Cited by 106Telomeres, Telomerase, and SenescenceCardiac Health and Mental HealthHealth disparities and outcomes

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Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease: Data From The Heart and Soul Study

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Hoen, Petra W., de Jonge, Peter, Na, Bee Ya, Farzaneh-Far, Ramin, Epel, Elissa, Lin, Jue, Blackburn, Elizabeth, Whooley, Mary A.·2011·Psychosomatic Medicine

DOI 10.1097/psy.0b013e31821b1f6ePMC PMC3161173

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Abstract

OBJECTIVE: Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered as an emerging marker of biologic age. Whether depression is associated with telomere length or trajectory has not been evaluated in patients with CHD. METHODS: In a prospective cohort study, we measured leukocyte telomere length in 952 participants with stable CHD at baseline and in 608 of these participants after 5 years of follow-up. The presence of major depressive disorder in the past month was assessed using the computerized diagnostic interview schedule at baseline. We used linear and logistic regression models to evaluate the association of depression with baseline and 5-year change in leukocyte telomere length. RESULTS: Of the 952 participants, 206 (22%) had major depression at baseline. After the adjustment for age and sex, the patients with current major depressive disorder had shorter baseline telomere length than those without depression (mean [standard error] = 0.86 [0.02] versus 0.90 [0.01]; p = .02). This association was similar (but no longer statistically significant) after adjustment for body mass index, smoking, diabetes, left ventricular ejection fraction, statin use, antidepressant use, physical inactivity, and anxiety (0.85 [0.02] versus 0.89 [0.01], p = .06). Depression was not predictive of 5-year change in telomere length after adjustment for the mentioned covariates and baseline telomere length. CONCLUSIONS: Depression is associated with reduced leukocyte telomere length in patients with CHD but does not predict 5-year change in telomere length. Future research is necessary to elucidate the potential mechanisms underlying the association between depression and telomere length.

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Authors: Hoen, P. W., de Jonge, P., Na, B. Y., Farzaneh-Far, R., Epel, E., Lin, J., Blackburn, E., & Whooley, M. A.
Affiliations: University Medical Center Groningen (NL)
San Francisco VA Medical Center (US)
University of California, San Francisco (US)
University of San Francisco (US)
Corresponding author: Hoen, Petra W.
ORCID: Epel, Elissa
Lin, Jue
Blackburn, Elizabeth
Whooley, Mary A.
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-09
Volume: 73
Issue: 7
Pages: 541-547
ISSN: 0033-3174 (ISSN-L)
DOI: 10.1097/psy.0b013e31821b1f6e
PMC: PMC3161173
OpenAlex: W2048279184
Cited by: 106
References: 38
Citations by year: 2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 10 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 14 · 2014: 12 · 2013: 13 · 2012: 10
FWCI: 8.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: U.S. Department of Veterans Affairs (R01 HL079235)
American Heart Association
Ischemia Research and Education Foundation (R01 HL079235)
Health Services Research and Development
Medical Research Council
National Heart, Lung, and Blood Institute (R01HL079235)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Social Sciences › Health › Health disparities and outcomes
Keywords: depression, leukocyte telomere length, coronary artery disease, telomere shortening, major depressive disorder, biological age, stable coronary artery disease
MeSH terms: Aged, Coronary Artery Disease, Major Depressive Disorder, Female, Humans, Leukocytes, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Biomarkers, Chi-Square Distribution, Linear Models, Logistic Models, Telomere

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Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease: Data From The Heart and Soul Study

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