Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB/c mouse
Open accessAbstract
Stress has profound influence on the gastro-intestinal tract, the immune system and the behavior of the animal. In this study, the correlation between gut microbiota composition determined by Denaturing Grade Gel Electrophoresis (DGGE) and tag-encoded 16S rRNA gene amplicon pyrosequencing (454/FLX) and behavior in the Tripletest (Elevated Plus Maze, Light/Dark Box, and Open Field combined), the Tail Suspension Test, and Burrowing in 28 female BALB/c mice exposed to two weeks of grid floor induced stress was investigated. Cytokine and glucose levels were measured at baseline, during and after exposure to grid floor. Stressing the mice clearly changed the cecal microbiota as determined by both DGGE and pyrosequencing. Odoribacter, Alistipes and an unclassified genus from the Coriobacteriaceae family increased significantly in the grid floor housed mice. Compared to baseline, the mice exposed to grid floor housing changed the amount of time spent in the Elevated Plus Maze, in the Light/Dark Box, and burrowing behavior. The grid floor housed mice had significantly longer immobility duration in the Tail Suspension Test and increased their number of immobility episodes from baseline. Significant correlations were found between GM composition and IL-1α, IFN-γ, closed arm entries of Elevated Plus Maze, total time in Elevated Plus Maze, time spent in Light/Dark Box, and time spent in the inner zone of the Open Field as well as total time in the Open Field. Significant correlations were found to the levels of Firmicutes, e.g. various species of Ruminococccaceae and Lachnospiraceae. No significant difference was found for the evaluated cytokines, except an overall decrease in levels from baseline to end. A significant lower level of blood glucose was found in the grid floor housed mice, whereas the HbA1c level was significantly higher. It is concluded that grid floor housing changes the GM composition, which seems to influence certain anxiety-related parameters.
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Psychological stress, physical activity, tobacco use, alcohol consumption, and antibiotic exposure are modifying factors for the gut microbiome.
“Other modifying factors (Figure 1) include psychological stress33,34, physical activity35, tobacco use36, alcohol consumption37, and antibiotic exposure38, 39,40.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [33]
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Muyzer, G., de Waal, E. C., & Uitterlinden, A. G. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.695-700.1993 · Cited by 11,379 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR ampliconsPreprint
Haas, B. J., Gevers, D., Earl, A. M., Feldgarden, M., Ward, D. V., Giannoukos, G., Ciulla, D., Tabbaa, D., Highlander, S. K., Sodergren, E. J., et al. (2011) · Genome Research · doi:10.1101/gr.112730.110 · Cited by 3,451 · see citing works
PyNAST: a flexible tool for aligning sequences to a template alignment
Caporaso, J. G., Bittinger, K. L., Bushman, F. D., DeSantis, T. Z., Andersen, G. L., & Knight, R. D. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp636 · Cited by 3,374 · see citing works
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · see citing works
An overview of the immune system
Parkin, J., & Cohen, B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04904-7 · Cited by 1,463 · see citing works
Bourin, M., & Hascoët, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01274-3 · Cited by 1,440 · see citing works
Twenty years of research on cytokine-induced sickness behavior
Dantzer, R., & Kelley, K. W. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.006 · Cited by 1,420 · see citing works
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235 · see citing works
A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety
Hogg, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02126-4 · Cited by 1,169 · see citing works
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123 · see citing works
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Anxiety, defence and the elevated plus-maze.
Rodgers, R., & Dalvi, A. (1997) · Neuroscience and Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00058-9 · Cited by 1,028 · see citing works
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952 · see citing works
Ubeda, C., Taur, Y., Jenq, R. R., Equinda, M. J., Son, T., Samstein, M., Viale, A., Socci, N. D., van den Brink, M. R. M., Kamboj, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43918 · Cited by 943 · see citing works
Zoetendal, E. G., von Wright, A., Vilpponen-Salmela, T., Ben-Amor, K., Akkermans, A. D. L., & de Vos, W. M. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.7.3401-3407.2002 · Cited by 868 · see citing works
Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to Disease
Elenkov, I. J., & Chrousos, G. P. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00188-5 · Cited by 804 · see citing works
Cytokine, Sickness Behavior, and Depression
Dantzer, R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.002 · Cited by 789 · see citing works
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
Saulnier, D. M., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E. M., Qin, X., Coarfa, C., Milosavljevic, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.072 · Cited by 672 · see citing works
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
Linkage of gut microbiome with cognition in hepatic encephalopathy
Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2011 · Cited by 547 · see citing works
Animal models of anxiety and depression: how are females different?
