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Cited by 970Vitamin D Research StudiesBone health and osteoporosis researchHip and Femur Fractures

Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial

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A. Grant, FH Anderson, A Avenell, MK Campbell, C Cooper, C Donaldson, Roger Francis, WJ Gillespie +7 more·2005·The Lancet
DOI 10.1016/s0140-6736(05)63013-9
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Abstract

Background Elderly people who have a fracture are at high risk of another. Vitamin D and calcium supplements are often recommended for fracture prevention. We aimed to assess whether vitamin D3 and calcium, either alone or in combination, were effective in prevention of secondary fractures. Methods In a factorial-design trial, 5292 people aged 70 years or older (4481 [85%] of whom were women) who were mobile before developing a low-trauma fracture were randomly assigned 800 IU daily oral vitamin D3, 1000 mg calcium, oral vitamin D3 (800 IU per day) combined with calcium (1000 mg per day), or placebo. Participants who were recruited in 21 UK hospitals were followed up for between 24 months and 62 months. Analysis was by intention-to-treat and the primary outcome was new low-energy fractures. Findings 698 (13%) of 5292 participants had a new low-trauma fracture, 183 (26%) of which were of the hip. The incidence of new, low-trauma fractures did not differ significantly between participants allocated calcium and those who were not (331 [12.6%] of 2617 vs 367 [13.7%] of 2675; hazard ratio (HR) 0.94 [95% CI 0.81-1.09]); between participants allocated vitamin D3 and those who were not (353 [13.3%] of 2649 vs 345 [13.1%] of 2643; 1.02 [0.88-1.19]); or between those allocated combination treatment and those assigned placebo (165 [12.6%] of 1306 vs 179 [13.4%] of 1332; HR for interaction term 1.01 [0.75-1.36]). The groups did not differ in the incidence of all-new fractures, fractures…

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  • A large recent trial found calcium and vitamin D supplementation did not significantly lower fracture incidence.

    “in a large recent study, calcium and vitamin D supplementation did not reduce fracture incidence significantly”

    From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [35]

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Authors
Grant, A., Anderson, F., Avenell, A., Campbell, M., Cooper, C., Donaldson, C., Francis, R., Gillespie, W., Robinson, C., Torgerson, D., Wallace, W., McPherson, G., MacLennan, G., McDonald, A., & Francis, R. M.
Affiliations
  • University of Aberdeen (GB)
  • Newcastle University (GB)
ORCID
A. Grant
Venue
The Lancet
Publisher
Elsevier BV
Published
2005-05
Volume
365
Issue
9471
Pages
1621-1628
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(05)63013-9
OpenAlex
W1505358055
Cited by
970
References
2
Citations by year
2026: 5 · 2025: 13 · 2024: 18 · 2023: 36 · 2022: 13 · 2021: 20 · 2020: 20 · 2019: 26 · 2018: 34 · 2017: 32 · 2016: 29 · 2015: 29 · 2014: 52 · 2013: 63 · 2012: 48
FWCI
70.76
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Keywords
vitamin D3 supplementation, calcium supplementation, secondary fracture prevention, fragility fractures, hip fracture, older adults, osteoporosis, fracture risk, falls, quality of life, medication adherence, falls in older adults, RECORD trial, factorial design, bone mineral density, bone turnover markers
MeSH terms
Accidental Falls, Administration, Oral, Aged, Calcium, Cholecalciferol, Female, Humans, Male, Osteoporosis, Fractures, Bone

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