Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 106

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Defining anabolic resistance: implications for delivery of clinical care nutrition

Morton, Robert W., Traylor, Daniel A., Weijs, Peter J.M., Phillips, Stuart M.·2018·Current Opinion in Critical Care
DOI 10.1097/mcc.0000000000000488
Open this paper in CoChat — free account

Abstract

Purpose of review: Skeletal muscle mass with aging, during critical care, and following critical care is a determinant of quality of life and survival. In this review, we discuss the mechanisms that underpin skeletal muscle atrophy and recommendations to offset skeletal muscle atrophy with aging and during, as well as following, critical care. Recent findings: Anabolic resistance is responsible, in part, for skeletal muscle atrophy with aging, muscle disuse, and during disease states. Anabolic resistance describes the reduced stimulation of muscle protein synthesis to a given dose of protein/amino acids and contributes to declines in skeletal muscle mass. Physical inactivity induces: anabolic resistance (that is likely exacerbated with aging), insulin resistance, systemic inflammation, decreased satellite cell content, and decreased capillary density. Critical illness results in rapid skeletal muscle atrophy that is a result of both anabolic resistance and enhanced skeletal muscle breakdown. Summary: Insofar as atrophic loss of skeletal muscle mass is concerned, anabolic resistance is a principal determinant of age-induced losses and appears to be a contributor to critical illness-induced skeletal muscle atrophy. Older individuals should perform exercise using both heavy and light loads three times per week, ingest at least 1.2 g of protein/kg/day, evenly distribute their meals into protein boluses of 0.40 g/kg, and consume protein within 2 h of retiring for sleep. During critical care, early, frequent, and multimodal physical therapies in combination with early, enteral, hypocaloric energy (∼10–15 kcal/kg/day), and high-protein (>1.2 g/kg/day) provision is recommended.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/mcc.0000000000000488

