Sleep-Dependent Memory Consolidation in Healthy Aging and Mild Cognitive Impairment
Abstract
Sleep quality and architecture as well as sleep's homeostatic and circadian controls change with healthy aging. Changes include reductions in slow-wave sleep's (SWS) percent and spectral power in the sleep electroencephalogram (EEG), number and amplitude of sleep spindles, rapid eye movement (REM) density and the amplitude of circadian rhythms, as well as a phase advance (moved earlier in time) of the brain's circadian clock. With mild cognitive impairment (MCI) there are further reductions of sleep quality, SWS, spindles, and percent REM, all of which further diminish, along with a profound disruption of circadian rhythmicity, with the conversion to Alzheimer's disease (AD). Sleep disorders may represent risk factors for dementias (e.g., REM Behavior Disorder presages Parkinson's disease) and sleep disorders are themselves extremely prevalent in neurodegenerative diseases. Working memory , formation of new episodic memories, and processing speed all decline with healthy aging whereas semantic, recognition, and emotional declarative memory are spared. In MCI, episodic and working memory further decline along with declines in semantic memory. In young adults, sleep-dependent memory consolidation (SDC) is widely observed for both declarative and procedural memory tasks. However, with healthy aging, although SDC for declarative memory is preserved, certain procedural tasks, such as motor-sequence learning, do not show SDC. In younger adults, fragmentation of sleep can reduce SDC…
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Sleep in elderly people is characterized by lower total sleep time, sleep efficiency, and SWS; a raise in intrasleep awakenings; and higher stages 1 and 2 of sleep and naps compared to younger groups.
“Specifically, sleep in elderly people is characterized by lower total sleep time, sleep efficiency, and SWS; a raise in intrasleep awakenings; and higher stages 1 and 2 of sleep and naps compared to younger groups.122”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [122]
Some researchers observed a reduction in REM sleep percentage in elderly.
“For what concerns REM sleep, some researchers observed a reduction in REM sleep percentage.122”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [122]
Sleep in elderly shows an alteration in its architecture, circadian, and homeostatic features.
“Sleep in elderly shows an alteration in its architecture, circadian, and homeostatic features.122”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [122]
Elderly people wake up more often from stage 2 than from REM sleep.
“Moreover, elderly people wake up more often from stage 2 than from REM sleep.122”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [122]
Cites
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · cited 1× · see citing works
“…a condition of elevated risk, relative to the healthy aged population, for progression to a dementing disorder (Ganguli et al. 2011) including Parkinson’s Disease (Goldman and Litvan 2011; Litvan et al. 2012; Rektorova 2011), and Alzheimer’s disease (AD) (Albert et al. 2011; Venneri et al. 2011).”
BackgroundSleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works
Insights into the ageing mind: a view from cognitive neuroscience
Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223 · see citing works
Hemispheric asymmetry reduction in older adults: the HAROLD model
Cabeza, R. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.1.85 · Cited by 2,125 · see citing works
Sleep-dependent memory consolidation
Stickgold, R. (2005) · Nature · doi:10.1038/nature04286 · Cited by 1,857 · see citing works
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705 · see citing works
Selective review of cognitive aging
SALTHOUSE, T. A. (2010) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617710000706 · Cited by 1,166 · see citing works
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137 · see citing works
Effects of early and late nocturnal sleep on declarative and procedural memory
Plihal, W., & Born, J. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.4.534 · Cited by 1,026 · see citing works
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937 · see citing works
Self-citationSleep forms memory for finger skills
Fischer, S., Hallschmid, M., Elsner, A. L., & Born, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182178199 · Cited by 589 · see citing works
The whats and whens of sleep-dependent memory consolidation
Diekelmann, S., Wilhelm, I., & Born, J. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.08.002 · Cited by 566 · cited 5× · see citing works
“In young adults, declarative memory consolidation has largely been associated with time spent in SWS (Diekelmann and Born 2010; Diekelmann et al. 2009) while procedural memory consolidation is associated with time in NREM stage 2 (Walker et al. 2002) or REM (Plihal and Born 1997).”
