Receptor for advanced glycation endproducts and progressive kidney disease
Abstract
PURPOSE OF REVIEW: Receptor for advanced glycation endproducts (RAGE) is a multiligand receptor of the immunoglobulin superfamily, which binds not only to advanced glycation endproducts, but also to high-mobility group box-1, S100/calgranulins, amyloid fibrils, and lipopolysaccharide. We discuss the pathophysiological role of RAGE in both diabetic and nondiabetic progressive renal diseases, and its potential use for therapeutic interventions in these devastating disorders. RECENT FINDINGS: Although initial studies about RAGE focused on diabetic nephropathy, a number of recent findings have revealed that RAGE also actively participates in the pathogenesis of nondiabetic progressive renal diseases, including hypertensive nephropathy, obesity-related glomerulopathy, lupus nephritis, autosomal dominant polycystic kidney disease, renal amyloidosis, and septic acute kidney injury. Furthermore, blocking the RAGE by a neutralizing antibody or genetic deletion of RAGE was found to prevent the development and progression of various renal disorders. SUMMARY: The interaction of several RAGE ligands with RAGE plays a role in a broad range of progressive kidney diseases. The blockade of the various RAGE ligands-RAGE interactions might be a novel therapeutic strategy for preventing the development and progression of numerous progressive kidney diseases.
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Accumulation of AGEs in the kidney can elevate oxidative stress and inflammation, contributing to renal failure.
“The accumulation of AGEs in the kidney can elevate oxidative stress and inflammation, contributing to renal failure65.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [65]
Cites
Acute Renal Failure in Critically Ill Patients A Multinational, Multicenter Study
Uchino, S. (2005) · JAMA · doi:10.1001/jama.294.7.813 · Cited by 4,183 · see citing works
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
Rahman, A., & Isenberg, D. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmra071297 · Cited by 1,633 · see citing works
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works
Body Mass Index and Risk for End-Stage Renal Disease
Hsu, C.-Y., McCulloch, C. E., Iribarren, C., Darbinian, J., & Go, A. S. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-1-200601030-00006 · Cited by 1,390 · see citing works
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works
Obesity-related glomerulopathy: An emerging epidemic
Kambham, N., Markowitz, G. S., Valeri, A. M., Lin, J., & D’Agati, V. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041498.x · Cited by 1,279 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256 · see citing works
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434651100 · Cited by 1,126 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039 · see citing works
Review: history of the amyloid fibril.
Sipe, J., & Cohen, A. B. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4221 · Cited by 1,037 · see citing works
The Kidney, Hypertension, and Obesity
Hall, J. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000052314.95497.78 · Cited by 868 · see citing works
Schmidt, A. M., Vianna, M., Gerlach, M. L., Brett, J., Ryan, J., Kao, J. J., Esposito, C., Hegarty, H. M., Hurley, W. L., & Clauss, M. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42137-0 · Cited by 833 · see citing works
(2012) · Kidney International Supplements · doi:10.1038/kisup.2011.32 · Cited by 768 · see citing works
Wendt, T., Tanji, N., Guo, J., Kislinger, T., Qu, W., Lu, Y., Bucciarelli, L. G., Rong, L., Moser, B., Markowitz, G. S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63909-0 · Cited by 599 · see citing works
Liliensiek, B., Weigand, M. A., Bierhaus, A., Nicklas, W., Kasper, M. E., Hofer, S., Plachky, J., Gröne, H.-J., Kurschus, F. C., Schmidt, A. M., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18704 · Cited by 525 · see citing works
Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis
Takasu, O., Gaut, J. P., Watanabe, E., To, K. B., Fagley, R. E., Sato, B., Jarman, S., Efimov, I. R., Janks, D., Srivastava, A., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201211-1983oc · Cited by 515 · see citing works
