C., Skeaff, C. M., & Peddie, M. C. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.06.007 · Cited by 64 · see citing works
Self-citation
Effect of different walking break strategies on superficial femoral artery endothelial function
Carter, S. E., Draijer, R., Holder, S. M., Brown, L., Thijssen, D. H. J., & Hopkins, N. D. (2019) · Physiological Reports · doi:10.14814/phy2.14190 · Cited by 63 · see citing works
The independent and combined effects of exercise training and reducing sedentary behavior on cardiometabolic risk factors
Keadle, S. K., Lyden, K. A., STAUDENMAYER, J. W., Hickey, A., Viskochil, R. H., Braun, B., & Freedson, P. S. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0379 · Cited by 65 · see citing works
Improving Cardiometabolic Health with Diet, Physical Activity, and Breaking Up Sitting: What about Sleep?
Vincent, G. E., Jay, S. M., Sargent, C., Vandelanotte, C., Ridgers, N. D., & Ferguson, S. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00865 · Cited by 61 · see citing works
Volumes and bouts of sedentary behavior and physical activity: Associations with cardiometabolic health in obese children
Cliff, D. P., Jones, R. A., Burrows, T. L., Morgan, P. J., Collins, C. E., Baur, L. A., & Okely, A. D. (2014) · Obesity · doi:10.1002/oby.20698 · Cited by 61 · see citing works
Associations of reallocating sitting time into standing or stepping with glucose, insulin and insulin sensitivity: A cross-sectional analysis of adults at risk of type 2 diabetes
Edwardson, C. L., Henson, J., Bodicoat, D. H., Bakrania, K., Khunti, K., Davies, M. J., & Yates, T. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014267 · Cited by 59 · see citing works
Frequency of Breaks in Sedentary Time and Postprandial Metabolic Responses
HAWARI, N. S. A., Al-Shayji, I. A. R., Wilson, J., & Gill, J. M. R. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001034 · Cited by 60 · see citing works
Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose
Crespo, N. C., Mullane, S. L., Zeigler, Z., Buman, M. P., & Gaesser, G. A. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001062 · Cited by 57 · see citing works
Comparing the effects of two different break strategies on occupational sedentary behavior in a real world setting: A randomized trial
Mailey, E. L., Rosenkranz, S. K., Casey, K., & Swank, A. (2016) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2016.08.010 · Cited by 57 · see citing works
Wearable Technology To Reduce Sedentary Behavior And CVD Risk In Older Adults: A Pilot Randomized Clinical Trial
Roberts, L. M., Jaeger, B. C., Baptista, L. C. P., Harper, S. A., Gardner, A. K., Jackson, E. A., Pekmezi, D., Sandesara, B. D., Manini, T. M., Anton, S. D., et al. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s222655 · Cited by 56 · see citing works
Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial
Duran, A. T., Friel, C. P., Serafini, M. A., Ensari, I., Cheung, Y. K., & Diaz, K. M. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003109 · Cited by 56 · see citing works
Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial
Kerr, J., Crist, K., Vital, D. G., Dillon, L. W., Aden, S. A., Trivedi, M., Castellanos, L. R., Godbole, S. V., Li, H., Allison, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188544 · Cited by 55 · see citing works
Affective Responses to Intermittent Physical Activity in Healthy Weight and Overweight/Obese Elementary School-Age Children
Nagy, M. R., O’Sullivan, M. P., Block, S. S., Tooley, T. R., Robinson, L. E., Colabianchi, N., & Hasson, R. E. (2017) · Journal of Physical Activity and Health · doi:10.1123/jpah.2016-0552 · Cited by 54 · see citing works
Revisiting the Role of Exercise Countermeasure on the Regulation of Energy Balance During Space Flight
Laurens, C., Simon, C., Vernikos-Danellis, J., Gauquelin‐Koch, G., Blanc, S., & Bergouignan, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00321 · Cited by 53 · see citing works
