Effects of nutrition on neuro-endocrine stress responses

Rohleder, Nicolas; Kirschbaum, Clemens

doi:10.1097/mco.0b013e3281e38808

Cited by 40Regulation of Appetite and ObesityStress Responses and CortisolNeuropeptides and Animal Physiology

Effects of nutrition on neuro-endocrine stress responses

Rohleder, Nicolas, Kirschbaum, Clemens·2007·Current Opinion in Clinical Nutrition and Metabolic Care

DOI 10.1097/mco.0b013e3281e38808

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Abstract

PURPOSE OF REVIEW: Past studies in humans and animals have shown that low blood glucose concentrations due to fasting negatively interfere with the ability to mount a hypothalamus-pituitary-adrenal (HPA) axis response to psychological stress or to pharmacological activation, respectively. This contradicts the classical view of the proposed primary glucocorticoid function of providing the individual with energy in fight-or-flight situations. RECENT FINDINGS: Not many studies have followed up on this phenomenon in recent years, but our understanding of how appetite and satiety is regulated has significantly improved. Many of the neuropeptides involved in regulation of energy homeostasis interact with key areas of the HPA axis. The majority of orexigenic peptides have been shown to activate the HPA axis, while some anorexic peptides negatively modulate HPA axis activation and others also stimulate it. SUMMARY: The effects of orexigenic peptides on the HPA axis are incompatible with the phenomenon of blunted HPA axis activity in states of low energy available, while the fact that some anorexigenic peptides activate the HPA axis might point to a permissive role. In conclusion, current data insufficiently explain negative HPA axis modulation by low glucose levels.

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Stimulation of CRH release when wakefulness is extended could be mediated by upregulation of neuropeptides involved in the regulation of both energy homeostasis and HPA axis activity.
“This stimulation of CRH release when wakefulness is extended could be mediated by upregulation of neuropeptides involved in the regulation of both energy homeostasis and HPA axis activity (35).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [35]
In animals, intracerebroventricular injection of orexins activates the HPA axis by increasing CRH release in the paraventricular nucleus of the hypothalamus.
“In animals, intracerebroventricular injection of orexins activates the HPA axis by increasing CRH release in the paraventricular nucleus of the hypothalamus (35).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [35]

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Authors: Rohleder, N., & Kirschbaum, C.
Affiliations: University of British Columbia (CA)
Technische Universität Dresden (DE)
Corresponding author: Rohleder, Nicolas
ORCID: Rohleder, Nicolas
Kirschbaum, Clemens
Venue: Current Opinion in Clinical Nutrition and Metabolic Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-07
Volume: 10
Issue: 4
Pages: 504-510
ISSN: 1363-1950 (ISSN-L)
DOI: 10.1097/mco.0b013e3281e38808
OpenAlex: W2141142498
Cited by: 40
References: 96
Citations by year: 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 1
FWCI: 0.31
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: hypothalamic-pituitary-adrenal axis, neuroendocrine stress response, fasting, hypoglycemia, glucocorticoids, appetite regulation, satiety, neuropeptides, orexigenic peptides, anorexigenic peptides, energy homeostasis, psychological stress
MeSH terms: Appetite Regulation, Energy Metabolism, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Physiological

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Effects of nutrition on neuro-endocrine stress responses

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