Palanza, P. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00010-0 · Cited by 545 · see citing works
Hansen, C. H. F., Krych, Ł., Nielsen, D. S., Vogensen, F. K., Hansen, L. H., Sørensen, S. J., Buschard, K., & Hansen, A. K. (2012) · Diabetologia · doi:10.1007/s00125-012-2564-7 · Cited by 496 · see citing works
Self-citationRole of the gut microbiota in defining human health
Fujimura, K. E., Slusher, N. A., Cabana, M. D., & Lynch, S. V. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.14 · Cited by 408 · see citing works
Martínez, I., Wallace, G., Zhang, C., Legge, R. M., Benson, A. K., Carr, T. P., Moriyama, E. N., & Walter, J. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-09 · Cited by 355 · see citing works
Beneficial Effects of Soy Phytoestrogen Intake in Postmenopausal Women With Type 2 Diabetes
Jayagopal, V., Albertazzi, P., Kilpatrick, E. S., Howarth, E., Jennings, P. E., Hepburn, D. A., & Atkin, S. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1709 · Cited by 345 · see citing works
Burrowing in rodents: a sensitive method for detecting behavioral dysfunction
Deacon, R. M. J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.19 · Cited by 314 · see citing works
Walk, S. T., Blum, A. M., Ewing, S., Weinstock, J. V., & Young, V. B. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21299 · Cited by 313 · see citing works
Effects of intestinal microbiota on anxiety-like behavior
Neufeld, K.-A. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.15702 · Cited by 311 · see citing works
Martı́, O., Martı́, J., & Armario, A. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90055-8 · Cited by 305 · see citing works
The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome
Chang, L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.032 · Cited by 268 · see citing works
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Salonen, A., de Vos, W. M., & Palva, A. (2010) · Microbiology · doi:10.1099/mic.0.043257-0 · Cited by 264 · see citing works
Hedrich, H. J. (2012) · doi:10.1016/c2009-0-60982-x · Cited by 259 · see citing works
Hufeldt, M. R., Nielsen, D. S., Vogensen, F. K., Midtvedt, T., & Hansen, A. K. (2010) · PubMed Central · Cited by 202 · see citing works
Self-citationAntidepressant-like effects in various mice strains in the tail suspension test
Ripoll, N., David, D. J. P., Dailly, É., Hascoët, M., & Bourin, M. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00034-2 · Cited by 182 · see citing works
Ramos, A., Pereira, E. C., Martins, G. C. A., Wehrmeister, T. D., & Izídio, G. S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.007 · Cited by 172 · see citing works
The importance of the development of the intestinal microbiota in infancy
Vael, C., & Desager, K. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328332351b · Cited by 158 · see citing works
Matthies, A., Clavel, T., Gütschow, M., Engst, W., Haller, D., Blaut, M., & Braune, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00555-08 · Cited by 141 · see citing works
Erratum: Enterotypes of the human gut microbiome
Arumugam, M., Raes, J., Pelletier, É., Paslier, D. L., Yamada, T., Mende, D. R., Fernandes, G. D. R., Tap, J., Brüls, T., Batto, J.-M., et al. (2011) · Nature · doi:10.1038/nature10187 · Cited by 138 · see citing works
Burrowing: A sensitive behavioural assay, tested in five species of laboratory rodents
Deacon, R. M. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.007 · Cited by 129 · see citing works
Caso, J. R., Leza, J. C., & Menchen, L. A. (2008) · Current Molecular Medicine · doi:10.2174/156652408784533751 · Cited by 127 · see citing works
Nagai, F., Morotomi, M., Watanabe, Y., Sakon, H., & Tanaka, R. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.014571-0 · Cited by 116 · see citing works
A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice
Solberg, L. C., Valdar, W. S. J., Gauguier, D., Nunez, G., Taylor, A. M., Heyes, S. B., Arboledas-Hita, C., Hernandez-Pliego, P., Davidson, S. I., Burns, P., et al. (2006) · Mammalian Genome · doi:10.1007/s00335-005-0112-1 · Cited by 112 · see citing works
Husum, H., Termeer, E. H., Mathé, A. A., Bolwig, T. G., & Ellenbroek, B. A. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00038-2 · Cited by 94 · see citing works
Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests
Fraser, L. M., Brown, R. E., Hussin, A. T., Fontana, M., Whittaker, A., O’Leary, T. P., Lederle, L. I., Holmes, A., & Ramos, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1873-0 · Cited by 85 · see citing works
Metabolites of Daidzein and Genistein and Their Biological Activities
Chang, Y., Nair, M. G., & Nitiss, J. L. (1995) · Journal of Natural Products · doi:10.1021/np50126a016 · Cited by 85 · see citing works
Time to include the gut microbiota in the hygienic standardisation of laboratory rodents
Bleich, A., & Hansen, A. K. (2012) · Comparative Immunology, Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2011.12.006 · Cited by 82 · see citing works
Self-citationInterleukin-23 and Th17 Cells in the Control of Gut Inflammation
Monteleone, I., Pallone, F., & Monteleone, G. (2009) · Mediators of Inflammation · doi:10.1155/2009/297645 · Cited by 81 · see citing works
Effects of gut microbiota on the brain: implications for psychiatry
Neufeld, K. M., & Foster, J. A. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0931 · Cited by 75 · see citing works
Quantitative aspects of stress-induced immunomodulation
Pruett, S. B. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(00)00030-8 · Cited by 74 · see citing works
Wolin, M. J., Miller, T. L., Collins, M. D., & Lawson, P. A. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.10.6321-6326.2003 · Cited by 70 · see citing works
Isolation rearing-induced disruption of prepulse inhibition
Weiss, I. C., Feldon, J., & Domeney, A. M. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199903000-00003 · Cited by 69 · see citing works
Telemetry as a Method for Measuring the Impact of Housing Conditions on Rats' Welfare
Krohn, T. C., Hansen, A. K., & Dragsted, N. (2003) · Animal Welfare · doi:10.1017/s0962728600025379 · Cited by 48 · see citing works
Self-citationFaecal and caecal microbiota profiles of mice do not cluster in the same way
Pang, W., Vogensen, F. K., Nielsen, D. S., & Hansen, A. K. (2012) · Laboratory Animals · doi:10.1258/la.2012.011128 · Cited by 43 · see citing works
Self-citationHufeldt, M. R., Nielsen, D. S., Vogensen, F. K., Midtvedt, T., & Hansen, A. K. (2010) · Laboratory Animals · doi:10.1258/la.2010.010058 · Cited by 42 · see citing works
Self-citationSim, Y., Park, S.-H., Kang, Y.-J., Kim, S., Lee, J.-K., Jung, J., & Suh, H. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1018-3 · Cited by 34 · see citing works
Cytokines, Sickness Behavior, and Depression
Dantzer, R., Bluthé, R.-M., Castanon, N., Kelley, K. W., Konsman, J. P., Layé, S., Lestage, J., & Parnet, P. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50019-8 · Cited by 32 · see citing works
Comparison of fecal biota from specific pathogen free and feral mice
Wilson, K. H., Brown, R. S., Andersen, G. L., Tsang, J., & Sartor, R. B. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.09.002 · Cited by 31 · see citing works
Mouse Models for Studying Depression-Like States and Antidepressant Drugs.
Bergner, C., Smolinsky, A., Hart, P., Dufour, B., Egan, R., Laporte, J., & Kalueff, A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3661-8_15 · Cited by 25 · see citing works
Mouse Models for Studying Depression-Like States and Antidepressant Drugs
Bergner, C., Smolinsky, A. N., Hart, P. C., Dufour, B. D., Egan, R. J., LaPorte, J. L., & Kalueff, A. V. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-058-8_16 · Cited by 22 · see citing works
Wolin, M. J., Miller, T. L., & Lawson, P. A. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65850-0 · Cited by 21 · see citing works
Ritskes‐Hoitinga, M. (2004) · Elsevier eBooks · doi:10.1016/b978-012336425-8/50081-9 · Cited by 17 · see citing works
Fluctuating Asymmetry in Relation to Stress and Social Status in Inbred Male Lewis Rats
̧rensen, D. B. S., Jegstrup, I. M., Ritskes-Hoitinga, M. J., & Hansen, A. K. (2005) · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [21]Stub C, Sorensen DB, Jegstrup IM, Ritskes-Hoitinga M, Hansen AK (2002) Fluctuating asymmetry of teeth is not a reliable indicator for assessing stress in rats. Scandinavian Journal of Laboratory Animal Science 29: 149– 153.
