The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Effect of Sperm Morphology in Intrauterine Insemination: Analysis of 115 Cycles and Literature Review
Abstract
Importance: The value of morphology as a sperm parameter remains uncertain. Many studies have addressed the importance of morphology to predict the success of intrauterine insemination (IUI), but with conflicting results. Objective: The aims of this study were to review the current literature, to query our own clinical experience via a retrospective, descriptive study, and to determine whether the diagnosis of isolated teratozoospermia influences pregnancy rate after IUI. Results: We identified a large number of studies addressing this question. All were retrospective and most used different criteria to assess sperm morphology. Further complicating matters, the cutoff for normal morphology decreased from 15% to 4%. In our patient population, we found 12 cases of isolated teratozoospermia (10.43%). Only one of these produced an ongoing pregnancy and live birth. In all other cases, alteration of other sperm parameters coexisted (89.57%). These cycles produced a pregnancy rate of 13%, a nonsignficant difference. Pregnancy rates also were analyzed according to the percentage of normal morphology: 35.71% for less than 4%, 50% for 5% to 9%, and 14.29% for 10% to 14%. These rates did not differ significantly. Conclusions and Relevance: No consistent effect of sperm morphology on pregnancy rate was found in either the published literature or our own clinical experience. Larger and prospective studies are needed to identify any subtle effects of morphology on IUI outcomes that might exist. Target Audience: Obstetricians and gynecologists, family physicians. Learning Objectives: After participating in this activity, physicians should be better able to define features of teratozoospermia; describe pregnancy rates according to sperm morphology; determine if there are significant differences in patients' pregnancy rates for isolated teratozoospermia; and clarify whether these patients could benefit from in vitro fertilization/intracytoplasmic sperm injection.
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“However, existing literature shows the inconsistent impact of teratozoospermia on pregnancy outcomes and ART success (7,18,19)”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [18]
Citations
Cites
Matorras, R., Corcóstegui, B., Perez, C., Mandiola, M., Mendoza, R., & Rodríguez-Escudero, F. J. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57434-2 · Cited by 70
Isolated teratozoospermia and intrauterine insemination
Spiessens, C., Vanderschueren, D., Meuleman, C., & D'Hooghe, T. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01172-5 · Cited by 43
Isolated abnormal strict morphology is not a contraindication for intrauterine insemination
Lockwood, G. M., Deveneau, N. E., Shridharani, A. N., Strawn, E. Y., & Sandlow, J. I. (2015) · Andrology · doi:10.1111/andr.12098 · Cited by 34
Impact of isolated teratozoospermia on the outcome of intrauterine insemination
Grigoriou, O., Pantos, K., Makrakis, E., Hassiakos, D., Konidaris, S., & Creatsas, G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.08.027 · Cited by 19
Research works printed but not linked: 12
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- 1998, Predictive value of normal sperm morphology: a structured literature review, Hum Reprod Update, 4, 73, 10.1093/humupd/4.1.73 · DOI
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- 2012, Does sperm morphology affect the outcome of intrauterine insemination in patients with normal sperm concentration and motility?, Andrologia, 44, 299, 10.1111/j.1439-0272.2012.01280.x · DOI · Paper page
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Cited by
Sorted by citations
Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review
Atmoko, W., Savira, M., Shah, R., Chung, E., & Agarwal, A. (2024) · Translational Andrology and Urology · doi:10.21037/tau-23-397 · Cited by 23
“However, existing literature shows the inconsistent impact of teratozoospermia on pregnancy outcomes and ART success (7,18,19), and one study found that isolated teratozoospermia was more common in fertile than infertile males (20).”
Metadata
- Authors
- Fuentes Ávila, A., Blasco Sanz, R., & Cortés Alaguero, C.
- Affiliations
- Assistant Professor, Unidad de Reproducción Asistida Hospital Universitario La Plana de Vila-real
- Assistant Professor, Servicio de Obstetricia y Ginecología del Hospital Universitario La Plana de Vila-real, Castellón, Spain
- Professor, Conselleria de Sanitat de la Comunitat Valenciana, Valenciana, Spain
- Venue
- Obstetrical & Gynecological Survey
- Published
- 2021-03
- Volume
- 76
- Issue
- 3
- Pages
- 170-174
- ISSN
- 0029-7828 (ISSN-L)
- 1533-9866
- OpenAlex
- W3138183210
- Cited by
- 7
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrical & Gynecological Survey (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- sperm morphology, intrauterine insemination, teratozoospermia, pregnancy rate, live birth rate, semen parameters, assisted reproduction outcomes, in vitro fertilization, intracytoplasmic sperm injection
- MeSH terms
- Teratozoospermia, Female, Humans, Infertility, Insemination, Artificial, Male, Pregnancy, Pregnancy Rate, Semen Analysis
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- Fuentes Ávila, A., Blasco Sanz, R., & Cortés Alaguero, C. (2021). Effect of Sperm Morphology in Intrauterine Insemination: Analysis of 115 Cycles and Literature Review. Obstetrical & Gynecological Survey. https://doi.org/10.1097/ogx.0000000000000871
