The Effect of Social Environment on Markers of Vascular Oxidative Stress and Inflammation in the Watanabe Heritable Hyperlipidemic Rabbit
Abstract
OBJECTIVE: Previous research demonstrated that social environment can influence progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic (WHHL) rabbit. This study examined the effect of social environment on markers of oxidative stress and inflammation to clarify the physiological pathways potentially responsible for the influence of social environment on disease. METHODS AND RESULTS: WHHL rabbits were assigned to 1 of 3 social groups: an unstable group, in which unfamiliar rabbits were paired daily, with the pairing switched each week; a stable group, in which littermates were paired daily; and an individually-caged group. The stable group engaged in more affiliative social behavior than the unstable group. The unstable group showed more agonistic behavior compared with the stable group and higher C-reactive protein levels than the individually caged group. The individually caged group was behaviorally sedentary, had higher 24-hour urinary catecholamine levels than the other groups, and exhibited higher NAD(P)H-oxidase activity in the aortic arch relative to the stable group. CONCLUSIONS: The results suggest that social environment creates distinct behavioral contexts that can affect markers of inflammation and oxidative stress early in the development of atherosclerosis. Specifically, physical inactivity associated with individual caging affects indices of oxidative stress and inflammation. These pathophysiological markers may help to explain behaviorally related differences in the extent of atherosclerosis observed in prior studies.
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Social isolation increases 24-hour urinary catecholamines and evidence of oxidative stress in the aortic arch of Watanabe heritable hyperlipidemic rabbits.
“increases the 24 hour urinary catecholamines levels and evidence of oxidative stress in the aortic arch of the Watanabe heritable hyperlipidemic rabbit;19”
From Social isolation (2011) · cites this paper as [19]
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- Authors
- Nation, D. A., Gonzales, J. A., Mendez, A. J., Zaias, J., Szeto, A., Brooks, L. G., Paredes, J., D’Angola, A., Schneiderman, N., & McCabe, P. M.
- Affiliations
- University of Miami (US)
- Corresponding author
- McCabe, Philip M.
- Venue
- Psychosomatic Medicine
- Published
- 2008-04
- Volume
- 70
- Issue
- 3
- Pages
- 269-275
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W1994386221
- Cited by
- 39
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL036588, HL36588, HL-04726)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- social environment, atherosclerosis, oxidative stress, inflammation, Watanabe heritable hyperlipidemic rabbits, social isolation, physical inactivity, affiliative behavior, agonistic behavior, C-reactive protein, urinary catecholamines, NADPH oxidase, aortic arch, social stress
- MeSH terms
- Agonistic Behavior, Angiotensin II, Animals, Aorta, Thoracic, Arousal, C-Reactive Protein, Cholesterol, Epinephrine, Hyperlipidemias, Peptidyl-Dipeptidase A, Lipoproteins, HDL, Lipoproteins, LDL, Male, Norepinephrine, Rabbits, Social Environment, Social Isolation, Stress, Psychological, Reactive Oxygen Species, Oxidative Stress, Inflammation Mediators, NADPH Oxidases, Receptor, Angiotensin, Type 1, Atherosclerosis
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