Brain activation to favorite music in healthy controls and depressed patients
Abstract
Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals provided favorite music and identified neutral music from selections provided. In the fMRI scanner, individuals heard their neutral and their favorite music for 3 min each. Favorite versus neutral music-listening contrasts showed greater activation in controls than depressed patients in medial orbital frontal cortex and nucleus accumbens/ventral striatum. Left medial prefrontal cortex activity was positively correlated with pleasure scores, whereas middle temporal cortex and globus pallidus were negatively correlated with pleasure. This paradigm activated neurocircuitry of reward processing and showed clinically meaningful alterations in depression.
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Reduced mesolimbic activity in MDD is found during reward anticipation and outcomes in both adults and children, and during reward learning.
“Reduced mesolimbic activity in MDD has been found during reward anticipation and outcomes in both adults and children [210,219-227] and during reward learning [206].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [223]
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Greening, S. G. (2013) · Scholarship@Western (Western University)
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- Authors
- Osuch, E. A., Bluhm, R. L., Williamson, P. C., Théberge, J., Densmore, M., & Neufeld, R. W. J.
- Affiliations
- Western University (CA)
- Old Dominion University (US)
- Lawson Health Research Institute (CA)
- Corresponding author
- Osuch, Elizabeth A.
- Venue
- NeuroReport
- Published
- 2009-08-26
- Volume
- 20
- Issue
- 13
- Pages
- 1204-1208
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1973576997
- Cited by
- 99
- References
- 24
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schulich School of Medicine and Dentistry, Western University
- Schulich School of Medicine and Dentistry
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- music listening, depression, reward processing, medial orbitofrontal cortex, nucleus accumbens, ventral striatum, medial prefrontal cortex, pleasure, middle temporal cortex, globus pallidus, brain activation
- MeSH terms
- Adolescent, Adult, Attitude, Auditory Perception, Brain, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Music, Psychological Tests, Reward, Young Adult
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