Cited by 46Advanced Glycation End Products researchChronic Kidney Disease and DiabetesAcute Kidney Injury Research

Receptor for advanced glycation endproducts and progressive kidney disease

Fukami, Kei, Taguchi, Kensei, Yamagishi, Sho-ichi, Okuda, Seiya·2015·Current Opinion in Nephrology and Hypertension

Abstract

PURPOSE OF REVIEW: Receptor for advanced glycation endproducts (RAGE) is a multiligand receptor of the immunoglobulin superfamily, which binds not only to advanced glycation endproducts, but also to high-mobility group box-1, S100/calgranulins, amyloid fibrils, and lipopolysaccharide. We discuss the pathophysiological role of RAGE in both diabetic and nondiabetic progressive renal diseases, and its potential use for therapeutic interventions in these devastating disorders. RECENT FINDINGS: Although initial studies about RAGE focused on diabetic nephropathy, a number of recent findings have revealed that RAGE also actively participates in the pathogenesis of nondiabetic progressive renal diseases, including hypertensive nephropathy, obesity-related glomerulopathy, lupus nephritis, autosomal dominant polycystic kidney disease, renal amyloidosis, and septic acute kidney injury. Furthermore, blocking the RAGE by a neutralizing antibody or genetic deletion of RAGE was found to prevent the development and progression of various renal disorders. SUMMARY: The interaction of several RAGE ligands with RAGE plays a role in a broad range of progressive kidney diseases. The blockade of the various RAGE ligands-RAGE interactions might be a novel therapeutic strategy for preventing the development and progression of numerous progressive kidney diseases.

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Crossref · 10.1097/mnh.0000000000000091

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Authors
Fukami, K., Taguchi, K., Yamagishi, S.-I., & Okuda, S.
Affiliations
Kurume University (JP)
Corresponding author
  • Fukami, Kei
  • Taguchi, Kensei
Venue
Current Opinion in Nephrology and Hypertension
Published
2015-01
Volume
24
Issue
1
Pages
54-60
ISSN
1062-4821 (ISSN-L)
OpenAlex
W2063085024
Cited by
46
References
75
Citations by year
2026: 3 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 6
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Nephrology & Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Keywords
receptor for advanced glycation end products, RAGE, advanced glycation end products, high mobility group box 1, S100/calgranulins, amyloid fibrils, lipopolysaccharide, diabetic nephropathy, hypertensive nephropathy, obesity-related glomerulopathy, lupus nephritis, autosomal dominant polycystic kidney disease, renal amyloidosis, sepsis-associated acute kidney injury, therapeutic targeting
MeSH terms
Receptor for Advanced Glycation End Products, Animals, Diabetic Nephropathies, Humans, Hypertension, Renal, Kidney Diseases, Ligands, Lupus Nephritis, Nephritis, Obesity, Receptors, Immunologic, Polycystic Kidney, Autosomal Dominant, Sepsis, Renal Insufficiency, Chronic, Acute Kidney Injury

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