The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response
Abstract
PURPOSE OF REVIEW: Major depressive disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Despite its considerable burden, our understanding of its pathophysiology remains rudimentary, and a validated biomarker has yet to be identified. Antidepressants are the most common treatment for MDD, yet roughly one-third of patients experience an inadequate response. Thus, there is a great need for not only identifying biomarkers of MDD but also those that can predict and monitor or just monitor response to treatment. RECENT FINDINGS: MicroRNAs (miRNAs) act as endogenous fine-tuners and on-off switches of gene expression. Several lines of evidence now suggest that miRNAs are involved in the pathogenesis of neuropsychiatric disorders. As such, miRNAs offer great hope as biomarkers of disease and response to treatment. SUMMARY: In this review, we discuss the growing field, investigating peripheral miRNAs as potential biomarkers of major depression and treatment response. A noninvasive and validated biomarker of MDD or treatment response will help clinicians guide treatment selection. Ultimately, these findings provide important steps in the development of early diagnostic tools, preventive strategies, and effective pharmacological treatment for psychiatric disorders.
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“This highlights miRNAs’ potential as biomarkers for treatment response; however, further studies are needed.”
From Epigenetics and depression (2019) · cites this paper as [31]
In the citing paper
“Other studies of postmortem brain and peripheral tissues have identified altered levels of miRNAs in patients with MDD and after treatment with antidepressant medication (see ref 31 for a review).”
From Epigenetics and depression (2019) · cites this paper as [31]
Citations
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“In addition, several lines of evidence suggest that that MDD is a systemic illness(64, 65), so even if peripheral samples would not be good surrogates of the CNS, there is still value to study peripheral samples per se because we could detect peripheral processes that may be etiologically relevant…”
BackgroundInflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
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MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
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Lima, C. N. D. C., Pink, O., & Fries, G. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00018-1
Youness, E. R., Zaki, M. E., El-Bassyouni, H. T., Hussein, M. A. E. A., Tawfeek, H. M., Girgiss, M. W., & Ashour, M. N. (2021) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2021.83757.4108
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Progress in Biomarkers to Improve Treatment Outcomes in Major Depressive Disorder
Vaccarino, S. R., Ceniti, A. K., Rotzinger, S., & Kennedy, S. H. (2024) · Cambridge University Press eBooks · doi:10.1017/9781108973922.024
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Kaadt, E., Søkilde, R., Hansen, H. D., Raval, N. R., Donovan, L. L., Just, J., Knudsen, G. M., & Elfving, B. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179222
Metadata
- Authors
- Lopez, J. P., Kos, A., & Turecki, G.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Turecki, Gustavo
- Venue
- Current Opinion in Psychiatry
- Published
- 2018-01
- Volume
- 31
- Issue
- 1
- Pages
- 7-16
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2766080306
- Cited by
- 108
- References
- 67
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 15 · 2020: 20 · 2019: 14 · 2018: 6
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@McGill (McGill) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, microRNA, biomarkers, antidepressant response, peripheral biomarkers, depression pathophysiology, treatment response prediction, early detection of depression
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Humans, Biomarkers, Treatment Outcome, MicroRNAs
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