Statistical methods to detect pleiotropy in human complex traits

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

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Biological insights from 108 schizophrenia-associated genetic loci

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Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

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Mendelian randomization: genetic anchors for causal inference in epidemiological studies

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Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

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Genetic studies of body mass index yield new insights for obesity biology

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Complement factor H polymorphism in age-related macular degeneration

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Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

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An atlas of genetic correlations across human diseases and traits

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A unified mixed-model method for association mapping that accounts for multiple levels of relatedness

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Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

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Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

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Genome-wide association studies for common diseases and complex traits

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A reference panel of 64,976 haplotypes for genotype imputation

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A new multipoint method for genome-wide association studies by imputation of genotypes

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Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

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Statistical Analysis of Correlated Data Using Generalized Estimating Equations: An Orientation

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Mixed linear model approach adapted for genome-wide association studies

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A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

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Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome

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Power and predictive accuracy of polygenic risk scores

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A Selected Core Microbiome Drives the Early Stages of Three Popular Italian Cheese Manufactures

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Using multiple genetic variants as instrumental variables for modifiable risk factors

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

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Procedures for Comparing Samples with Multiple Endpoints

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Detection and interpretation of shared genetic influences on 42 human traits

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PRSice: Polygenic Risk Score software

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A mega-analysis of genome-wide association studies for major depressive disorder

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A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic

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Pleiotropy in complex traits: challenges and strategies

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Rare-Variant Association Analysis: Study Designs and Statistical Tests

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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

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Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction

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Mendelian randomization as an instrumental variable approach to causal inference

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

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Sparse whole-genome sequencing identifies two loci for major depressive disorder

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Efficient multivariate linear mixed model algorithms for genome-wide association studies

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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

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miR-34 – a microRNA replacement therapy is headed to the clinic

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Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

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The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

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Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

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Pervasive Sharing of Genetic Effects in Autoimmune Disease

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Meta-analysis methods for genome-wide association studies and beyond

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A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians

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Abundant Pleiotropy in Human Complex Diseases and Traits

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Population structure, differential bias and genomic control in a large-scale, case-control association study

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Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

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Approximately independent linkage disequilibrium blocks in human populations

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One Hundred Years of Pleiotropy: A Retrospective

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Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

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Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

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A mixed-model approach for genome-wide association studies of correlated traits in structured populations

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The many faces of pleiotropy

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Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension

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Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

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Genome-wide meta-analysis identifies new susceptibility loci for migraine

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Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

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Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

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DNA sequencing technologies: 2006–2016

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Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

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Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies

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MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

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Genome-wide association analysis identifies susceptibility loci for migraine without aura

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C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

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Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

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Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk

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Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

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Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

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Rare Variant Association Analysis Methods for Complex Traits

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Unravelling the human genome–phenome relationship using phenome-wide association studies

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Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

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Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

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A multivariate test of association

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A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

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A Unified Framework for Association Analysis with Multiple Related Phenotypes

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GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation

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Commentary: The concept of 'Mendelian Randomization'

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TATES: Efficient Multivariate Genotype-Phenotype Analysis for Genome-Wide Association Studies

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Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression

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Friendly rivalry

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A multivariate family-based association test using generalized estimating equations: FBAT-GEE

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A Comparison of Multivariate Genome-Wide Association Methods

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A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait

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Maximizing the Power of Principal-Component Analysis of Correlated Phenotypes in Genome-wide Association Studies

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