- [37]Hansen CHF, Nielsen DS, Kverka M, Zakostelka Z, Klimesova K, et al. (2012) Customizing laboratory mice by modifying gut microbiota and immune system development in the early postnatal period. PLoS One (In Press).
Cited by
Sorted by citations
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Parker, B. J., Wearsch, P. A., Veloo, A. C. M., & Rodriguez‐Palacios, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00906 · Cited by 1,732 · see citing works
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651 · see citing works
The microbiome and host behavior
Vuong, H. E., Yano, J. M., Fung, T. C., & Hsiao, E. Y. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031347 · Cited by 537 · see citing works
Circadian disorganization alters intestinal microbiota
Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097500 · Cited by 439 · see citing works
Altered gut microbiota and activity in a murine model of autism spectrum disorders
de Theije, C. G. M., Wopereis, H., Ramadan, M., van Eijndthoven, T., Lambert, J., Knol, J., Garssen, J., Kraneveld, A. D., & Oozeer, R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.005 · Cited by 433 · see citing works
Burrowing and nest building behavior as indicators of well-being in mice
Jirkof, P. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.02.001 · Cited by 443 · see citing works
Xu, J. Y., Lian, F., Zhao, L., Zhao, Y., Chen, X., Zhang, X., Guo, Y., Zhang, C., Zhou, Q., Xue, Z., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.177 · Cited by 423 · see citing works
The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Gut microbiota in autism and mood disorders
Mangiola, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.361 · Cited by 413 · see citing works
Gut microbiome and depression: what we know and what we need to know
Winter, G., Hart, R. A., Charlesworth, R. P. G., & Sharpley, C. F. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0072 · Cited by 394 · see citing works
Galley, J. D., Nelson, M. C., Yu, Z., Dowd, S. E., Walter, J., Kumar, P., Lyte, M., & Bailey, M. T. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-189 · Cited by 398 · see citing works
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
Laukens, D., Brinkman, B. M. N., Raes, J., Vos, M. D., & Vandenabeele, P. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv036 · Cited by 378 · see citing works
Kang, S. S., Jeraldo, P., Kurti, A., Miller, M. E. B., Cook, M. D., Whitlock, K. G., Goldenfeld, N. D., Woods, J. A., White, B. A., Chia, N., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-36 · Cited by 322 · see citing works
Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
Huang, Y., Shi, X., Li, Z., Shen, Y., Shi, X., Wang, L., Li, G., Yuan, Y., Wang, J., Zhang, Y., et al. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s188340 · Cited by 311 · see citing works
Modulation of Gut Microbiota–Brain Axis by Probiotics, Prebiotics, and Diet
Liu, X., Cao, S., & Zhang, X. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02404 · Cited by 304 · see citing works
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
Structural & functional consequences of chronic psychosocial stress on the microbiome & host
Bharwani, A., Mian, M. F., Foster, J. A., Surette, M. G., Bienenstock, J., & Forsythe, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.001 · Cited by 293 · see citing works
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294 · see citing works
Tarr, A. J., Galley, J. D., Fisher, S. E., Chichlowski, M., Berg, B. M., & Bailey, M. T. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.025 · Cited by 284 · see citing works
Zhang, J., Song, L., Wang, Y., Liu, C., Zhang, L., Zhu, S., Liu, S., & Duan, L. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14536 · Cited by 292 · see citing works
Current Understanding of Gut Microbiota in Mood Disorders: An Update of Human Studies
Huang, T., Lai, J., Du, Y., Xu, Y., Ruan, L., & Hu, S. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00098 · Cited by 264 · see citing works
Krych, Ł., Hansen, C. H. F., Hansen, A. K., van den Berg, F. W. J., & Nielsen, D. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062578 · Cited by 250 · see citing works
Self-citationGut microbiome composition and diversity are related to human personality traits
Johnson, K. V. ‐. (2019) · Human Microbiome Journal · doi:10.1016/j.humic.2019.100069 · Cited by 241 · see citing works
Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017) · BMC Medicine · doi:10.1186/s12916-016-0771-7 · Cited by 236 · see citing works
