Leukocyte telomere length and late-life depression
Abstract
Objective Depressive disorders have been associated with increased risk for aging-related diseases, possibly as a consequence of accelerated cellular aging. Cellular aging, indexed by telomere length (TL) shortening, has been linked to depression in adults younger than 60 years; however, it remains unclear whether this is the case in late-life depression (age >60 years). The objective of this study was to assess differences in TL between persons with current late-life depression and never-depressed comparisons and to examine the association between characteristics of late-life depression and TL.Methods In this cross-sectional study using the Netherlands Study of Depression in Older Persons, 355 persons with current late-life depression and 128 never-depressed comparisons, aged 60-93 years (mean age [SD]: 70.5 [7.4] years, 65% women), were recruited through primary care and mental healthcare. Late-life depression was established using a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-based structured psychiatric interview. Leukocyte TL, expressed in base pairs (bp), was determined in fasting blood samples by performing quantitative polymerase chain reaction.Results Mean TL did not differ between depressed persons (bp [SD]: 5,035 [431]) and never-depressed (bp [SD]: 5,057 [729]) comparisons. Further, TL was not associated with severity, duration, and age at onset of depression; comorbid anxiety disorders; anxiety symptoms; apathy severity; antidepressant use; benzodiazepine use; cognitive functioning; and childhood trauma.Conclusion Late-life depression was not associated with increased cellular aging. This absent association, which contradicts observations in younger adults, may be due to the potential larger heterogenic nature of late-life depression and lifetime cumulative exposure to other TL-damaging factors, possibly overruling effects of late-life depression.
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Of studies having greater than 40 depressed subjects, all except two found significantly shorter LTL in MDD.
“Of studies having greater than 40 depressed subjects, all except two (Needham et al., 2014; Schaakxs et al., 2015) found significantly shorter LTL in MDD (Hartmann et al., 2010; Hoen et al., 2011; Lung et al., 2007; Simon et al., 2006; Verhoeven et al., 2014a; Wikgren et al., 2012b).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Schaakxs et al., 2015
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- Authors
- Schaakxs, R., Verhoeven, J. E., Oude Voshaar, R. C., Comijs, H. C., & Penninx, B. W. J. H.
- Affiliations
- Amsterdam Public Health (NL)
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 23
- Issue
- 4
- Pages
- 423-432
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W1973683611
- Cited by
- 75
- References
- 46
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 11 · 2018: 5 · 2017: 6 · 2016: 10 · 2015: 14
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Fonds NutsOhra
- Stichting tot Steun VCVGZ
- NARSAD The Brain and Behaviour Research Fund
- NWO-VICI (91811602)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Health › Health disparities and outcomes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- geriatric depression, leukocyte telomere length, cellular aging, accelerated aging, telomere shortening, older adults, depression severity, anxiety comorbidity, childhood trauma, antidepressant use, benzodiazepine use, cognitive function
- MeSH terms
- Late Onset Disorders, Aged, Aged, 80 and over, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Leukocytes, Male, Middle Aged, Netherlands, Comorbidity, Case-Control Studies, Age of Onset, Telomere Shortening
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