Tanji, N., Markowitz, G. S., Fu, C., Kislinger, T., Taguchi, A., Pischetsrieder, M., Stern, D. M., Schmidt, A. M., & D’Agati, V. D. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1191656 · Cited by 485 · see citing works
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S.-I., Sakurai, S., Takasawa, S., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11771 · Cited by 475 · see citing works
Self-citationLiliensiek, B., Weigand, M. A., Bierhaus, A., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418704 · Cited by 468 · see citing works
Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy
Cooper, M. E. (2001) · Diabetologia · doi:10.1007/s001250100000 · Cited by 375 · see citing works
Hudson, B. I., Kalea, A. Z., Arriero, M. D. M., Harja, E., Boulanger, É., D’Agati, V. D., & Schmidt, A. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801465200 · Cited by 361 · see citing works
Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070810 · Cited by 352 · see citing works
Thallas‐Bonke, V., Thorpe, S. R., Coughlan, M. T., Fukami, K., Yap, F. Y. T., Sourris, K. C., Penfold, S. A., Bach, L. A., Cooper, M. E., & Forbes, J. M. (2007) · Diabetes · doi:10.2337/db07-1119 · Cited by 345 · see citing works
Self-citationYamagishi, S., Maeda, S., Matsui, T., Ueda, S., Fukami, K., & Okuda, S. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.014 · Cited by 296 · see citing works
Self-citationMiyata, T., Hori, O., Zhang, J., Yan, S. S., Ferran, L., Iida, Y., & Schmidt, A. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118889 · Cited by 278 · see citing works
Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes
Stern, D., Yan, S. D., Yan, S. D., & SCHMIDT, A. (2002) · Ageing Research Reviews · doi:10.1016/s0047-6374(01)00366-9 · Cited by 267 · see citing works
RAGE in tissue homeostasis, repair and regeneration
Sorci, G., Riuzzi, F., Giambanco, I., & Donato, R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.021 · Cited by 229 · see citing works
AGEs activate mesangial TGF-β–Smad signaling via an angiotensin II type I receptor interaction
Fukami, K., Ueda, S., Yamagishi, S., Kato, S., Inagaki, Y., Takeuchi, M., Motomiya, Y., Bucala, R., Iida, S., Tamaki, K., et al. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.66004.x · Cited by 218 · see citing works
Self-citationSeptic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS
Yamamoto, Y., Harashima, A., Saito, H., Tsuneyama, K., Munesue, S., Motoyoshi, S., Han, D., Watanabe, T., Asano, M., Takasawa, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002253 · Cited by 207 · see citing works
Podocyte Lesions in Patients With Obesity-Related Glomerulopathy
Chen, H., Liu, Z.-H., Zeng, C., Li, S., Wang, Q., & Leishi, L. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2006.07.025 · Cited by 193 · see citing works
Role of AGEs-RAGE System in Cardiovascular Disease
Fukami, K., Yamagishi, S., & Okuda, S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990475 · Cited by 193 · see citing works
Self-citationLong-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice
Flyvbjerg, A., Denner, L., Schrijvers, B. F., Tilton, R. G., Mogensen, T. H., Paludan, S. R., & Rasch, R. (2004) · Diabetes · doi:10.2337/diabetes.53.1.166 · Cited by 187 · see citing works
Insulin Resistance, Elevated Glomerular Filtration Fraction, and Renal Injury
Dengel, D. R., Goldberg, A. P., Mayuga, R. S., Kairis, G., & Weir, M. R. (1996) · Hypertension · doi:10.1161/01.hyp.28.1.127 · Cited by 159 · see citing works
Role of AGEs in Diabetic Nephropathy
Fukami, K., Yamagishi, S., Ueda, S., & Okuda, S. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784139710 · Cited by 150 · see citing works
Self-citationAngiogenesis in autosomal-dominant polycystic kidney disease
Bello-Reuss, E. N., Holubec, K., & Rajaraman, S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00768.x · Cited by 142 · see citing works
Yamagishi, S., Nakamura, K., Matsui, T., Ueda, S., Fukami, K., & Okuda, S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.7.983 · Cited by 138 · see citing works
Self-citationRAGE and the pathogenesis of chronic kidney disease
D’Agati, V. D., & Schmidt, A. M. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.54 · Cited by 135 · see citing works
Interactions between Renin Angiotensin System and Advanced Glycation in the Kidney