BackgroundInfluentialThe circadian clock and pathology of the ageing brain
Kondratova, A. A., & Kondratov, R. V. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3208 · Cited by 482 · see citing works
Landolt, H.-P., Dijk, D.-J., Achermann, P., & Borbély, A. A. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00770-6 · Cited by 350 · see citing works
Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep
Cajochen, C., Münch, M., Knoblauch, V., Blatter, K., & Wirz‐Justice, A. (2006) · Chronobiology International · doi:10.1080/07420520500545813 · Cited by 285 · see citing works
Sleep and memory in healthy children and adolescents - a critical review
Kopasz, M., Loessl, B., Hornyak, M., Riemann, D., Nissen, C., Piosczyk, H., & Voderholzer, U. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.10.006 · Cited by 277 · see citing works
Rabin, L. A., Paré, N., Saykin, A. J., Brown, M. J., Wishart, H. A., Flashman, L. A., & Santulli, R. B. (2009) · Aging, Neuropsychology, and Cognition · doi:10.1080/13825580902825220 · Cited by 256 · see citing works
From Creation to Consolidation: A Novel Framework for Memory Processing
Robertson, E. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000019 · Cited by 236 · see citing works
Age-related decline of sleep-dependent consolidation
Spencer, R. M. C., Gouw, A. M., & Ivry, R. B. (2007) · Learning & Memory · doi:10.1101/lm.569407 · Cited by 201 · see citing works
Self-citationScullin, M. K. (2013) · Psychology and Aging · doi:10.1037/a0028830 · Cited by 181 · see citing works
Is there a link between sleep changes and memory in Alzheimer's disease?
Rauchs, G., Schabus, M., Parapatics, S., Bertran, F., Clochon, P., Hot, P., Denise, P., Desgranges, B., Eustache, F., Gruber, G., et al. (2008) · NeuroReport · doi:10.1097/wnr.0b013e32830867c4 · Cited by 179 · see citing works
Sleep modulates word-pair learning but not motor sequence learning in healthy older adults
Wilson, J. K., Baran, B., Pace-Schott, E. F., Ivry, R. B., & Spencer, R. M. C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.029 · Cited by 174 · see citing works
Self-citationHedden, T., & Gabrieli, J. D. E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.089 · Cited by 146 · see citing works
Sleep-Dependent Consolidation of Contextual Learning
Spencer, R. M. C., Sunm, M., & Ivry, R. B. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.094 · Cited by 138 · see citing works
Self-citationSleep Optimizes Motor Skill in Older Adults
Tucker, M., McKinley, S., & Stickgold, R. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03324.x · Cited by 70 · see citing works
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Cited by
Sorted by citations
Connections between sleep and cognition in older adults
Yaffe, K., Falvey, C. M., & Hoang, T. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70172-3 · Cited by 796 · see citing works
Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults
Godos, J., Ferri, R., Caraci, F., Cosentino, F. I. I., Castellano, S., Galvano, F., & Grosso, G. (2019) · Nutrients · doi:10.3390/nu11050976 · Cited by 145 · see citing works
Spotlight on dream recall: the ages of dreams
Mangiaruga, A., Scarpelli, S., Bartolacci, C., & De Gennaro, L. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s135762 · Cited by 39 · see citing works
“Specifically, sleep in elderly people is characterized by lower total sleep time, sleep efficiency, and SWS; a raise in intrasleep awakenings; and higher stages 1 and 2 of sleep and naps compared to younger groups.(122) For what concerns REM sleep, some researchers observed a reduction in REM sleep percentage.”
BackgroundResultInfluentialSalfi, F., D’Atri, A., Tempesta, D., De Gennaro, L., & Ferrara, M. (2020) · Brain Sciences · doi:10.3390/brainsci10050300 · Cited by 36 · see citing works
- Authors
- Pace-Schott, E. F., & Spencer, R. M. C.
- Affiliations
- Harvard University (US)
- University of Massachusetts Amherst (US)
- Corresponding author
- Pace-Schott, Edward F.
- Venue
- Current Topics in Behavioral Neurosciences
- Publisher
- Springer Berlin Heidelberg
- Published
- 2014
- Volume
- 25
- Pages
- 307-330
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W1545648730
- Cited by
- 112
- References
- 25
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 16 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 3 · 2015: 7 · 2014: 2
- FWCI
- 16.47
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current topics in behavioral neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R00AG029710)
- National Institute of Mental Health (R21MH090357)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- sleep-dependent memory consolidation, healthy aging, mild cognitive impairment, Alzheimer's disease, sleep architecture, slow-wave sleep, sleep spindles, REM sleep, circadian rhythm, sleep fragmentation, sleep disorders, episodic memory, working memory, procedural memory, neurodegenerative diseases, cognitive decline
- MeSH terms
- Aged, Aging, Humans, Memory, Sleep, Sleep Wake Disorders, Cognitive Dysfunction
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