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 15 references

Research works printed but not linked: 54

  1. Farsijani, 2016, Relation between mealtime distribution of protein intake and lean mass loss in free-living older adults of the NuAge study, Am J Clin Nutr, 104, 694, 10.3945/ajcn.116.130716 · DOI · Paper page
  2. Puthucheary, 2013, Acute skeletal muscle wasting in critical illness, JAMA, 310, 1591, 10.1001/jama.2013.278481 · DOI · Paper page
  3. MacDonald, 2015, Habitual myofibrillar protein synthesis is normal in patients with upper GI cancer cachexia, Clin Cancer Res, 21, 1734, 10.1158/1078-0432.CCR-14-2004 · DOI
  4. Metter, 2002, Skeletal muscle strength as a predictor of all-cause mortality in healthy men, J Gerontol A Biol Sci Med Sci, 57, B359, 10.1093/gerona/57.10.B359 · DOI · Paper page
  5. Fantin, 2007, Longitudinal body composition changes in old men and women: interraltionships with worsening disability, J Gerontol A Biol Sci Med Sci, 62, 1375, 10.1093/gerona/62.12.1375 · DOI
  6. Mueller, 2016, Can sarcopenia quantified by ultrasound of the rectus femoris muscle predict adverse outcome of surgical intensive care unit patients as well as frailty? A prospective, observational cohort study, Ann Surg, 264, 1116, 10.1097/SLA.0000000000001546 · DOI
  7. Phillips, 2017, Physiological adaptations to resistance exercise as a function of age, JCI Insight, 10.1172/jci.insight.95581 · DOI
  8. Mitchell, 2017, Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men, Clin Nutr, 36, 1573, 10.1016/j.clnu.2016.09.031 · DOI
  9. Moore, 2015, Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men, J Gerontol A Biol Sci Med Sci, 70, 57, 10.1093/gerona/glu103 · DOI · Paper page
  10. Breen, 2013, Two weeks of reduced activity decreases leg lean mass and induces ‘anabolic resistance’ of myofibrillar protein synthesis in healthy elderly, J Clin Endocrinol Metab, 98, 2604, 10.1210/jc.2013-1502 · DOI · Paper page
  11. Tanner, 2015, Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation, J Physiol, 593, 4259, 10.1113/JP270699 · DOI · Paper page
  12. Liebau, 2015, Effect of initiating enteral protein feeding on whole-body protein turnover in critically ill patients, Am J Clin Nutr, 101, 549, 10.3945/ajcn.114.091934 · DOI
  13. van Dijk, 2015, Effects of oral meal feeding on whole body protein breakdown and protein synthesis in cachectic pancreatic cancer patients, J Cachexia Sarcopenia Muscle, 6, 212, 10.1002/jcsm.12029 · DOI
  14. Sundstrom Rehal, 2017, A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 h in critically ill patients, Crit Care, 21, 298, 10.1186/s13054-017-1892-x · DOI
  15. Berg, 2013, Whole body protein kinetics during hypocaloric and normocaloric feeding in critically ill patients, Crit Care, 17, R158, 10.1186/cc12837 · DOI
  16. Liebau, 2015, Short-term amino acid infusion improves protein balance in critically ill patients, Crit Care, 19, 106, 10.1186/s13054-015-0844-6 · DOI
  17. Arentson-Lantz, 19852016, Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults, J Appl Physiol (1985), 120, 965, 10.1152/japplphysiol.00799.2015 · DOI · Paper page
  18. Symons, 2009, Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity, J Appl Physiol (1985), 107, 34, 10.1152/japplphysiol.91137.2008 · DOI · Paper page
  19. McGlory, 2017, Failed recovery of glycemic control and myofibrillar protein synthesis with two weeks of physical inactivity in overweight, prediabetic older adults, J Gerontol A Biol Sci Med Sci
  20. Rodriguez-Acelas, 2017, Risk factors for healthcare-associated infection in hospitalized adults: systematic review and meta-analysis, Am J Infect Control, 45, e149, 10.1016/j.ajic.2017.08.016 · DOI
  21. Latronico, 2017, The ICM research agenda on intensive care unit-acquired weakness, Intensive Care Med, 43, 1270, 10.1007/s00134-017-4757-5 · DOI · Paper page
  22. Ali Abdelhamid, 2016, Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis, Crit Care, 20, 301, 10.1186/s13054-016-1471-6 · DOI
  23. Klaude, 2012, Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis, Clin Sci (Lond), 122, 133, 10.1042/CS20110233 · DOI
  24. Dickerson, 2015, Influence of aging on nitrogen accretion during critical illness, JPEN J Parenter Enteral Nutr, 39, 282, 10.1177/0148607113506939 · DOI
  25. Rooyackers, 2015, Whole body protein turnover in critically ill patients with multiple organ failure, Clin Nutr, 34, 95, 10.1016/j.clnu.2014.01.020 · DOI · Paper page
  26. Engelen, 2015, High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer, Ann Oncol, 26, 1960, 10.1093/annonc/mdv271 · DOI
  27. Reidy, 2017, Aging-related effects of bed rest followed by eccentric exercise rehabilitation on skeletal muscle macrophages and insulin sensitivity, Exp Gerontol
  28. Beals, 2016, Anabolic sensitivity of postprandial muscle protein synthesis to the ingestion of a protein-dense food is reduced in overweight and obese young adults, Am J Clin Nutr, 104, 1014, 10.3945/ajcn.116.130385 · DOI · Paper page
  29. Fougere, 2017, Chronic inflammation: accelerator of biological aging, J Gerontol A Biol Sci Med Sci, 72, 1218, 10.1093/gerona/glw240 · DOI
