Latent equid herpesviruses 1 and 4: detection and distinction using the polymerase chain reaction and co-cultivation from lymphoid tissues.

Welch, H. M.; Bridges, C. G.; Lyon, A. M.; Griffiths, L.; Edington, N.

doi:10.1099/0022-1317-73-2-261

Cited by 204Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesViral-associated cancers and disorders

Latent equid herpesviruses 1 and 4: detection and distinction using the polymerase chain reaction and co-cultivation from lymphoid tissues.

Welch, H. M., Bridges, C. G., Lyon, A. M., Griffiths, L., Edington, N.·1992·Journal of General Virology

DOI 10.1099/0022-1317-73-2-261

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Abstract

The polymerase chain reaction (PCR) and co-cultivation were used to identify the lymphoreticular system as the site of latency of equid herpesvirus I (EHV-1). Primers for PCR were designed from aligned nucleotide sequences of the glycoprotein gB genes to amplify the same region of both the EHV-1 and EHV-4 genomes. Subsequent restriction digests using specific enzymes distinguished the amplified fragments of the EHV-1 genome from those of the EHV-4 genome. Ten weeks following an experimental infection of five ponies with EHV-1, latent virus was detected by PCR and recovered by co-cultivation, predominantly from lymphoid tissues draining the respiratory tract. Significantly, latent EHV-1 also persisted in peripheral blood leukocytes (PBL). Latent EHV-4, presumably from a preceding natural infection, was also detected in some tissues, including PBL, from all animals. Of additional interest was the recovery of EHV-1 and -4 only in the presence of the ubiquitous EHV-2.

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EHV-1 establishes latency in respiratory associated lymphoid tissues such as mandibular, retropharyngeal and bronchial lymph nodes.
“EHV-1 has also been shown to establish latency in respiratory associated lymphoid tissues (e.g., mandibular, retropharyngeal and bronchial lymph nodes).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Welch et al., 1992

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Authors: Welch, H. M., Bridges, C. G., Lyon, A. M., Griffiths, L., & Edington, N.
Affiliations: Royal Veterinary College (GB)
Venue: Journal of General Virology
Publisher: Microbiology Society
Published: 1992-02-01
Volume: 73
Issue: 2
Pages: 261-268
ISSN: 0022-1317 (ISSN-L)
1465-2099
DOI: 10.1099/0022-1317-73-2-261
OpenAlex: W2165142761
Cited by: 203
References: 41
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 6 · 2013: 12 · 2012: 3
FWCI: 9.59
Type: journal article
Language: en
Open access: closed
Locations: Journal of General Virology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: equine herpesvirus 1, viral latency, lymphoid tissue, horses, peripheral blood leukocytes, glycoprotein B gene, restriction fragment length polymorphism, co-culture, viral persistence
MeSH terms: Acute Disease, Animals, Base Sequence, DNA, Viral, Herpesvirus 1, Equid, Fluorescent Antibody Technique, Herpesviridae, Herpesviridae Infections, Horse Diseases, Horses, Leukocytes, Lymphoid Tissue, Molecular Sequence Data, Respiratory System, Polymorphism, Restriction Fragment Length, Restriction Mapping, Polymerase Chain Reaction

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Latent equid herpesviruses 1 and 4: detection and distinction using the polymerase chain reaction and co-cultivation from lymphoid tissues.

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