Vindigni, S. M., Zisman, T. L., Suskind, D. L., & Damman, C. J. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16644242 · Cited by 228 · see citing works
The role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229 · see citing works
Chen, Y.-H., Bai, J., Wu, D., Yu, S.-F., Qiang, X.-L., Bai, H., Wang, H., & Peng, Z. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.014 · Cited by 225 · see citing works
Nutrition and mental health: A review of current knowledge about the impact of diet on mental health
Grajek, M. K., Krupa-Kotara, K. H., Białek-Dratwa, A., Sobczyk, K., Grot, M., Kowalski, O., & Staśkiewicz‐Bartecka, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.943998 · Cited by 239 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
A Review of Pain Assessment Methods in Laboratory Rodents
Turner, P. V., Pang, D., & Lofgren, J. L. S. (2019) · Comparative Medicine · doi:10.30802/aalas-cm-19-000042 · Cited by 196 · see citing works
Crosstalk between the microbiota-gut-brain axis and depression
Du, Y., Gao, X.-R., Peng, L., & Ge, J.-F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04097 · Cited by 191 · see citing works
Chen, Z., Li, J., Gui, S., Zhou, C., Chen, J., Yang, C., Hu, Z., Wang, H., Zhong, X., Zeng, L., et al. (2018) · Neuroreport · doi:10.1097/wnr.0000000000000985 · Cited by 180 · see citing works
Gut microbiome composition is associated with temperament during early childhood
Christian, L. M., Galley, J. D., Hade, E. M., Schoppe-Sullivan, S., Kamp Dush, C., & Bailey, M. T. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.10.018 · Cited by 191 · see citing works
Stress and the gut microbiota-brain axis
Molina‐Torres, G., Rodríguez-Arrastia, M. J., Román, P., Sánchez‐Labraca, N., & Cardona, D. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000478 · Cited by 186 · see citing works
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works
Zeng, X., Li, X., Li, X., Wei, C., Shi, C., Hu, K., Kong, D., Luo, Q., Xu, Y., Shan, W., et al. (2023) · Blood · doi:10.1182/blood.2022017514 · Cited by 157 · see citing works
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Forsythe, P., Kunze, W., & Bienenstock, J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0604-8 · Cited by 155 · see citing works
Mechanistic Insights into the Link between Gut Dysbiosis and Major Depression: An Extensive Review
Sonali, S., Ray, B., Hediyal, T. A., Rathipriya, A. G., Sunanda, T., Mahalakshmi, A. M., Rungratanawanich, W., Essa, M. M., Qoronfleh, M. W., Chidambaram, S. B., et al. (2022) · Cells · doi:10.3390/cells11081362 · Cited by 159 · see citing works
A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice
Jørgensen, B. P., Hansen, J. T., Krych, Ł., Larsen, C. S., Klein, A. B., Nielsen, D. S., Josefsen, K. E., Hansen, A. K., & Sørensen, D. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103398 · Cited by 150 · see citing works
Self-citationJašarević, E., Rodgers, A. B., & Bale, T. L. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.005 · Cited by 147 · see citing works
Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression
Trzeciak, P., & Herbet, M. (2021) · Nutrients · doi:10.3390/nu13030927 · Cited by 139 · see citing works
Bushyhead, D. W., & Quigley, E. M. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.04.002 · Cited by 135 · see citing works
Psychobiotics and the gut–brain axis: in the pursuit of happiness
Foster, J. A., & Zhou, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s61997 · Cited by 137 · see citing works
The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
Bear, T., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040723 · Cited by 132 · see citing works
The murine lung microbiome in relation to the intestinal and vaginal bacterial communities
Barfod, K. K., Roggenbuck, M., Hansen, L. H., Schjørring, S., Larsen, S. E., Sørensen, S. J., & Krogfelt, K. A. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-303 · Cited by 126 · see citing works
Self-citationHeat-killed lactobacilli alter both microbiota composition and behaviour
Warda, A. K., Rea, K., Fitzgerald, P., Hueston, C. M., González-Tortuero, E., Dinan, T. G., & Hill, C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.047 · Cited by 123 · see citing works
Jiang, P., Green, S. J., Chlipala, G. E., Turek, F. W., & Vitaterna, M. H. (2019) · Microbiome · doi:10.1186/s40168-019-0724-4 · Cited by 122 · see citing works
Can we ‘seize’ the gut microbiota to treat epilepsy?
