Update in facial nerve paralysis: tissue engineering and new technologies
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PURPOSE OF REVIEW: To present the recent advances in the treatment of facial paralysis, emphasizing the emerging technologies. This review will summarize the current state of the art in the management of facial paralysis and discuss the advances in nerve regeneration, facial reanimation, and use of novel biomaterials. This review includes surgical innovations in reinnervation and reanimation as well as progress with bioelectrical interfaces. RECENT FINDINGS: The last decade has witnessed major advances in the understanding of nerve injury and approaches for management. Key innovations include strategies to accelerate nerve regeneration, provide tissue-engineered constructs that may replace nonfunctional nerves, approaches to influence axonal guidance, limiting of donor-site morbidity, and optimization of functional outcomes. Approaches to muscle transfer continue to evolve, and new technologies allow for electrical nerve stimulation and use of artificial tissues. SUMMARY: The fields of biomedical engineering and facial reanimation increasingly intersect, with innovative surgical approaches complementing a growing array of tissue engineering tools. The goal of treatment remains the predictable restoration of natural facial movement, with acceptable morbidity and long-term stability. Advances in bioelectrical interfaces and nanotechnology hold promise for widening the window for successful treatment intervention and for restoring both lost neural inputs and muscle function.
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Cited by
Sorted by citations
Regenerative Electrode Interfaces for Neural Prostheses.
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- Authors
- Langhals, N. B., Urbanchek, M. G., Ray, A., & Brenner, M. J.
- Affiliations
- University of Michigan (US)
- Plastic Surgery Hospital (CN)
- Corresponding author
- Langhals, Nicholas B.
- Urbanchek, Melanie G.
- Venue
- Current Opinion in Otolaryngology & Head and Neck Surgery
- Published
- 2014-08
- Volume
- 22
- Issue
- 4
- Pages
- 291-299
- ISSN
- 1068-9508 (ISSN-L)
- PMC
- PMC4171729
- OpenAlex
- W2073652127
- Cited by
- 41
- References
- 52
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Otolaryngology & Head & Neck Surgery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (T32DC005356, K08DC012535)
- Topics
- Health Sciences › Medicine › Neurology › Facial Nerve Paralysis Treatment and Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- facial paralysis, facial reanimation, facial reinnervation, nerve regeneration, nerve injury, axon guidance, muscle transfer, electrical nerve stimulation, artificial tissue, nanotechnology, donor site morbidity
- MeSH terms
- Electric Stimulation Therapy, Facial Expression, Facial Paralysis, Humans, Nerve Regeneration, Neuronal Plasticity, Nerve Transfer, Tissue Engineering, Tissue Scaffolds
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