Effects of interrupting prolonged sitting on postprandial glycemia and insulin responses: A network meta-analysis
Quan, M., Xun, P., Hua, W., Wang, J., Cheng, W., Cao, M., Zhou, T., Huang, T., Gao, Z., & Chen, P. (2020) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.12.006 · Cited by 54 · see citing works
Workplace interventions for increasing standing or walking for decreasing musculoskeletal symptoms in sedentary workers
Parry, S. P., Coenen, P., O’Sullivan, P., Maher, C. G., & Straker, L. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012487 · Cited by 52 · see citing works
Effects of breaking up sitting on adolescents’ postprandial glucose after consuming meals varying in energy: a cross-over randomised trial
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Fitness Moderates Glycemic Responses to Sitting and Light Activity Breaks
McCarthy, M., Edwardson, C. L., Davies, M. J., Henson, J. J., Bodicoat, D. H., Khunti, K. K., Dunstan, D. W., King, J. A., & Yates, T. E. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001338 · Cited by 52 · see citing works
Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults
Dogra, S., Wolf, M., Jeffrey, M. P., Foley, R. C. A., Logan-Sprenger, H. M., Jones-Taggart, H., & Green-Johnson, J. M. (2019) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-019-0138-4 · Cited by 51 · see citing works
Should we target increased physical activity or less sedentary behavior in the battle against cardiovascular disease risk development?
Katzmarzyk, P. T., Ross, R., Blair, S. N., & Després, J. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.07.010 · Cited by 53 · see citing works
Occurrence and duration of various operational definitions of sedentary bouts and cross-sectional associations with cardiometabolic health indicators: The ENERGY-project
Altenburg, T. M., de Niet, M., Verloigne, M., Bourdeaudhuij, I. D., Androutsos, O., Μanios, Y., Kovacs, E., Bringolf‐Isler, B., Brug, J., & Chinapaw, M. J. M. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.12.015 · Cited by 49 · see citing works
Top 10 Research Questions Related to Physical Activity and Multiple Sclerosis
Motl, R. W., Learmonth, Y. C., Pilutti, L. A., Gappmaier, E., & Coote, S. B. (2015) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2015.1023099 · Cited by 49 · see citing works
Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
Swindell, N. J., Mackintosh, K. A., McNarry, M. A., Stephens, J. W., Sluik, D., Fogelholm, M., Drummen, M., Macdonald, I. A., Martínez, J. A., Handjieva‐Darlenska, T., et al. (2017) · Diabetes Care · doi:10.2337/dc17-1057 · Cited by 48 · see citing works
Exercise snacks and physical fitness in sedentary populations
Wang, T., Laher, I., & Li, S. (2024) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2024.02.006 · Cited by 48 · see citing works
The descriptive epidemiology of daily sitting time as a sedentary behavior in multiple sclerosis
Hubbard, E. A., Motl, R. W., & Manns, P. J. (2015) · Disability and health journal · doi:10.1016/j.dhjo.2015.06.003 · Cited by 49 · see citing works
Device-Measured Sedentary Behavior Patterns in Office-Based University Employees
Keown, M. K., Skeaff, C. M., Perry, T., Haszard, J. J., & Peddie, M. C. (2018) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001467 · Cited by 48 · see citing works
Self-citation
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Simpson, D. B., Breslin, M. C., Cumming, T. B., de Zoete, S., Gall, S., Schmidt, M. W., English, C., & Callisaya, M. L. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2018.04.012 · Cited by 47 · see citing works
Muscle Activation and Energy-Requirements for Varying Postures in Children and Adolescents with Cerebral Palsy
Verschuren, O. W., Peterson, M. D., Leferink, S., & Darrah, J. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.07.027 · Cited by 46 · see citing works
Muscle Inactivity Is Adversely Associated with Biomarkers in Physically Active Adults
