Genomic Insights into the Population History and Adaptive Traits of Latin American Criollo Cattle
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Abstract
ABSTRACT Criollo cattle, descendants of animals brought by Iberian colonists to the Americas, have been subject to centuries of natural and human-mediated selection in novel tropical agroecological zones. Consequently, these breeds have evolved distinct characteristics such as resistance to disease and exceptional heat tolerance. In addition to European taurine ( Bos taurus ) ancestry, it has been proposed that gene flow from African taurine and Asian indicine ( Bos indicus ) cattle has shaped the ancestry of Criollo cattle. In this study, we analysed Criollo breeds from Colombia and Venezuela using whole-genome sequencing (WGS) and single-nucleotide polymorphism (SNP) array data to examine population structure and admixture at high resolution. Analysis of genetic structure and ancestry components provided evidence for African taurine and Asian indicine admixture in Criollo cattle. In addition, using WGS data, we detected selection signatures associated with a myriad of adaptive traits, revealing genes linked to thermotolerance, reproduction, fertility, immunity, and distinct coat and skin coloration traits. This study underscores the remarkable adaptability of Criollo cattle and highlights the genetic richness and potential of these breeds in the face of climate change, habitat flux, and disease challenges. Further research is warranted to leverage these findings for more effective and sustainable cattle breeding programmes.
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Brazilian and American breeds such as Creole and Nellore share similar genetic backgrounds with southern European cattle; they carry the T3 and T1 mitochondrial haplogroups and exhibit indicine ancestry.
“Brazilian and American breeds such as Creole and Nellore share similar genetic backgrounds with southern European cattle. They carry the T3 and T1 mitochondrial haplogroups and exhibit indicine ancestry [54,69,70,71,72,73,74,75].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [73]
The Results (Population differentiation, genetic structure and admixture; page not provided) report that Criollo cattle cluster with Iberian taurine cattle and show varying indicine admixture. The Introduction reports a T1-c mitochondrial haplotype in Criollo cattle. The passages do not establish T3 carriage or extend these findings to Nellore cattle; a search for Nellore and T3 found no supporting passage. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe PRLR gene is linked to the short, sleek coat phenotype and was found to be under selection in Latin American Criollo cattle.
“The PRLR gene (prolactin receptor), which is linked to the short, sleek coat phenotype, was found to be under selection in Latin American Criollo cattle [73].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [73]
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Ancient DNA Confirms Diverse Origins of Early Post-Columbian Cattle in the Americas
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Heat stress response in slick vs normal-haired Criollo Limonero heifers in a tropical environment
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Novel insights into Sabino1 and splashed white coat color patterns in horses
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Cattle habitat selection in response to weather extremes within a native Aspen Parkland rangeland
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Genetic Diversity and Population Structure of Two Mexican Creole Cattle Populations
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Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle
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- Authors
- Ward, J. A., Ng'ang'a, S. I., Randhawa, I. A. S., McHugo, G. P., O'Grady, J. F., Flórez, J. M., Browne, J. A., Pérez O’Brien, A. M., Landaeta-Hernández, A. J., Garcia, J. F., Sonstegard, T. S., Frantz, L. A. F., Salter-Townshend, M., & MacHugh, D. E.
- Affiliations
- University College Dublin (IE)
- Palaeogenomics Group, Department of Veterinary Sciences, Ludwig Maximilian University , Munich D-80539, Germany
- The University of Queensland (AU)
- Universidade Estadual Paulista (Unesp) (BR)
- Acceligen , Eagan, MN 55121, USA
- Universidad del Zulia (VE)
- Department of Preventive Veterinary Medicine and Animal Reproduction, School of Agricultural and Veterinarian Sciences, São Paulo State University (Unesp) , Jaboticabal, Brazil
- Queen Mary University of London (GB)
- School of Mathematics and Statistics, University College Dublin , Dublin D04 V1W8, Ireland
- Corresponding author
- MacHugh, David E.
- ORCID
- Venue
- Royal Society Open Science
- Publisher
- The Royal Society
- Published
- 2024-03
- Volume
- 11
- Issue
- 3
- Pages
- 231388-231388
- ISSN
- 2054-5703 (ISSN-L)
- PMC
- PMC10990470
- OpenAlex
- W4393227597
- Cited by
- 17
- References
- 104
- Citations by year
- 2026: 11 · 2025: 5 · 2024: 1
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Royal Society Open Science (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Science Foundation Ireland (18/CRT/6214, SFI/15/IA/3154)
- Department of Agriculture, Food and the Marine, Ireland (17/RD/USROI/52)
- National Institute of Food and Agriculture (TARGET-TB)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- Criollo cattle, demographic history, admixture, selection signatures, adaptive traits, heat tolerance, disease resistance, immune traits, cattle breeding, Colombia, Venezuela
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