De Caro, C., Iannone, L. F., Citraro, R., Striano, P., De Sarro, G., Constanti, A., Cryan, J. F., & Russo, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.002 · Cited by 110 · see citing works
Knuesel, T., & Mohajeri, M. (2021) · Nutrients · doi:10.3390/nu14010037 · Cited by 109 · see citing works
The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder
Młynarska, E., Gadzinowska, J., Tokarek, J., Forycka, J., Szuman, A., Franczyk, B., & Rysz, J. (2022) · Nutrients · doi:10.3390/nu14091921 · Cited by 109 · see citing works
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
Winther, G., Jørgensen, B. M., Elfving, B., Nielsen, D. S., Kihl, P., Lund, S. A., Sørensen, D. B., & Wegener, G. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.7 · Cited by 105 · see citing works
Self-citationLindenberg, F., Krych, Ł., Fielden, J., Kot, W., Frøkiær, H., van Galen, G., Nielsen, D. S., & Hansen, A. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-49081-5 · Cited by 102 · see citing works
Self-citationEberl, C., Ring, D., Münch, P. C., Beutler, M., Basic, M., Slack, E. M. C., Schwarzer, M., Šrůtková, D., Lange, A., Frick, J.-S., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02999 · Cited by 98 · see citing works
A Microbial Signature of Psychological Distress in Irritable Bowel Syndrome
Peter, J., Fournier, C., Durdević, M., Knoblich, L., Keip, B., Dejaco, C., Trauner, M. A., & Moser, G. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000630 · Cited by 98 · see citing works
Bäuerl, C., Collado, M. C., Zúñiga, M., Blas, E., & Pérez‐Martínez, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105707 · Cited by 98 · see citing works
The role of magnesium in different inflammatory diseases
Shahi, A., Aslani, S., Ataollahi, M. R., & Mahmoudi, M. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00603-7 · Cited by 98 · see citing works
Li, F., Wang, P., Chen, Z., Sui, X., Xie, X., & Zhang, J. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134297 · Cited by 97 · see citing works
Gao, F., Guo, R., Ma, Q., Li, Y., Wang, W., Fan, Y., Ju, Y., Zhao, B., Gao, Y., Li, Q., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.02.024 · Cited by 90 · see citing works
Man and the Microbiome: A New Theory of Everything?
Butler, M., Cryan, J. F., & Dinan, T. G. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095432 · Cited by 91 · see citing works
The microbiome as a novel paradigm in studying stress and mental health.
