Cited by 109Treatment of Major DepressionMicroRNA in disease regulationTryptophan and brain disorders

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Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response

Lopez, Juan Pablo, Kos, Aron, Turecki, Gustavo·2018·Current Opinion in Psychiatry

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Abstract

PURPOSE OF REVIEW: Major depressive disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Despite its considerable burden, our understanding of its pathophysiology remains rudimentary, and a validated biomarker has yet to be identified. Antidepressants are the most common treatment for MDD, yet roughly one-third of patients experience an inadequate response. Thus, there is a great need for not only identifying biomarkers of MDD but also those that can predict and monitor or just monitor response to treatment. RECENT FINDINGS: MicroRNAs (miRNAs) act as endogenous fine-tuners and on-off switches of gene expression. Several lines of evidence now suggest that miRNAs are involved in the pathogenesis of neuropsychiatric disorders. As such, miRNAs offer great hope as biomarkers of disease and response to treatment. SUMMARY: In this review, we discuss the growing field, investigating peripheral miRNAs as potential biomarkers of major depression and treatment response. A noninvasive and validated biomarker of MDD or treatment response will help clinicians guide treatment selection. Ultimately, these findings provide important steps in the development of early diagnostic tools, preventive strategies, and effective pharmacological treatment for psychiatric disorders.

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Authors: Lopez, J. P., Kos, A., & Turecki, G.
Affiliations: Max Planck Institute of Psychiatry (DE)
Douglas Mental Health University Institute (CA)
Corresponding author: Turecki, Gustavo
ORCID: Kos, Aron
Turecki, Gustavo
Venue: Current Opinion in Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-01
Volume: 31
Issue: 1
Pages: 7-16
ISSN: 0951-7367 (ISSN-L)
DOI: 10.1097/yco.0000000000000379
OpenAlex: W2766080306
Cited by: 108
References: 67
Citations by year: 2026: 5 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 15 · 2020: 20 · 2019: 14 · 2018: 6
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Psychiatry (publishedVersion)
PubMed (publishedVersion)
eScholarship@McGill (McGill) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, microRNA, biomarkers, antidepressant response, peripheral biomarkers, depression pathophysiology, treatment response prediction, early detection of depression
MeSH terms: Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Humans, Biomarkers, Treatment Outcome, MicroRNAs

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Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response

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