Cited by 187Schizophrenia research and treatmentMental Health and PsychiatryMental Health and Patient Involvement

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Recovery from schizophrenia: is it possible?

Vita, Antonio, Barlati, Stefano·2018·Current Opinion in Psychiatry

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Abstract

PURPOSE OF REVIEW: Schizophrenia has a heterogeneous range of end states, from severe cases requiring repeated hospitalization to cases in which a single illness episode is followed by complete remission. The purpose of the present review is to examine recent literature on recovery in schizophrenia, focusing on the predictive factors and on the possibility to achieve it. RECENT FINDINGS: Roughly half of schizophrenia patients recovered or significantly improved over the long term, suggesting that functional remission is possible. Several factors predict the course of schizophrenia, including demographic, clinical, and treatment characteristics, as well as socioeconomic variables. Antipsychotics are a fundamental element of schizophrenia treatment, although the available antipsychotics have significant limitations. In this context, psychosocial interventions are supported by substantial evidence of efficacy in many outcome measures and rehabilitation interventions should be considered as an evidence-based practice and need to become a part of the standard treatment of schizophrenia. SUMMARY: As recovery is a multidimensional concept, some authors suggested that at least two areas should be taken into account: clinical remission and social functioning. Functional outcome should be a priority target for therapeutic interventions in schizophrenia and in this perspective measuring treatment response, remission and functional recovery is essential. Only an integrated and multifaceted approach involving pharmacotherapy, psychosocial interventions, and attention to environmental circumstances can improve outcome in schizophrenia.

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Authors: Vita, A., & Barlati, S.
Affiliations: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
Corresponding author: Vita, Antonio
ORCID: Vita, Antonio
Venue: Current Opinion in Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-05
Volume: 31
Issue: 3
Pages: 246-255
ISSN: 0951-7367 (ISSN-L)
DOI: 10.1097/yco.0000000000000407
OpenAlex: W2789223245
Cited by: 187
References: 87
Citations by year: 2026: 9 · 2025: 17 · 2024: 37 · 2023: 37 · 2022: 32 · 2021: 24 · 2020: 22 · 2019: 7 · 2018: 2
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Psychiatry (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Health Professions › General Health Professions › Mental Health and Patient Involvement
Keywords: schizophrenia, recovery, functional remission, social functioning, clinical remission, predictive factors, antipsychotic drugs, psychosocial interventions, rehabilitation, treatment response, socioeconomic factors
MeSH terms: Psychiatric Rehabilitation, Humans, Prognosis, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Recovery of Function, Evidence-Based Practice

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