CoChat
Sign Up
Cited by 55

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

The life cycle of the low-density lipoprotein receptor: insights from cellular and in-vivo studies

Wijers, Melinde, Kuivenhoven, Jan A., van de Sluis, Bart·2015·Current Opinion in Lipidology
DOI 10.1097/mol.0000000000000157
Open this paper in CoChat — free account

Abstract

Purpose of review Long-term exposure to elevated concentrations of LDL cholesterol increases the risk of cardiovascular events. The main player in clearing LDL cholesterol is the LDL receptor (LDLR) trafficking pathway; however, our fundamental knowledge about the mechanisms regulating this pathway is still incomplete. Recent findings The LDLR pathway is very complex and involves multiple proteins. Endocytosis is regulated by two different adaptor proteins, that is, autosomal recessive hypercholesterolemia and Disabled-2. The proteolysis of the LDLR is regulated by inducible degrader of the LDLR and proprotein convertase subtilisin/kexin type 9. However, only a few proteins have been identified that provide insights into the endosomal sorting and recycling of the LDLR. Summary Since the discovery of LDLR, knowledge about its function has greatly expanded. As a result of its importance in maintaining homeostatic LDL levels, the LDLR pathway has emerged as a key therapeutic target to reduce circulating cholesterol. In order to be able to treat and diagnose individuals with hypercholesterolemia in the future, it is important to learn more about the LDLR trafficking pathway, as we still lack a full mechanistic understanding of how LDLR trafficking is controlled.

