Effects of Chronic Stress and Interleukin-10 Gene Polymorphisms on Antibody Response to Tetanus Vaccine in Family Caregivers of Patients with Alzheimer’s Disease
Abstract
OBJECTIVE: To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD). METHODS: A family-based follow-up study was conducted in 119 spouses and offspring of community-dwelling patients with AD. Psychological stress was measured by the Perceived Stress Scale (PSS) and the Center for Epidemiologic Studies Depression (CES-D) scale at baseline and 1 month after the vaccination. Nutritional status, health behaviors, comorbidity, and stress-buffering factors were assessed by self-administered questionnaires, 10 single nucleotide polymorphisms (SNP) from six selected cytokines genotyped, and anti-tetanus toxoid immunoglobulin G (IgG) concentrations tested using enzyme-linked immunosorbent assays. The effects of stress and other potential confounders were assessed by mixed models that account for familial correlations. RESULTS: The baseline PSS score, the baseline CES-D score, the interleukin-10-1082 A>G SNP GG genotype, and the baseline anti-tetanus IgG were inversely associated with antibody fold increase. CONCLUSION: Both psychological stress and cytokine gene polymorphisms affected antibody fold increase. The study provided additional support for the detrimental effects of psychological stress on the antibody response to tetanus vaccine.
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Caregivers of patients with Alzheimer's disease experience significant psychological stress, which negatively affects their immune response.
“For instance, caregivers of patients with Alzheimer’s disease experience significant psychological stress, which negatively affects their immune response.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [125]
A study on the antibody response to the tetanus vaccine in Alzheimer's caregivers found that higher baseline stress and depression scores were inversely associated with the antibody fold increase post-vaccination.
“A study on the antibody response to the tetanus vaccine in these caregivers found that higher baseline stress and depression scores were inversely associated with the antibody fold increase post-vaccination, underscoring the broader health implications of caregiving stress [125].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [125]
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- Authors
- Li, J., Cowden, L. G., King, J. D., Briles, D. A., Schroeder, H. W., Stevens, A. B., Perry, R. T., Chen, Z., Simmons, M. S., Wiener, H. W., Tiwari, H. K., Harrell, L. E., & Go, R. C. P.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Li, Jian
- Venue
- Psychosomatic Medicine
- Published
- 2007-07
- Volume
- 69
- Issue
- 6
- Pages
- 551-559
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2035622696
- Cited by
- 40
- References
- 50
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2012: 6
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (2R01 AG09029-15, R01AG009029)
- National Institute of Neurological Disorders and Stroke (NS045934-06, R01NS045934)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- chronic stress, tetanus vaccine, antibody response, Alzheimer's disease caregivers, family caregivers, cytokine gene polymorphisms, single nucleotide polymorphisms, immunosenescence, depression, stress buffering
- MeSH terms
- Aged, Alabama, Alzheimer Disease, Antibody Formation, Chronic Disease, Female, Humans, Immunoglobulin G, Male, Middle Aged, Regression Analysis, Risk Factors, Stress, Psychological, Tetanus Toxoid, Multivariate Analysis, Interleukin-10, Caregivers, Polymorphism, Single Nucleotide, White People
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