  30. Mikkelsen, 2015, Preserved skeletal muscle protein anabolic response to acute exercise and protein intake in well treated rheumatoid arthritis patients, Arthritis Res Ther, 17, 271, 10.1186/s13075-015-0758-3 · DOI
  31. Dos Santos, 2016, Mechanisms of chronic muscle wasting and dysfunction after an intensive care unit stay. a pilot study, Am J Respir Crit Care Med, 194, 821, 10.1164/rccm.201512-2344OC · DOI · Paper page
  32. Nederveen, 2016, Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men, J Cachexia Sarcopenia Muscle, 7, 547, 10.1002/jcsm.12105 · DOI
  33. Verdijk, 2016, Resistance training increases skeletal muscle capillarization in healthy older men, Med Sci Sports Exerc, 48, 2157, 10.1249/MSS.0000000000001019 · DOI
  34. Fry, 2016, Satellite cell activation and apoptosis in skeletal muscle from severely burned children, J Physiol, 594, 5223, 10.1113/JP272520 · DOI
  35. Snijders, 2017, Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans, Physiol Rep, 5, 10.14814/phy2.13278 · DOI
  36. Snijders, 2017, Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men, J Cachexia Sarcopenia Muscle, 8, 267, 10.1002/jcsm.12137 · DOI
  37. Wilkinson, 2017, Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women, Clin Nutr
  38. Jonker, 2017, Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults, Metabolism, 69, 120, 10.1016/j.metabol.2016.12.010 · DOI
  39. Di Girolamo, 2017, Intermittent vs. continuous enteral feeding to prevent catabolism in acutely ill adult and pediatric patients, Curr Opin Clin Nutr Metab Care, 20, 390, 10.1097/MCO.0000000000000397 · DOI
  40. Arends, 2017, ESPEN guidelines on nutrition in cancer patients, Clin Nutr, 36, 11, 10.1016/j.clnu.2016.07.015 · DOI · Paper page
  41. Rugeles, 2017, How many nonprotein calories does a critically ill patient require? A case for hypocaloric nutrition in the critically ill patient, Nutr Clin Pract, 32, S72, 10.1177/0884533617693608 · DOI
  42. Compher, 2017, Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter, multinational observational study, Crit Care Med, 45, 156, 10.1097/CCM.0000000000002083 · DOI · Paper page
  43. Reintam Blaser, 2017, Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines, Intensive Care Med, 43, 380, 10.1007/s00134-016-4665-0 · DOI · Paper page
  44. Weijs, 2017, Protein nutrition and exercise survival kit for critically ill, Curr Opin Crit Care, 23, 279, 10.1097/MCC.0000000000000425 · DOI
  45. Holwerda, 2016, Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men, J Nutr, 146, 1307, 10.3945/jn.116.230086 · DOI · Paper page
  46. Stamatakis, 2017, Does strength promoting exercise confer unique health benefits? A pooled analysis of eleven population cohorts with all-cause, cancer, and cardiovascular mortality endpoints, Am J Epidemiol
  47. Tipping, 2017, The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review, Intensive Care Med, 43, 171, 10.1007/s00134-016-4612-0 · DOI · Paper page
  48. Laurent, 2016, Systematic review of early exercise in intensive care: a qualitative approach, Anaesth Crit Care Pain Med, 35, 133, 10.1016/j.accpm.2015.06.014 · DOI
  49. Dall’ Acqua, 2017, Use of neuromuscular electrical stimulation to preserve the thickness of abdominal and chest muscles of critically ill patients: a randomized clinical trial, J Rehabil Med, 49, 40, 10.2340/16501977-2168 · DOI
  50. Machado, 2017, Effects that passive cycling exercise have on muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients: a randomized clinical trial, J Bras Pneumol, 43, 134, 10.1590/s1806-37562016000000170 · DOI
  51. Gruther, 2017, Can early rehabilitation on the general ward after an intensive care unit stay reduce hospital length of stay in survivors of critical illness?: a randomized controlled trial, Am J Phys Med Rehabil, 96, 607, 10.1097/PHM.0000000000000718 · DOI · Paper page
  52. Vitacca, 2016, Does 6-month home caregiver-supervised physiotherapy improve postcritical care outcomes?: a randomized controlled trial, Am J Phys Med Rehabil, 95, 571, 10.1097/PHM.0000000000000441 · DOI
  53. Fischer, 2016, Muscle mass, strength and functional outcomes in critically ill patients after cardiothoracic surgery: does neuromuscular electrical stimulation help? The Catastim 2 randomized controlled trial, Crit Care, 20, 30, 10.1186/s13054-016-1199-3 · DOI
  54. Patsaki, 2017, Effect of neuromuscular stimulation and individualized rehabilitation on muscle strength in intensive care unit survivors: a randomized trial, J Crit Care, 40, 76, 10.1016/j.jcrc.2017.03.014 · DOI

Cited by

Metadata

Authors
Morton, R. W., Traylor, D. A., Weijs, P. J. M., & Phillips, S. M.
Affiliations
  • Department of Kinesiology, McMaster University, Hamilton, Canada
  • Department of Nutrition and Dietetics, VU University
Venue
Current Opinion in Critical Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-04
Volume
24
Issue
2
Pages
124-130
ISSN
  • 1070-5295
  • 1531-7072
DOI
10.1097/mcc.0000000000000488
Cited by
106
References
15
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.