Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects
Abstract
Anhedonia, the reduced capacity to gain pleasure from pleasurable experiences, is a key symptom of major depression and schizophrenia. Reduced hedonic capacity can also be measured as an enduring trait in non-clinical subjects. Such altered hedonic capacity is likely the result of a basic neuropsychophysiological dysfunction and a vulnerability marker that potentially precedes and contributes to the liability of developing psychiatric disorders. The characterization of the structural and functional neural correlates of trait anhedonia in non-clinical individuals may provide new insights for the early detection of such psychiatric diseases. Twenty-nine non-clinical subjects were scanned at the Montreal Neurological Institute. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale. Semi-automated and automated structural MRI segmentation techniques were used to explore structural correlates of trait anhedonia. Seventeen of the 29 subjects also underwent a functional imaging task where responses to the viewing of affective stimuli were examined to identify the functional correlates of trait anhedonia. Trait anhedonia was inversely related to anterior caudate volume, but positively related to ventromedial prefrontal cortex activity during the processing of positive information. These findings may reflect a specific kind of vulnerability for the development of psychiatric affective disorders and suggest that trait anhedonia may be linked to a volumetric re…
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Depressed individuals or those with trait-like anhedonia display attenuated NAc reactivity to pleasurable stimuli, monetary rewards, and positive words.
“Additionally, depressed individuals or those with trait-like anhedonia display attenuated reactivity of the NAc to pleasurable stimuli (Harvey et al., 2007; Keedwell et al., 2005), monetary rewards (Pizzagalli et al., 2009; Wacker et al., 2009), and positive words (Epstein et al., 2006).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Harvey et al., 2007
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- Authors
- Harvey, P.-O., Pruessner, J., Czechowska, Y., & Lepage, M.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Lepage, M
- Venue
- Molecular Psychiatry
- Published
- 2007-05-15
- Volume
- 12
- Issue
- 8
- Pages
- 767-775
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1983961948
- Cited by
- 259
- References
- 69
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 13 · 2020: 54 · 2019: 12 · 2018: 12 · 2017: 7 · 2016: 13 · 2015: 19 · 2014: 16 · 2013: 10 · 2012: 10
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- hedonic capacity, individual differences, ventromedial prefrontal cortex, functional MRI, vulnerability indicators, major depressive disorder, schizophrenia, basal ganglia
- MeSH terms
- Adult, Affect, Brain Mapping, Caudate Nucleus, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Photic Stimulation, Reference Values, Reward, Temperament, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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