Modeling Social Influences on Human Health
Open accessAbstract
Social interactions have long-term physiological, psychological, and behavioral consequences. Social isolation is a well-recognized but little understood risk factor and prognostic marker of disease; it can have profoundly detrimental effects on both mental and physical well-being, particularly during states of compromised health. In contrast, the health benefits associated with social support (both reduced risk and improved recovery) are evident in a variety of illnesses and injury states; however, the mechanisms by which social interactions influence disease pathogenesis remain largely unidentified. The substantial health impact of the psychosocial environment can occur independently of traditional disease risk factors and is not accounted for solely by peer-encouraged development of health behaviors. Instead, social interactions are capable of altering shared pathophysiological mechanisms of multiple disease states in distinct measurable ways. Converging evidence from animal models of injury and disease recapitulates the physiological benefits of affiliative social interactions and establishes several endogenous mechanisms (inflammatory signals, glucocorticoids, and oxytocin) by which social interactions influence health outcomes. Taken together, both clinical and animal research are undoubtedly necessary to develop a complete mechanistic understanding of social influences on health.
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Social support has been linked with improved health outcomes, including better adherence and increased exercise tolerance among the elderly and cardiac rehabilitation populations.
“Additionally, social support has been linked with improved health outcomes, including better adherence and increased exercise tolerance among the elderly and cardiac rehabilitation populations.36,37”
From Cognitive behavioral therapy for management of dyspnea: A pilot study (2015) · cites this paper as [37]
In “Social influences on health” (page unavailable), the paper links social support with better medical compliance, increased physical exercise, and improved recovery from cardiovascular disease. It does not report increased exercise tolerance or establish those specific outcomes in elderly and cardiac rehabilitation populations; physical exercise is not the same as exercise tolerance. (LLM, conf=0.87)
Experimental — accuracy not yet measuredLow social support is associated with poor physical and mental health.
“Low social support is a key factor related to serious negative health outcomes, including poor physical and mental health, increased mortality risk, and suicidal ideation and behavior [1,2,3,4].”
From A Randomized Pilot Study of Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD (2022) · cites this paper as [2]
Low social support is associated with increased mortality risk.
“Low social support is a key factor related to serious negative health outcomes, including poor physical and mental health, increased mortality risk, and suicidal ideation and behavior [1,2,3,4].”
From A Randomized Pilot Study of Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD (2022) · cites this paper as [2]
Low social support is associated with suicidal ideation and behavior.
“Low social support is a key factor related to serious negative health outcomes, including poor physical and mental health, increased mortality risk, and suicidal ideation and behavior [1,2,3,4].”
From A Randomized Pilot Study of Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD (2022) · cites this paper as [2]
The Social influences on health section links social support to health behaviors and disease-related measures, but does not address suicidal ideation or behavior. Searches for “suicidal ideation and behavior” and “suicide social isolation suicidal behavior” found no passage in our copy supporting that specific association. (LLM, conf=0.73)
Experimental — accuracy not yet measuredVeterans with PTSD are a population at high risk of mortality and other negative outcomes.
“a population at high risk of mortality and other negative outcomes [1,2,3,4].”
From A Randomized Pilot Study of Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD (2022) · cites this paper as [2]
The “Social influences on health” section discusses psychological stress, social isolation, and adverse disease outcomes generally, but does not address mortality risk among veterans with PTSD. Searches for veterans, PTSD, and mortality found no passage in our copy that establishes the attributed claim. (LLM, conf=0.75)
Experimental — accuracy not yet measured
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Oxytocin pathways and the evolution of human behavior
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“Consequently, research interest has turned to the neurobiological mechanisms underlying the effects of couple interaction on stress and individual health-relevant outcomes (Uchino et al., 1996; Robles and Kiecolt-Glaser, 2003; Karelina and DeVries, 2011).”
BackgroundOnline intimacy and well-being in the digital age
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The effect of raising and lowering tryptophan levels on human mood and social behaviour
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Long-term familiarity creates preferred social partners in dairy cows
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NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology
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Stress and social isolation increase vulnerability to stroke
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The joint impact of parental psychological neglect and peer isolation on adolescents' depression
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Lifelong consequences of brain injuries during development: From risk to resilience
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Self-citationFacilitation of Serotonin Signaling by SSRIs is Attenuated by Social Isolation
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Impact of a Senior Fitness Program on Measures of Physical and Emotional Health and Functioning
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Leisure Substitution and Problem Gambling: Report of a Proof of Concept Group Intervention
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Self-citationThe Intersection of Culture and Solitude
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Self-citationSocial environment as a modulator of immunosenescence
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- Authors
- Karelina, K., & DeVries, A. C.
- Affiliations
- National Institute of Neurological Disorders and Stroke (US)
- Corresponding author
- Karelina, Kate
- Venue
- Psychosomatic Medicine
- Published
- 2011-01
- Volume
- 73
- Issue
- 1
- Pages
- 67-74
- ISSN
- 0033-3174 (ISSN-L)
- PMC
- PMC3076601
- OpenAlex
- W2102004733
- Cited by
- 115
- References
- 103
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 4 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 10
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL080249)
- National Institute of Nursing Research (R01NR010806)
- National Institute of Neurological Disorders and Stroke (P30NS045758, R01NS40267-05, R01NS040267)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- social isolation, social support, social interaction, psychosocial environment, disease risk factors, recovery from illness, inflammation, glucocorticoids, oxytocin, affiliative behavior, pathogenesis, psychophysical well-being
- MeSH terms
- Adaptation, Psychological, Adult, Animals, Cause of Death, Child, Chronic Disease, Disease Models, Animal, Female, Cricetinae, Health Status, Humans, Interpersonal Relations, Male, Risk Factors, Social Environment, Social Support, United States, Health Behavior, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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