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Cited by 309

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Vitamin D and its role in skeletal muscle

Open access
Ceglia, Lisa·2009·Current Opinion in Clinical Nutrition and Metabolic Care

Abstract

PURPOSE OF REVIEW: Vitamin D is best known for its role in regulating calcium homeostasis and in strengthening bone. However, it has become increasingly clear that it also has important beneficial effects beyond the skeleton, including muscle. This review summarizes current knowledge about the role of vitamin D in skeletal muscle tissue and physical performance. RECENT FINDINGS: Molecular mechanisms of vitamin D action in muscle tissue include genomic and nongenomic effects via a receptor present in muscle cells. Knockout mouse models of the vitamin D receptor provide insight into understanding the direct effects of vitamin D on muscle tissue. Vitamin D status is positively associated with physical performance and inversely associated with risk of falling. Vitamin D supplementation has been shown to improve tests of muscle performance, reduce falls, and possibly impact on muscle fiber composition and morphology in vitamin D deficient older adults. SUMMARY: Further studies are needed to fully characterize the underlying mechanisms of vitamin D action in human muscle tissue, to understand how these actions translate into changes in muscle cell morphology and improvements in physical performance, and to define the 25-hydroxyvitamin D level at which to achieve these beneficial effects in muscle.

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Metadata

Authors
Ceglia, L.
Venue
Current Opinion in Clinical Nutrition and Metabolic Care
Published
2009-11
Volume
12
Issue
6
Pages
628-633
ISSN
1363-1950 (ISSN-L)
OpenAlex
W2043365814
Cited by
309
References
5
FWCI
11.57
Type
journal article
Language
en
Open access
green

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