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Cited by 162Dementia and Cognitive Impairment ResearchSleep and Wakefulness ResearchSleep and related disorders

Parietal Fast Sleep Spindle Density Decrease in Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

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Gorgoni, Maurizio, Lauri, Giulia, Truglia, Ilaria, Cordone, Susanna, Sarasso, Simone, Scarpelli, Serena, Mangiaruga, Anastasia, D’Atri, Aurora +5 more·2016·Neural Plasticity
DOI 10.1155/2016/8376108PMC PMC4811201
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Abstract

Several studies have identified two types of sleep spindles: fast (13–15 Hz) centroparietal and slow (11–13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). Only few studies have separately assessed fast and slow spindles in these patients showing a reduction of fast spindle count, but the possible local specificity of this phenomenon and its relation to cognitive decline severity are not clear. Moreover, fast and slow spindle density have never been assessed in AD/MCI. We have assessed fast and slow spindles in 15 AD patients, 15 amnesic MCI patients, and 15 healthy elderly controls (HC). Participants underwent baseline polysomnographic recording (19 cortical derivations). Spindles during nonrapid eye movements sleep were automatically detected, and spindle densities of the three groups were compared in the derivations where fast and slow spindles exhibited their maximum expression (parietal and frontal, resp.). AD and MCI patients showed a significant parietal fast spindle density decrease, positively correlated with Minimental State Examination scores. Our results suggest that AD-related changes in spindle density are specific for frequency and location, are related to cognitive decline severity, and may have an early onset in the pathology development.

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  • These graphoelements have been addressed as markers for early cognitive deterioration conditions, such as Alzheimer's disease, where memory deterioration is one of the main complaints.

    “These graphoelements have been addressed as markers for early cognitive deterioration conditions, such as Alzheimer’s disease,127–129 where memory deterioration is one of the main complaints.”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [129]

  • Age-related microstructural changes of sleep have been linked to cognitive deterioration.

    “age-related microstructural changes of sleep have been linked to cognitive deterioration.123,127–129”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [129]

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Authors
Gorgoni, M., Lauri, G., Truglia, I., Cordone, S., Sarasso, S., Scarpelli, S., Mangiaruga, A., D’Atri, A., Tempesta, D., Ferrara, M., Marra, C., Rossini, P. M., & De Gennaro, L.
Affiliations
  • Sapienza University of Rome (IT)
  • University of Milan (IT)
  • University of L'Aquila (IT)
  • Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 Coppito, Italy
  • Università Cattolica del Sacro Cuore (IT)
  • Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
ORCID
Venue
Neural Plasticity
Publisher
Wiley
Published
2016
Volume
2016
Pages
1-10
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2016/8376108
PMC
PMC4811201
OpenAlex
W2297783832
Cited by
162
References
15
Citations by year
2026: 13 · 2025: 16 · 2024: 12 · 2023: 19 · 2022: 26 · 2021: 19 · 2020: 21 · 2019: 18 · 2018: 5 · 2017: 11 · 2016: 1
FWCI
10.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
ConnAge PRIN (2010SH7H3F 005)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
sleep spindles, Alzheimer's disease, amnestic mild cognitive impairment, NREM sleep, spindle density, cognitive decline
MeSH terms
Aged, Alzheimer Disease, Amnesia, Attention, Brain, Cognition, Electroencephalography, Female, Humans, Male, Neuropsychological Tests, Sleep, Brain Waves, Cognitive Dysfunction

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