Cited by 100Neuroscience and Music PerceptionNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Brain activation to favorite music in healthy controls and depressed patients

Osuch, Elizabeth A., Bluhm, Robyn L., Williamson, Peter C., Théberge, Jean, Densmore, Maria, Neufeld, Richard W.J.·2009·NeuroReport

Abstract

Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals provided favorite music and identified neutral music from selections provided. In the fMRI scanner, individuals heard their neutral and their favorite music for 3 min each. Favorite versus neutral music-listening contrasts showed greater activation in controls than depressed patients in medial orbital frontal cortex and nucleus accumbens/ventral striatum. Left medial prefrontal cortex activity was positively correlated with pleasure scores, whereas middle temporal cortex and globus pallidus were negatively correlated with pleasure. This paradigm activated neurocircuitry of reward processing and showed clinically meaningful alterations in depression.

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Crossref · 10.1097/wnr.0b013e32832f4da3

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Authors
Osuch, E. A., Bluhm, R. L., Williamson, P. C., Théberge, J., Densmore, M., & Neufeld, R. W. J.
Affiliations
  • Western University (CA)
  • Old Dominion University (US)
  • Lawson Health Research Institute (CA)
Corresponding author
Osuch, Elizabeth A.
Venue
NeuroReport
Published
2009-08-26
Volume
20
Issue
13
Pages
1204-1208
ISSN
0959-4965 (ISSN-L)
OpenAlex
W1973576997
Cited by
99
References
24
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 8
FWCI
3.56
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Schulich School of Medicine and Dentistry, Western University
  • Schulich School of Medicine and Dentistry
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
music listening, depression, reward processing, medial orbitofrontal cortex, nucleus accumbens, ventral striatum, medial prefrontal cortex, pleasure, middle temporal cortex, globus pallidus, brain activation
MeSH terms
Adolescent, Adult, Attitude, Auditory Perception, Brain, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Music, Psychological Tests, Reward, Young Adult

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