Liu, R. T. (2017) · American Psychologist · doi:10.1037/amp0000058 · Cited by 89 · see citing works
Gut microbiota regulates key modulators of social behavior
Parashar, A., & Udayabanu, M. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.002 · Cited by 88 · see citing works
Mouse Vendor Influence on the Bacterial and Viral Gut Composition Exceeds the Effect of Diet
Rasmussen, T. S., de Vries, L., Kot, W., Hansen, L. H., Castro-Mejía, J. L., Vogensen, F. K., Hansen, A. K., & Nielsen, D. S. (2019) · Viruses · doi:10.3390/v11050435 · Cited by 85 · see citing works
Self-citationCao, C., Liu, M., Qu, S., Huang, R., Qi, M.-Z., Zhu, Z., Zheng, J., Chen, Z., Wang, Z., Han, Z., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113055 · Cited by 85 · see citing works
Kreisinger, J., Čížková, D., Schmiedová, L., & Albrecht, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137401 · Cited by 82 · see citing works
Impact of the gut microbiota on rodent models of human disease
Hansen, A. K., Hansen, C. H. F., Krych, Ł., & Nielsen, D. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17727 · Cited by 83 · see citing works
Self-citationSauer, A. K., & Grabrucker, A. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01295 · Cited by 85 · see citing works
Altered Fecal Microbiota Composition in Older Adults With Frailty
Xu, Y., Wang, Y., Li, H., Dai, Y., Chen, D., Wang, M., Jiang, X., Huang, Z., Yu, H., Huang, J., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696186 · Cited by 81 · see citing works
Parker, K. D., Albeke, S. E., Gigley, J. P., Goldstein, A. M., & Ward, N. L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01598 · Cited by 81 · see citing works
Probiotics as an Adjuvant Therapy in Major Depressive Disorder
Vlaini, J. V., Šuran, J., Vlaini, T., & Vukorep, A. L. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160526120928 · Cited by 80 · see citing works
Mortaş, H., Bilici, S., & Karakan, T. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1778717 · Cited by 78 · see citing works
Malan‐Müller, S., Valles‐Colomer, M., Foxx, C. L., Vieira‐Silva, S., van den Heuvel, L. L., Raes, J., Seedat, S., Lowry, C. A., & Hemmings, S. M. J. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.11.009 · Cited by 81 · see citing works
The microbiota, the gut and the brain in eating and alcohol use disorders: A ‘Ménage à Trois’?
Temko, J. E., Bouhlal, S., Farokhnia, M., Lee, M. R., Cryan, J. F., & Leggio, L. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx024 · Cited by 76 · see citing works
The gut microbiota in neuropsychiatric disorders
Grochowska, M., Wojnar, M., & Radkowski, M. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-008 · Cited by 73 · see citing works
Agranyoni, O., Meninger-Mordechay, S., Uzan-Yulzari, A., Oren, Z., Salmon‐Divon, M., Rodin, D., Raz, O., Koman, I. E., Koren, O., Pinhasov, A., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00193-9 · Cited by 73 · see citing works
“WHAT'S BUGGING THE GUT IN OCD?” A REVIEW OF THE GUT MICROBIOME IN OBSESSIVE-COMPULSIVE DISORDER
Turna, J., Kaplan, K. G., Anglin, R., & Ameringen, M. V. (2015) · Depression and Anxiety · doi:10.1002/da.22454 · Cited by 74 · see citing works
Gao, K., Farzi, A., Ke, X., Yu, Y., Chen, C., Chen, S., Yu, T., Wang, H., & Li, Y. (2021) · Food & Function · doi:10.1039/d1fo03723d · Cited by 72 · see citing works
Slyepchenko, A., Carvalho, A. F., Cha, D. S., Kasper, S. F., & McIntyre, R. S. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130205242 · Cited by 71 · see citing works
Cui, C., Li, Y., Gao, H., Zhang, H., Han, J., Zhang, D., Li, Y., Zhou, J., Lu, C., & Su, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186216 · Cited by 69 · see citing works
Beyond phylotyping: understanding the impact of gut microbiota on host biology
Reigstad, C. S., & Kashyap, P. C. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12134 · Cited by 66 · see citing works
Wang, M., Wang, B., Wang, S., Han, L., Wu, H., Ding, M., Ying, L., Mao, Y., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.616219 · Cited by 65 · see citing works
Specificity and stability of the A cromyrmex– P seudonocardia symbiosis
Andersen, S. B., Hansen, L. H., Sapountzis, P., Sørensen, S. J., & Boomsma, J. J. (2013) · Molecular Ecology · doi:10.1111/mec.12380 · Cited by 65 · see citing works
Self-citationPyndt Jørgensen, B., Krych, L., Pedersen, T. B., Plath, N., Redrobe, J. P., Hansen, A. K., Nielsen, D. S., Pedersen, C. S., Larsen, C., & Sørensen, D. B. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.12.042 · Cited by 62 · see citing works