Overview

Integrity signals

Registry

Crossref · 10.1097/mol.0000000000000157

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 13 references

Research works printed but not linked: 49

  1. Brown, 1976, Science, 191, 150, 10.1126/science.174194 · DOI · Paper page
  2. Dieckmann, 2010, Biol Chem, 391, 1341, 10.1515/bc.2010.129 · DOI
  3. Gent, 2004, Cell Mol Life Sci, 61, 2461, 10.1007/s00018-004-4090-3 · DOI
  4. Usifo, 2012, Ann Hum Genet, 76, 387, 10.1111/j.1469-1809.2012.00724.x · DOI
  5. Chen, 1990, J Biol Chem, 265, 3116, 10.1016/S0021-9258(19)39742-X · DOI · Paper page
  6. Rudenko, 2002, Science, 298, 2353, 10.1126/science.1078124 · DOI · Paper page
  7. Brown, 1997, Nature, 388, 629, 10.1038/41672 · DOI · Paper page
  8. Grimm, 2014, Nat Commun, 5, 4699, 10.1038/ncomms5699 · DOI
  9. Bi, 2010, Subcell Biochem, 51, 319, 10.1007/978-90-481-8622-8_11 · DOI
  10. Stolt, 2006, Cell Signal, 18, 1560, 10.1016/j.cellsig.2006.03.008 · DOI
  11. Wu, 2003, J Biol Chem, 278, 44238, 10.1074/jbc.M309450200 · DOI
  12. Davis, 1986, Cell, 45, 15, 10.1016/0092-8674(86)90533-7 · DOI · Paper page
  13. Dvir, 2012, Proc Natl Acad Sci USA, 109, 6916, 10.1073/pnas.1114128109 · DOI
  14. Garcia, 2001, Science, 292, 1394, 10.1126/science.1060458 · DOI · Paper page
  15. Jones, 2003, J Biol Chem, 278, 29024, 10.1074/jbc.M304855200 · DOI · Paper page
  16. Jones, 2007, J Clin Invest, 117, 165, 10.1172/JCI29415 · DOI · Paper page
  17. Morris, 2001, Traffic, 2, 111, 10.1034/j.1600-0854.2001.020206.x · DOI · Paper page
  18. Mulkearns, 2012, Mol Biol Cell, 23, 1330, 10.1091/mbc.E11-09-0812 · DOI · Paper page
  19. Zhao, 2013, J Lipid Res, 54, 1550, 10.1194/jlr.M033167 · DOI
  20. Moore, 2013, BMC Dev Biol, 13, 39, 10.1186/1471-213X-13-39 · DOI · Paper page
  21. Yang, 2002, Dev Biol, 251, 27, 10.1006/dbio.2002.0810 · DOI · Paper page
  22. Yamamoto, 2003, Biochem Biophys Res Commun, 308, 270, 10.1016/S0006-291X(03)01358-5 · DOI
  23. Nokes, 2008, J Cell Biol, 182, 845, 10.1083/jcb.200802176 · DOI
  24. Shah, 2013, J Cell Biol, 202, 113, 10.1083/jcb.201211110 · DOI
  25. Maxwell, 2005, Proc Natl Acad Sci USA, 102, 2069, 10.1073/pnas.0409736102 · DOI · Paper page
  26. Zelcer, 2009, Science, 325, 100, 10.1126/science.1168974 · DOI · Paper page
  27. Abifadel, 2003, Nat Genet, 34, 154, 10.1038/ng1161 · DOI · Paper page
  28. Lagace, 2006, J Clin Invest, 116, 2995, 10.1172/JCI29383 · DOI · Paper page
  29. Poirier, 2009, J Biol Chem, 284, 28856, 10.1074/jbc.M109.037085 · DOI · Paper page
  30. Zhang, 2008, Proc Natl Acad Sci USA, 105, 13045, 10.1073/pnas.0806312105 · DOI · Paper page
  31. Tavori, 2013, Circulation, 127, 2403, 10.1161/CIRCULATIONAHA.113.001592 · DOI · Paper page
  32. Zhang, 2007, J Biol Chem, 282, 18602, 10.1074/jbc.M702027200 · DOI · Paper page
  33. Maxwell, 2003, J Lipid Res, 44, 2109, 10.1194/jlr.M300203-JLR200 · DOI · Paper page
  34. Wooten, 2014, Arch Biochem Biophys, 545, 124, 10.1016/j.abb.2014.01.018 · DOI
  35. My-Anh Nguyen, Kosenko, 2014, J Lipid Res, 55, 266, 10.1194/jlr.M044156 · DOI
  36. Calkin, 2014, Circ Res, 115, 442, 10.1161/CIRCRESAHA.115.304440 · DOI · Paper page
  37. Waterworth, 2010, Arterioscler Thromb Vasc Biol, 30, 2264, 10.1161/ATVBAHA.109.201020 · DOI · Paper page
  38. Sorrentino, 2013, Eur Heart J, 34, 1292, 10.1093/eurheartj/ehs472 · DOI
  39. Tessneer, 2013, J Can Res Updates, 2, 144
  40. Sen, 2012, Biomol Concepts, 3, 117, 10.1515/bmc-2011-0060 · DOI
  41. Kang, 2013, Mol Biol Cell, 24, 308, 10.1091/mbc.E12-02-0163 · DOI
  42. Du, 2012, Cell Rep, 1, 29, 10.1016/j.celrep.2011.10.004 · DOI
  43. Seidah, 2003, Proc Natl Acad Sci USA, 100, 928, 10.1073/pnas.0335507100 · DOI · Paper page
  44. Schneider, 1982, J Biol Chem, 257, 2664, 10.1016/S0021-9258(18)34975-5 · DOI · Paper page
  45. Yamamoto, 1984, Cell, 39, 27, 10.1016/0092-8674(84)90188-0 · DOI · Paper page
  46. Sudhof, 1985, Science, 228, 815, 10.1126/science.2988123 · DOI · Paper page
  47. Hudson, 2014, Nat Rev Drug Discov, 13, 807, 10.1038/nrd4475 · DOI
  48. Dadu, 2014, Nat Rev Cardiol, 11, 563, 10.1038/nrcardio.2014.84 · DOI
  49. Santos, 2014, ipidol, 25, 183

Cited by

Sorted by citations

See all 55

Metadata

Authors
Wijers, M., Kuivenhoven, J. A., & van de Sluis, B.
Venue
Current Opinion in Lipidology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-04
Volume
26
Issue
2
Pages
82-87
ISSN
0957-9672
DOI
10.1097/mol.0000000000000157
Cited by
55
References
13
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review