Pesola, A. J., Laukkanen, A., Tikkanen, O., Sipilä, S., Kainulainen, H., & Finni, T. J. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000527 · Cited by 45 · see citing works
Sedentary behaviour and cardiometabolic health: Integrating the potential underlying molecular health aspects
Franssen, W. M. A., Nieste, I., Verboven, K., & Eijnde, B. O. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156320 · Cited by 54 · see citing works
Exercise Strategies to Optimize Glycemic Control in Type 2 Diabetes: A Continuing Glucose Monitoring Perspective
van Dijk, J., & van Loon, L. J. C. (2015) · Diabetes Spectrum · doi:10.2337/diaspect.28.1.24 · Cited by 47 · see citing works
Standing Breaks in Lectures Improve University Students’ Self-Perceived Physical, Mental, and Cognitive Condition
Paulus, M., Kunkel, J., Schmidt, S. C. E., Bachert, P., Wäsche, H., Neumann, R., & Woll, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18084204 · Cited by 45 · see citing works

Postprandial glucose and insulin response to regular activity breaks in comparison to prolonged sitting: the effect of physical activity the previous day
Homer, A. R. (2016) · Otago University Research Archive (University of Otago)
The Combined Effects Of Regular Activity Breaks And Physical Activity On Postprandial Metabolism
Peddie, M. C., Homer, A. R., Fenemore, S. P., Cameron, C., Skeaff, M., Rehrer, N. J., & Perry, T. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000517262.11239.26
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Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
Dunstan, D. W., Kingwell, B. A., Larsen, R., Healy, G. N., Cerin, E., Hamilton, M. T., Shaw, J. E., Bertovic, D. A., Zimmet, P. Z., Salmon, J., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1931 · Cited by 1,203 · see citing works
The Acute Metabolic Effects Of 'Breaking-up' Prolonged Sitting In Adults
Dunstan, D. W., Larsen, R. N., Healy, G. N., Kingwell, B. A., Cerin, E., Salmon, J., Shaw, J. E., Zimmet, P., Hamilton, M. T., & Owen, N. G. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000401490.53685.c7 · Cited by 1 · see citing works
The Acute Effects of Interrupting Prolonged Sitting With Regular Activity Breaks on Postprandial Glucose and Insulin in Adults: A Systematic Review and Meta‐Analysis
Gale, J. T., Martin, H., Haszard, J. J., & Peddie, M. C. (2026) · Obesity Reviews · doi:10.1111/obr.70152 · Cited by 8 · see citing works
Self-citation

Authors: Peddie, M. C., Bone, J. L., Rehrer, N. J., Skeaff, C. M., Gray, A. R., & Perry, T. L.
Affiliations: University of Otago (NZ)
ORCID: Peddie, Meredith C
Rehrer, Nancy J
Gray, Andrew R
Perry, Tracy L
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2013-08
Volume: 98
Issue: 2
Pages: 358-366
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.112.051763
OpenAlex: W2118900499
Cited by: 431
References: 36
Citations by year: 2026: 21 · 2025: 15 · 2024: 18 · 2023: 22 · 2022: 28 · 2021: 40 · 2020: 37 · 2019: 42 · 2018: 42 · 2017: 61 · 2016: 40 · 2015: 35 · 2014: 27 · 2013: 3
FWCI: 24.31
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3490 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: sedentary behavior, prolonged sitting, postprandial blood glucose, active breaks, walking breaks, physical activity, insulin response, plasma glucose, plasma triglycerides, cardiometabolic risk, postprandial lipemia, postprandial insulin response, postprandial glucose response, postprandial triglycerides
MeSH terms: Adult, Beverages, Blood Glucose, Cardiovascular Diseases, Diet, Female, Humans, Insulin, Male, New Zealand, Risk Factors, Time Factors, Triglycerides, Exercise, Body Mass Index, Walking, Cross-Over Studies, Postprandial Period, Area Under Curve, Young Adult, Sedentary Behavior

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Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial

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