Self-citationThe Murine Lung Microbiome Changes During Lung Inflammation and Intranasal Vancomycin Treatment
Barfod, K. K., Vrankx, K., Mirsepasi‐Lauridsen, H. C., Hansen, J. S., Hougaard, K. S., Larsen, S. T., Ouwenhand, A. C., & Krogfelt, K. A. (2015) · The Open Microbiology Journal · doi:10.2174/1874285801509010167 · Cited by 64 · see citing works
Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats
Rebolledo-Solleiro, D., Roldán-Roldán, G., Díaz, D., Velasco, M., Larqué, C., Rico-Rosillo, G., Vega-Robledo, G. B., Zambrano, E., Hiriart, M., & Pérez de la Mora, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176554 · Cited by 64 · see citing works
The role of the commensal microbiota in adaptive and maladaptive stressor-induced immunomodulation
Mackos, A. R., Maltz, R. M., & Bailey, M. T. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.006 · Cited by 63 · see citing works
Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats
Peterson, V. L., Richards, J. B., Meyer, P., Cabrera‐Rubio, R., Tripi, J. A., King, C. P., Polesskaya, O., Baud, A., Chitre, A. S., Bastiaanssen, T. F. S., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102769 · Cited by 59 · see citing works
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62 · see citing works
Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice
Wang, G., Liu, Q., Guo, L., Zeng, H., Ding, C., Zhang, W., Xu, D., Wang, X., Qiu, J., Dong, Q., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01874 · Cited by 62 · see citing works
Altered fecal microbiota composition in the Flinders sensitive line rat model of depression
Tillmann, S., Abildgaard, A. M., Winther, G., & Wegener, G. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5094-2 · Cited by 61 · see citing works
Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice
Jørgensen, B. P., Winther, G., Kihl, P., Nielsen, D. S., Wegener, G., Hansen, A. K., & Sørensen, D. B. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.10 · Cited by 60 · see citing works
Self-citationOdamaki, T., Kato, K., Sugahara, H., Xiao, J., Abe, F., & Benno, Y. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0173 · Cited by 59 · see citing works
Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract
Sharkey, K. A., & Savidge, T. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.12.006 · Cited by 59 · see citing works
Cheng, L., Chou, P.-Y., Hou, A.-T., Huang, C.-L., Shiu, W.-L., & Wang, S. (2022) · Food & Function · doi:10.1039/d2fo00165a · Cited by 57 · see citing works
Association between gut microbiota and psychiatric disorders: a systematic review
Valle, C. G.-D., Fernández, J., Solá, E., Montoya‐Castilla, I., Morillas, C., & Bañuls, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1215674 · Cited by 61 · see citing works
Rawat, K., Singh, N., Kumari, P., & Saha, L. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0078 · Cited by 58 · see citing works
Wang, Z., xu, X., liu, S., Xiao, Y., Yang, M., zhao, X., Jin, C., Hu, F., Yang, S., Tang, B., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.719829 · Cited by 55 · see citing works
- Authors
- Bangsgaard Bendtsen, K. M., Krych, L., Sørensen, D. B., Pang, W., Nielsen, D. S., Josefsen, K., Hansen, L. H., Sørensen, S. J., & Hansen, A. K.
- Affiliations
- University of Copenhagen (DK)
- Rigshospitalet (DK)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-10-02
- Volume
- 7
- Issue
- 10
- Pages
- e46231
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3462757
- OpenAlex
- W2041032345
- Cited by
- 299
- References
- 69
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 35 · 2021: 25 · 2020: 32 · 2019: 30 · 2018: 16 · 2017: 17 · 2016: 17 · 2015: 23 · 2014: 18 · 2013: 10
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Villum Fonden
- Copenhagen Graduate School for Nanoscience and Nanotechnology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- gut microbiota, housing stress, anxiety-like behavior, cecal microbiota, cytokines, blood glucose, HbA1c, elevated plus maze, light-dark box, open field, tail suspension test, burrowing behavior, Odoribacter, Alistipes, Coriobacteriaceae, Firmicutes, Ruminococcaceae, Lachnospiraceae, BALB/c mice
- MeSH terms
- Animals, Behavior, Animal, Blood Glucose, Female, Hemoglobins, Intestines, Mice, Inbred BALB C, RNA, Ribosomal, 16S, Stress, Physiological, Cytokines, Maze Learning, Mice, Metagenome
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