Thomas, M. C., Tikellis, C., Burns, W. M., Bialkowski, K., Cao, Z., Coughlan, M. T., Jandeleit-Dahm, K. A. M., Cooper, M. E., & Forbes, J. M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010013 · Cited by 135 · see citing works
Targeted reduction of advanced glycation improves renal function in obesity
Harcourt, B. E., Sourris, K. C., Coughlan, M. T., Walker, K. Z., Dougherty, S. L., Andrikopoulos, S., Morley, A. L., Thallas‐Bonke, V., Chand, V., Penfold, S. A., et al. (2011) · Kidney International · doi:10.1038/ki.2011.57 · Cited by 122 · see citing works
Ma, C., Jiao, Y., Zhang, J., Yang, Q., Zhang, Z., Shen, Y., Chen, Z., & Zhao, Y. (2010) · Rheumatology International · doi:10.1007/s00296-010-1636-6 · Cited by 115 · see citing works
Wen, Z., Xu, L., Chen, X., Xu, W., Yin, Z., Gao, X., & Xiong, S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203301 · Cited by 98 · see citing works
Dose-Dependent Effects of Sirolimus on mTOR Signaling and Polycystic Kidney Disease
Novalić, Z., van der Wal, A. M., Leonhard, W. N., Koehl, G. E., Breuning, M. H., Geissler, E. K., de Heer, E., & Peters, D. J. M. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011040340 · Cited by 93 · see citing works
Owen, W. F., Hou, F. F., Stuart, R. O., et al. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00882.x · Cited by 91 · see citing works
Expression of receptors for advanced glycosylated end-products in renal disease
Abel, M., Ritthaler, U., Zhang, Y., Deng, Y., Schmidt, A. M., Greten, H. J., Sernau, T., Wahl, P. R., Andrássy, K., Ritz, E., et al. (1995) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/10.9.1662 · Cited by 83 · see citing works
DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy
Kaida, Y., Fukami, K., Matsui, T., Higashimoto, Y., Nishino, Y., Obara, N., Nakayama, Y., Ando, R., Toyonaga, M., Ueda, S., et al. (2013) · Diabetes · doi:10.2337/db12-1608 · Cited by 78 · see citing works
Self-citationRenal effects of a neutralising RAGE-antibody in long-term streptozotocin-diabetic mice
Jensen, L. J. N., Denner, L. A., Schrijvers, B. F., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06524 · Cited by 76 · see citing works
Matsui, T., Yamagishi, S., Takeuchi, M., Ueda, S., Fukami, K., & Okuda, S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.004 · Cited by 64 · see citing works
Self-citationUrine levels of HMGB1 in Systemic Lupus Erythematosus patients with and without renal manifestations
Abdulahad, D. A., Westra, J., Bijzet, J., et al. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4015 · Cited by 62 · see citing works
Sun, W., Jiao, Y., Cui, B., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.61 · Cited by 61 · see citing works
The Axis AGE-RAGE-Soluble RAGE and Oxidative Stress in Chronic Kidney Disease
Gugliucci, A., & Menini, T. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_14 · Cited by 56 · see citing works
Martens, H., Nienhuis, H. L. A., Gross, S., van der Steege, G., Brouwer, E., Berden, J., de Sévaux, R. G. L., Derksen, R. H. W. M., Voskuyl, A. E., Berger, S., et al. (2012) · Lupus · doi:10.1177/0961203312444495 · Cited by 56 · see citing works
Sadik, N. A. H., Mohamed, W., & Ahmed, M. I. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1001-4 · Cited by 51 · see citing works
Autosomal dominant polycystic kidney disease.
Lieske, J. C., & Toback, F. G. (1993) · Journal of the American Society of Nephrology · doi:10.1681/asn.v381442 · Cited by 51 · see citing works
Suzuki, D., Toyoda, M., Yamamoto, N., Miyauchi, M., Katoh, M., Kimura, M., Maruyama, M., Honma, M., Umezono, T., & Yagame, M. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1557 · Cited by 50 · see citing works
Advanced Glycation End Products and Receptor for Advanced Glycation End Products in AA Amyloidosis
Röcken, C., Kientsch-Engel, R., Mansfeld, S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63917-x · Cited by 46 · see citing works
Effects of pyridoxamine (K-163) on glucose intolerance and obesity in high-fat diet C57BL/6J mice
Hagiwara, S., Gohda, T., Tanimoto, M., Ito, T., Murakoshi, M., Ohara, I., Yamazaki, T., Matsumoto, M., Horikoshi, S., Funabïki, K., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.033 · Cited by 41 · see citing works
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy
Wang, X.-C., Liu, C., CHEN, Y.-J., Wu, Y., YANG, L.-S., Liu, H., & LIAO, H.-L. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.1306 · Cited by 41 · see citing works
Effects of Specific Genes Activating RAGE on Polycystic Kidney Disease
Park, E. Y., Seo, M. J., & Park, J. H. (2010) · American Journal of Nephrology · doi:10.1159/000315859 · Cited by 39 · see citing works
Fukami, K., Yamagishi, S., Coughlan, M. T., Harcourt, B. E., Kantharidis, P., Thallas‐Bonke, V., Okuda, S., Cooper, M. E., & Forbes, J. M. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-86 · Cited by 39 · see citing works
Self-citationBrodska, H. L., Malíčková, K., Valenta, J., Fabio, A., & Drábek, T. (2013) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2013.849357 · Cited by 36 · see citing works
Lorenz, G., Desai, J., & Anders, H. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000444816.57378.21 · Cited by 35 · see citing works
Pattern of End Stage Renal Disease in a Tertiary Care Center
Khakurel, S., Agrawal, R. K., & Hada, R. (2009) · Journal of Nepal Medical Association · doi:10.31729/jnma.227 · Cited by 33 · see citing works
Tesch, G. H., Sourris, K. C., Summers, S. A., McCarthy, D. A., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A. R., Yap, F. Y. T., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3291-z · Cited by 31 · see citing works
Telmisartan inhibits AGE-induced podocyte damage and detachment
Fukami, K., Yamagishi, S., Kaifu, K., Matsui, T., Kaida, Y., Ueda, S., Takeuchi, M., Asanuma, K., & Okuda, S. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.04.006 · Cited by 29 · see citing works
Self-citationLiebisch, M., Bondeva, T., Franke, S., Daniel, C., Amann, K., & Wolf, G. (2014) · Kidney International · doi:10.1038/ki.2014.3 · Cited by 26 · see citing works
Clinical Study of Advanced Glycation End Products in Egyptian Diabetic Obese and Non-Obese Patients
Amin, M. N., Mosa, A. A., & El‐Shishtawy, M. M. (2011) · International Journal of Biomedical Science · doi:10.59566/ijbs.2011.7191 · Cited by 26 · see citing works
Hirasawa, Y., Matsui, Y., Yamane, K., et al. (2008) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.57.423 · Cited by 22 · see citing works
Agents in development for the treatment of diabetic nephropathy
Fukami, K., Cooper, M. E., & Forbes, J. M. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.3.279 · Cited by 18 · see citing works
Self-citationPark, E. Y., Kim, B. H., Lee, E. J., Chang, E., Kim, D. W., Choi, S. Y., & Park, J. H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.514166 · Cited by 18 · see citing works
Advanced glycation end product is implicated in amyloid‐related kidney complications
Matsunaga, N., Anan, I., Rosenberg, P. M., Nagai, R., Lundström, O., Horiuchi, S., Ando, Y., & Suhr, O. B. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510510013794 · Cited by 15 · see citing works
Anan, I., Kiuru‐Enari, S., Obayashi, K., et al. (2010) · PubMed · doi:10.14670/hh-25.691 · Cited by 10 · see citing works
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Bettiga, A., Fiorio, F., Di Marco, F., Trevisani, F., Romani, A., Porrini, E., Salonia, A., Montorsi, F., & Vago, R. (2019) · Nutrients · doi:10.3390/nu11081748 · Cited by 127 · see citing works
- Authors
- Fukami, K., Taguchi, K., Yamagishi, S.-I., & Okuda, S.
- Affiliations
- Kurume University (JP)
- Corresponding author
- Fukami, Kei
- Taguchi, Kensei
- Venue
- Current Opinion in Nephrology and Hypertension
- Published
- 2015-01
- Volume
- 24
- Issue
- 1
- Pages
- 54-60
- ISSN
- 1062-4821 (ISSN-L)
- OpenAlex
- W2063085024
- Cited by
- 46
- References
- 75
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 6
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Nephrology & Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- receptor for advanced glycation end products, RAGE, advanced glycation end products, high mobility group box 1, S100/calgranulins, amyloid fibrils, lipopolysaccharide, diabetic nephropathy, hypertensive nephropathy, obesity-related glomerulopathy, lupus nephritis, autosomal dominant polycystic kidney disease, renal amyloidosis, sepsis-associated acute kidney injury, therapeutic targeting
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Diabetic Nephropathies, Humans, Hypertension, Renal, Kidney Diseases, Ligands, Lupus Nephritis, Nephritis, Obesity, Receptors, Immunologic, Polycystic Kidney, Autosomal Dominant, Sepsis, Renal Insufficiency, Chronic, Acute Kidney Injury
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